Results 61 to 70 of about 6,919 (168)

When machines join the moral circle: The persona effect of generative AI agents in collaborative reasoning

British Journal of Educational Technology, EarlyView.
Abstract Generative AI is increasingly positioned as a peer in collaborative learning, yet its effects on ethical deliberation remain unclear. We report a between‐subjects experiment with university students (N = 217) who discussed an autonomous‐vehicle dilemma in triads under three conditions: human‐only control, supportive AI teammate or contrarian ...
Yueqiao Jin, Roberto Martinez‐Maldonado, Wanruo Shi, Songjie Huang, Mingmin Zheng, Xinbin Han, Dragan Gasevic, Lixiang Yan   +7 more
wiley   +1 more source

The Diverse Family of MR1-Restricted T Cells [PDF]

The Journal of Immunology, 2018
Abstract Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function.
Nicholas A Gherardin, James McCluskey, Jamie Rossjohn, Dale I Godfrey   +3 more
openaire   +2 more sources

Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection.

PLoS Pathogens
MR1 is a ubiquitously expressed MHC-Ib molecule that presents microbial metabolites to MR1-restricted T cells, but there are differences in the antigen presentation pathway of an intracellular microbe compared to exogenously delivered antigen.
Elham Karamooz, Se-Jin Kim, Jessie C Peterson, Allison E Tammen, Shogo Soma, Aviva C R Soll, Erin W Meermeier, Sharon Khuzwayo, David M Lewinsohn   +8 more
doaj   +1 more source

Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b

Nature Communications, 2022
MR1 functions as an antigen presenting protein on cells in addition to MAIT cells. Here the authors use an early T cell-specific Bcl11b-deficient mouse that develops autoimmunity through a population of nonconventional MR1-restricted T cells and ...
Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B. Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki   +17 more
doaj   +1 more source

Myelodysplasia‐Related Gene Mutation Burden Is Associated With Complete Remission After Induction Therapy in Acute Myeloid Leukemia, Not Otherwise Specified: Reclassification According to the Updated Classifications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Updated classifications incorporating myelodysplasia‐related (MR) gene mutations reclassify many cases previously diagnosed as acute myeloid leukemia, not otherwise specified (AML, NOS). We evaluated the clinical significance of MR gene mutation burden, defined by mutation number and variant allele frequency (VAF), in AML, NOS ...
Taegeun Lee, Daehyun Chu, Miyoung Kim, Young‐Uk Cho, Sang‐Hyun Hwang, Je‐Hwan Lee, Yunsuk Choi, Eun‐Ji Choi, Ho Joon Im, Hyery Kim, Seongsoo Jang   +10 more
wiley   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, EarlyView.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

Adoptive T Cell Therapy Targeting CD1 and MR1 [PDF]

Frontiers in Immunology, 2015
Adoptive T cell immunotherapy has demonstrated clinically relevant efficacy in treating malignant and infectious diseases. However, much of these therapies have been focused on enhancing, or generating de novo, effector functions of conventional T cells recognizing HLA molecules.
Tingxi eGuo, Tingxi eGuo, Kenji eChamoto, Naoto eHirano, Naoto eHirano   +4 more
openaire   +3 more sources

Dosimetric effects of adaptive prostate cancer radiotherapy in an MR-linac workflow

Radiation Oncology, 2020
Background The purpose was to evaluate the dosimetric effects in prostate cancer treatment caused by anatomical changes occurring during the time frame of adaptive replanning in a magnetic resonance linear accelerator (MR-linac) workflow.
Annika Mannerberg, Emilia Persson, Joakim Jonsson, Christian Jamtheim Gustafsson, Adalsteinn Gunnlaugsson, Lars E. Olsson, Sofie Ceberg   +6 more
doaj   +1 more source

A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus

Frontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes that are restricted by major histocompatibility complex-related molecule 1 (MR1).
Goh Murayama, Goh Murayama, Asako Chiba, Hitoshi Suzuki, Atsushi Nomura, Tomohiro Mizuno, Taiga Kuga, Taiga Kuga, Shinji Nakamura, Hirofumi Amano, Sachiko Hirose, Ken Yamaji, Yusuke Suzuki, Naoto Tamura, Sachiko Miyake   +14 more
doaj   +1 more source

Study of the Frequency of Mononuclear Cells Expressing MR1 Protein in the Synovial Fluid of Patients with Rheumatoid Arthritis [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder with a prevalence of 0.5 to 1 percent in the population. Recently, a population of immune cells known as mucosal-associated invariant T cells (MAIT cells) has been ...
Vahid Zare, ali shams, Mohammad Taher tahoori, ALI dehghan   +3 more
doaj