Results 171 to 180 of about 8,186 (190)

Production of MR1 Tetramers Loaded with Microbial Ligands

2019
In lieu of peptides, the monomorphic MHC-I-like molecule MR1 presents small molecule antigens to stimulate a subset of αβ T cells known as mucosal-associated (semi-) invariant T (MAIT) cells or, more broadly, MR1-restricted (MR1T) cells. The MR1 ligands identified to date are limited to derivatives and intermediates of the riboflavin and folate ...
Nicole A, Ladd, Cara A, Froyd, Erin J, Adams   +2 more
openaire   +2 more sources

The MR1/MAIT cell axis in CNS diseases

Brain, Behavior, and Immunity
Mucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that can be found throughout the body, predominantly in mucosal sites, the lungs and in the peripheral blood. MAIT cells recognize microbial-derived vitamin B (e.g., riboflavin) metabolite antigens that are presented by the major histocompatibility complex class I ...
Rashmi Shrinivasan, Season K. Wyatt-Johnson, Randy R. Brutkiewicz   +2 more
openaire   +2 more sources

MR1-Restricted Immunity in Hematologic Malignancy

Blood
Introduction: Immunotherapy has revolutionized the treatment of many cancer types, yet approved agents such as immune checkpoint inhibitors have shown inconsistent efficacy against blood cancers. There are inherent limitations to targeting conventional peptide-specific T cells as they produce variable, patient ...
Danielle Xie, Rimanpreet Kaur, Arshia Arasappan, Samantha Tran, Sagar Makavana, Kathrene Rylova, Atul Pradhan, Charles Kyriakos Vorkas, Christina Y. Lee   +8 more
openaire   +1 more source

The MR1-UAV

2023
openaire   +1 more source

Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1

Journal of Biological Chemistry, 2022
Carl J H Wang, Jeffrey Y W Mak, Patricia T Illing   +2 more
exaly  

MR1 encompasses at least six allele groups with coding region alterations

Hla, 2021
Sidonia B G Eckle, Sake Van Wageningen
exaly  

MPEC 2024-N03 : 2024 MR1

The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
openaire   +1 more source

Front and Center (Mr1)

The Physics Teacher, 2005
openaire   +1 more source

Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals

Immunogenetics, 2012
Kentaro Tsukamoto, Janine E Deakin, Jennifer A Marshall Graves   +2 more
exaly  

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Proceedings of the National Academy of Sciences of the United States of America, 2020
Hamish E G Mcwilliam, Jeffrey Y W Mak, Wael Awad   +2 more
exaly