Results 31 to 40 of about 8,186 (190)

MAIT cell recognition of MR1 on bacterially infected and uninfected cells. [PDF]

PLoS ONE, 2013
Mucosal-associated invariant T cells are a unique population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1.
Mary H Young, Lance U'Ren, Shouxiong Huang, Thierry Mallevaey, James Scott-Browne, Frances Crawford, Olivier Lantz, Ted H Hansen, John Kappler, Philippa Marrack, Laurent Gapin   +10 more
doaj   +1 more source

Covering All the Bases: Complementary MR1 Antigen Presentation Pathways Sample Diverse Antigens and Intracellular Compartments

Frontiers in Immunology, 2020
The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells.
Corinna Kulicke, Corinna Kulicke, Elham Karamooz, Elham Karamooz, David Lewinsohn, David Lewinsohn, David Lewinsohn, David Lewinsohn, Melanie Harriff, Melanie Harriff, Melanie Harriff   +10 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells Are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Mucosal‐associated invariant T (MAIT) cells have been associated with inflammation in several autoimmune diseases. However, their relation to ischemic stroke remains unclear.
Sho Nakajima, Ryota Tanaka, Kazuo Yamashiro, Asako Chiba, Daisuke Noto, Toshiki Inaba, Naohide Kurita, Nobukazu Miyamoto, Takuma Kuroki, Hideki Shimura, Yuji Ueno, Takao Urabe, Sachiko Miyake, Nobutaka Hattori   +13 more
doaj   +1 more source

Activated Mucosal-associated Invariant T Cells Have a Pathogenic Role in a Murine Model of Inflammatory Bowel DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Mucosal-associated invariant T (MAIT) cells are innate-like T cells restricted by major histocompatibility complex-related molecule 1 (MR1) and express a semi-invariant T cell receptor. Previously, we reported the activation status
Yusuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Sachiko Miyake   +10 more
doaj   +1 more source

Fine Mapping of Rice Specific MR1, a Gene Determines Palea Identity

Frontiers in Plant Science, 2022
The hull (palea and lemma) is the specific organ of grass florets. Although many genes related to the hull development have been cloned, the genetic mechanisms behind the development are still unclear, and the evolutionary relationship has different ...
Wei Xie, Wei Liu, Xiaoqi Yu, Dali Zeng, Deyong Ren   +4 more
doaj   +1 more source

Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis

Journal of Neuroinflammation, 2023
Background Neuroinflammation is an important feature of Alzheimer’s disease (AD). Understanding which aspects of the immune system are important in AD may lead to new therapeutic approaches.
Season K. Wyatt-Johnson, Holly N. Kersey, Juan F. Codocedo, Kathy L. Newell, Gary E. Landreth, Bruce T. Lamb, Adrian L. Oblak, Randy R. Brutkiewicz   +7 more
doaj   +1 more source

MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto

iScience, 2020
Summary: Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic.
Edwin Leeansyah, Ying Ying Hey, Wan Rong Sia, Justin Han Jia Ng, Muhammad Yaaseen Gulam, Caroline Boulouis, Feng Zhu, Matae Ahn, Jeffrey Y.W. Mak, David P. Fairlie, Andrea Lay Hoon Kwa, Johan K. Sandberg, Lin-Fa Wang   +12 more
doaj   +1 more source

CD1d- and MR1-Restricted T Cells in Sepsis [PDF]

Frontiers in Immunology, 2015
Dysregulated immune responses to infection, such as those encountered in sepsis, can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even under optimal critical care. Recent studies have implicated unconventional, innate-like T lymphocytes,
Peter A. Szabo, Ram V. Anantha, Ram V. Anantha, Christopher R. Shaler, John K. McCormick, S.M. Mansour eHaeryfar, S.M. Mansour eHaeryfar   +6 more
openaire   +3 more sources

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage [PDF]

Science Immunology, 2018
A diverse array of microbial metabolites binds to MR1 and selectively activates MR1-restricted T cells.
Melanie J. Harriff, Curtis McMurtrey, Cara A. Froyd, Haihong Jin, Meghan Cansler, Megan Null, Aneta Worley, Erin W. Meermeier, Gwendolyn Swarbrick, Aaron Nilsen, Deborah A. Lewinsohn, William Hildebrand, Erin J. Adams, David M. Lewinsohn   +13 more
openaire   +2 more sources

Functionally diverse human T cells recognize non-microbial antigens presented by MR1

eLife, 2017
MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages.
Marco Lepore, Artem Kalinichenko, Salvatore Calogero, Pavanish Kumar, Bhairav Paleja, Mathias Schmaler, Vipin Narang, Francesca Zolezzi, Michael Poidinger, Lucia Mori, Gennaro De Libero   +10 more
doaj   +1 more source