Results 61 to 70 of about 8,186 (190)

Characterisation of MR1-reactive T cells using MR1-Ag tetramers

, 2023
The major histocompatibility complex class I-related protein 1 (MR1) presents small non-peptide antigens to unconventional T cells, most notably mucosal-associated invariant T (MAIT) cells, and MR1-reactive T (MR1T) cells.
Lee, Clarice Zi Qi
core  

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

Frontiers in Immunology, 2020
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1 ...
Michael N. T. Souter, Sidonia B. G. Eckle   +1 more
doaj   +1 more source

Image_2_Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation.tif

, 2023
IntroductionThe antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells ...
Caroline L. Ashley (10882632), James McCluskey (1845217), Rommel A. Mathias (2321233), Allison Abendroth (5155166), Richard J. Stanton (9030887), Ceri A. Fielding (14597126), Hamish E. G. McWilliam (6746912), David P. Fairlie (180958), Jamie Rossjohn (127997), Jose A. Villadangos (6746939), Barry Slobedman (5155160), Brian P. McSharry (9110760)   +11 more
core   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

Artificial neural network modelling of natural gas dehydration process

Discover Chemical Engineering
A multi-input–multi-output artificial neuron network (MIMO-ANN) model has been developed for process monitoring and improvement on a natural gas glycol dehydration process.
Brandon Z. H. Goh, Rafil Elyas, Anuar Hamid, Dominic C. Y. Foo   +3 more
doaj   +1 more source

Lipid specific and vitamin specific non-MHC restricted T cells: new players in human pathophysiology.

Frontiers in Immunology, 2015
Since initial reports, more than 25 years ago, that T cells recognise lipids in the context on non-polymorphic CD1 molecules, our understanding of antigen presentation to non-peptide specific T cell populations has deepened.
Mariolina eSalio, Vincenzo eCerundolo
doaj   +1 more source

Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b

Nature Communications, 2022
MR1 functions as an antigen presenting protein on cells in addition to MAIT cells. Here the authors use an early T cell-specific Bcl11b-deficient mouse that develops autoimmunity through a population of nonconventional MR1-restricted T cells and ...
Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B. Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki   +17 more
doaj   +1 more source

The Diverse Family of MR1-Restricted T Cells [PDF]

The Journal of Immunology, 2018
Abstract Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function.
Nicholas A Gherardin, James McCluskey, Jamie Rossjohn, Dale I Godfrey   +3 more
openaire   +2 more sources

4‐1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions

Immunology &Cell Biology, EarlyView.
4‐1BB is a highly expressed TNFRSF co‐stimulatory receptor on MAIT cells upon activation. Expression and signaling via 4‐1BB enhance activation and provide co‐stimulation, boosting MAIT cell effector responses to TCR‐mediated activation. ABSTRACT Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells that recognize microbe ...
Lamichhane R, Williams J, Tirand C, Fouillé R, Wedlock LE, Poudel A, Webley MC, Hannaway RF, Ussher JE   +8 more
wiley   +1 more source