Results 151 to 160 of about 27,223 (192)

Integrating Tissue Proteomics and Urinary Analyses to Capture Dynamic Podocyte Injury. [PDF]

Kidney Int Rep
Kajana X, Caridi G, Angeletti A.
europepmc   +1 more source

Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions. [PDF]

Immunol Rev
Awad W, Abdelaal MR, Letoga V, McCluskey J, Rossjohn J.   +4 more
europepmc   +1 more source

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MR1 antigen presentation to MAIT cells and other MR1-restricted T cells

Nature Reviews Immunology, 2023
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and location and present them to specialized T cells. MHC class I-related protein 1 (MR1) presents a range of small molecule antigens to MR1-restricted T (MR1T) lymphocytes. The
Hamish E G Mcwilliam, Jose A Villadangos
exaly   +4 more sources

MR1-dependent antigen presentation [PDF]

Seminars in Cell and Developmental Biology, 2018
MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, -B, and -C, little MR1 is on the cell surface.
Elham Karamooz, Melanie J Harriff, David M Lewinsohn   +2 more
exaly   +3 more sources

MR1-restricted pan-cancer T cells [PDF]

Nature Reviews Immunology, 2020
Researchers identify a new population of cytotoxic T cells that recognize the non-polymorphic MHC class I-related molecule MR1 on multiple different cancer cells, raising the prospect of its use as T cell-based therapy for multiple cancers.
exaly   +3 more sources

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage [PDF]

Science Immunology, 2018
A diverse array of microbial metabolites binds to MR1 and selectively activates MR1-restricted T cells.
Melanie J Harriff, Curtis McMurtrey, Cara A Froyd   +2 more
exaly   +3 more sources

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

2023
AbstractMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, has until recently been reported to be monomorphic. Tumor cell-specific MR1 restricted T cell receptors (TCRs) have been described, offering potential therapeutic application for cancer treatment. We show that human T cells expressing a
Terri V Cornforth, Nathifa Moyo, Suzanne Cole, Emily Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M Denham, Gurdyal S Besra, Natacha Veerapen, Patricia T Illing, Julian P Vivian, Jeremy M Raynes, Jérôme Le Nours, Anthony W Purcell, Samit Kundu, Jonathan D Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes   +22 more
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Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands

Journal of Medicinal Chemistry, 2023
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are modulated by ligands presented on MHC class I-related proteins (MR1). These cells have attracted attention as potential drug targets because of their involvement in the initial response to infection and various disorders.
Takuro Matsuoka, Akira Hattori, Shinya Oishi, Mitsugu Araki, Biao Ma, Toshiki Fujii, Norihito Arichi, Yasushi Okuno, Hideaki Kakeya, Sho Yamasaki, Hiroaki Ohno, Shinsuke Inuki   +11 more
openaire   +2 more sources

MR1 discovery

Immunogenetics, 2016
The moment of MR1 discovery is described. The MR1 gene is the first and the last reported human MHC-related gene intentionally isolated from the human genome composed of three billion base pairs. Evolutionary considerations formed the basis of its isolation.
openaire   +2 more sources