Results 11 to 20 of about 27,223 (192)

Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

Frontiers in Oncology
BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-
Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Sophie Papa, Jamie Rossjohn, Jamie Rossjohn, Duncan Howie, Joseph Dukes   +28 more
doaj   +4 more sources

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

Scientific Reports, 2022
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection.
Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff   +14 more
doaj   +3 more sources

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

Frontiers in Immunology
IntroductionThe MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted
Richard J. Suckling, Cevriye Pamukcu, Robert Alan Simmons, Daniel Fonseca, Emma Grant, Rory Harrison, Saher A. Shaikh, Rahul C. Khanolkar, Hemza Ghadbane, Andrew Creese, Miriam Hock, Thomas G. Gligoris, Marco Lepore, Vijaykumar Karuppiah, Mariolina Salio   +14 more
doaj   +3 more sources

MR1-Restricted T Cells Are Unprecedented Cancer Fighters [PDF]

Frontiers in Immunology, 2020
Non-polymorphic MHC class I-related molecule MR1 presents antigenic bacterial metabolites to mucosal-associated invariant T (MAIT) cells and self-antigens to MR1-restricted T (MR1T) cells.
Alessandro Vacchini, Andrew Chancellor, Julian Spagnuolo, Lucia Mori, Gennaro De Libero   +4 more
doaj   +3 more sources

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation

Communications Biology, 2022
MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways.
Corinna A. Kulicke, Gwendolyn M. Swarbrick, Nicole A. Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Taylor N. Lust, Chelsea M. Heisler, Megan E. Huber, Jason R. Krawic, Laurisa M. Ankley, Savannah K. McBride, Fikadu G. Tafesse, Andrew J. Olive, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff   +21 more
doaj   +3 more sources

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

Frontiers in Immunology
The TCR-mediated activation of T cells expressing the TCR Vγ9Vδ2 relies on an innate-like mechanism involving the butyrophilin 3A1, 3A2 and 2A1 molecules and phospho-antigens, without the participation of classical antigen-presenting molecules.
José Pedro Loureiro, Alessandro Vacchini, Giuliano Berloffa, Jan Devan, Verena Schaefer, Vladimir Nosi, Rodrigo Colombo, Aisha Beshirova, Giulia Montanelli, Benedikt Meyer, Timothy Sharpe, Andrew Chancellor, Mike Recher, Lucia Mori, Gennaro De Libero   +14 more
doaj   +3 more sources

Unconventional T cells in anti-cancer immunity [PDF]

Frontiers in Immunology
Unlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related ...
Ariel Laub, Ariel Laub, Nathalia Rodrigues de Almeida, Shouxiong Huang, Shouxiong Huang   +4 more
doaj   +2 more sources

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

Frontiers in Immunology, 2023
IntroductionThe antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells ...
Caroline L. Ashley, Brian P. McSharry, Brian P. McSharry, Hamish E. G. McWilliam, Hamish E. G. McWilliam, Richard J. Stanton, Ceri A. Fielding, Rommel A. Mathias, Rommel A. Mathias, David P. Fairlie, James McCluskey, Jose A. Villadangos, Jose A. Villadangos, Jamie Rossjohn, Jamie Rossjohn, Allison Abendroth, Barry Slobedman   +16 more
doaj   +1 more source

MR1 deficiency enhances IL-17-mediated allergic contact dermatitis

Frontiers in Immunology, 2023
Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells primarily involved in host defense against pathogenic microbes and influence the development of immune-mediated diseases.
Naoya Imahashi, Naoya Imahashi, Masashi Satoh, Masashi Satoh, Emanuela Clemente, Emanuela Clemente, Kazuhisa Yoshino, Mario Di Gioacchino, Mario Di Gioacchino, Kazuya Iwabuchi, Kazuya Iwabuchi   +10 more
doaj   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy [PDF]

MedComm (2020)
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
He W, McMichael A.
europepmc   +2 more sources