Results 11 to 20 of about 6,919 (168)

Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

Frontiers in Oncology
BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-
Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Sophie Papa, Jamie Rossjohn, Jamie Rossjohn, Duncan Howie, Joseph Dukes   +28 more
doaj   +4 more sources

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

Scientific Reports, 2022
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection.
Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff   +14 more
doaj   +3 more sources

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

Frontiers in Immunology
IntroductionThe MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted
Richard J. Suckling, Cevriye Pamukcu, Robert Alan Simmons, Daniel Fonseca, Emma Grant, Rory Harrison, Saher A. Shaikh, Rahul C. Khanolkar, Hemza Ghadbane, Andrew Creese, Miriam Hock, Thomas G. Gligoris, Marco Lepore, Vijaykumar Karuppiah, Mariolina Salio   +14 more
doaj   +3 more sources

IFNγ regulates MR1 transcription and antigen presentation

Frontiers in Immunology
IntroductionAntigen presentation molecules play key roles in T cell immunity. Multiple complementary pathways are known to regulate classical MHC-I molecules at transcriptional, translational, and post-translational levels.
Megan E. Huber, Megan E. Huber, Emily A. Larson, Taylor N. Lust, Chelsea M. Heisler, Melanie J. Harriff, Melanie J. Harriff, Melanie J. Harriff   +7 more
doaj   +3 more sources

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation

Communications Biology, 2022
MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways.
Corinna A. Kulicke, Gwendolyn M. Swarbrick, Nicole A. Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Taylor N. Lust, Chelsea M. Heisler, Megan E. Huber, Jason R. Krawic, Laurisa M. Ankley, Savannah K. McBride, Fikadu G. Tafesse, Andrew J. Olive, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff   +21 more
doaj   +3 more sources

Diversity and hallmarks of metabolites surveyed by MR1

Immunobiology
Mucosal-associated invariant T (MAIT) cells are one of the innate T cell subset. They are known to contribute to anti-bacterial response by recognizing bacterial components with invariant TCRs which are presented on a monomorphic antigen presenting ...
Emi Ito, Sho Yamasaki
doaj   +3 more sources

Mucosal-Associated Invariant T Cells in Health and Disease. [PDF]

MedComm (2020)
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Zhao Y, Ou FM, Liang D, Gao Y, Li QQ, Kuang YQ.   +5 more
europepmc   +2 more sources

Acute myeloid leukemia cell therapy by combining MR1-modulating drugs and MR1 T cells

Blood Immunology & Cellular Therapy
: MR1-restricted T (MR1T) cells are a subset of unconventional T cells that recognize metabolite-derived antigens presented by the oligomorphic major histocompatibility complex class I–related molecule MR1. MR1T cells express a polyclonal T-cell receptor
Natalie Kehrer, Aisha Beshirova, Daniel Constantin, Vladimir Nosi, Marco Stringhini, Marine Cordonnier, Verena Schaefer, Giulia Montanelli, Andrew Chancellor, Alexander Tzankov, Katja Seipel, Raphael Battegay, Thomas Pabst, Jakob Passweg, Martin Carroll, Alessandro Vacchini, Lucia Mori, Jürg Schwaller, Gennaro De Libero   +18 more
doaj   +2 more sources

MR1: An unconventional twist in the tail

Journal of Cell Biology, 2022
MR1 is a conserved molecule that binds microbial vitamin B metabolites and presents them to unconventional T cells. Lim and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202110125) uncover the role of AP2 in ensuring MR1 surface presentation, which relies on an atypical motif within the MR1 cytoplasmic tail.
Phalora, P, Klenerman, P
openaire   +3 more sources

Expression and trafficking of MR1 [PDF]

Immunology, 2017
SummaryMHC class I‐related gene protein (MR1) is a non‐polymorphic MHC class IB antigen‐presenting molecule that is the restricting molecule for mucosal‐associated invariant T (MAIT) cells, a prominent population of innate‐like antibacterial T cells. The MAIT cell–MR1 axis represents a new paradigm in antigen presentation, with the MR1 ligand derived ...
Rajesh Lamichhane, James E. Ussher
openaire   +2 more sources