Results 31 to 40 of about 6,919 (168)
Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis
Journal of Neuroinflammation, 2023 Background Neuroinflammation is an important feature of Alzheimer’s disease (AD). Understanding which aspects of the immune system are important in AD may lead to new therapeutic approaches.
Season K. Wyatt-Johnson +7 more
doaj +1 more source
Fine Mapping of Rice Specific MR1, a Gene Determines Palea Identity
Frontiers in Plant Science, 2022 The hull (palea and lemma) is the specific organ of grass florets. Although many genes related to the hull development have been cloned, the genetic mechanisms behind the development are still unclear, and the evolutionary relationship has different ...
Wei Xie +4 more
doaj +1 more source
CD1d- and MR1-Restricted T Cells in Sepsis [PDF]
Frontiers in Immunology, 2015 Dysregulated immune responses to infection, such as those encountered in sepsis, can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even under optimal critical care. Recent studies have implicated unconventional, innate-like T lymphocytes,
Peter A. Szabo +6 more
openaire +3 more sources
iScience, 2020 Summary: Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic.
Edwin Leeansyah +12 more
doaj +1 more source
MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage [PDF]
Science Immunology, 2018 A diverse array of microbial metabolites binds to MR1 and selectively activates MR1-restricted T cells.
Melanie J. Harriff +13 more
openaire +2 more sources
Functionally diverse human T cells recognize non-microbial antigens presented by MR1
eLife, 2017 MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages.
Marco Lepore +10 more
doaj +1 more source
TTC21B: From Modifier to Causative Gene in Joubert Syndrome
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Biallelic pathogenic variants in TTC21B, encoding the retrograde intraflagellar transport protein IFT139, are a known cause of renal and skeletal ciliopathies. Single heterozygous variants in this gene were found to be enriched in a cohort of patients with various ciliopathy phenotypes, including three individuals with Joubert syndrome (JS), a
Valentina Serpieri +5 more
wiley +1 more source
Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection.
PLoS ONE, 2019 Clostridium difficile (Cd) infection (CDI) typically occurs after antibiotic usage perturbs the gut microbiota. Mucosa-associated invariant T cells (MAIT) are found in the gut and their development is dependent on Major histocompatibility complex-related
Ashley D Smith +14 more
doaj +1 more source
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis &Rheumatology, EarlyView.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source
Generation of MR1-Restricted T Cell Clones by Limiting Dilution Cloning of MR1 Tetramer+ Cells [PDF]
, 2019 Tetramers are a powerful tool for identification of T cell subsets that are restricted by specific antigen presenting molecules and their cognate antigens. The generation of T cell clones from specific T cell subsets allows for further investigation of the phenotype and function of these cells.
Meghan, Cansler +5 more
openaire +2 more sources