Results 11 to 20 of about 8,186 (190)

MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells

Proceedings of the National Academy of Sciences of the United States of America
The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1-restricted T cells expressing more diverse T cell receptors (TCRs), some with anti-tumor reactivity.
Jeremy M Raynes, Wael Awad, Michael N T Souter   +2 more
exaly   +7 more sources

MR1: An unconventional twist in the tail

Journal of Cell Biology, 2022
MR1 is a conserved molecule that binds microbial vitamin B metabolites and presents them to unconventional T cells. Lim and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202110125) uncover the role of AP2 in ensuring MR1 surface presentation, which relies on an atypical motif within the MR1 cytoplasmic tail.
Phalora, P, Klenerman, P
openaire   +5 more sources

MR1-Restricted T Cells in Cancer Immunotherapy [PDF]

Cancers, 2020
Major histocompatibility complex class I-related (MR1) was first identified as a cell membrane protein involved in the development and expansion of a unique set of T cells expressing an invariant T-cell receptor (TCR) α-chain. These cells were initially discovered in mucosal tissues, such as the intestinal mucosa, so they are called mucosal-associated ...
Pedro Flores-Villanueva, Navid Sobhani, Xu Wang, Yong Li   +3 more
openaire   +3 more sources

MR1 deficiency enhances IL-17-mediated allergic contact dermatitis [PDF]

Frontiers in Immunology, 2023
Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells primarily involved in host defense against pathogenic microbes and influence the development of immune-mediated diseases.
Naoya Imahashi, Naoya Imahashi, Masashi Satoh, Masashi Satoh, Emanuela Clemente, Emanuela Clemente, Kazuhisa Yoshino, Mario Di Gioacchino, Mario Di Gioacchino, Kazuya Iwabuchi, Kazuya Iwabuchi   +10 more
doaj   +2 more sources

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells [PDF]

Journal of Experimental Medicine, 2022
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I)–related protein 1 (MR1). Most MAIT cells in human peripheral blood express CD8αα or CD8αβ coreceptors, and the binding site for CD8 on MHC-I molecules is relatively ...
Michael N.T. Souter, Wael Awad, Shihan Li, Troi J. Pediongco, Bronwyn S. Meehan, Lucy J. Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T. Praveena, Jacinta Wubben, Jie Lin, Lucy C. Sullivan, George O. Lovrecz, Jeffrey Y.W. Mak, Ligong Liu, Lyudmila Kostenko, Katherine Kedzierska, Alexandra J. Corbett, David P. Fairlie, Andrew G. Brooks, Nicholas A. Gherardin, Adam P. Uldrich, Zhenjun Chen, Jamie Rossjohn, Dale I. Godfrey, James McCluskey, Daniel G. Pellicci, Sidonia B.G. Eckle   +31 more
core   +7 more sources

Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner

Cells
The MHC class I-related 1 (MR1) molecule is a non-polymorphic antigen-presenting molecule that presents several metabolites to MR1-restricted T cells, including mucosal-associated invariant T (MAIT) cells.
Abdul Hayee, Eiji Kobayashi, Chihiro Motozono   +2 more
exaly   +3 more sources

MR1-Restricted T Cells Are Unprecedented Cancer Fighters

Frontiers in Immunology, 2020
Non-polymorphic MHC class I-related molecule MR1 presents antigenic bacterial metabolites to mucosal-associated invariant T (MAIT) cells and self-antigens to MR1-restricted T (MR1T) cells.
Alessandro Vacchini, Andrew Chancellor, Julian Spagnuolo   +2 more
exaly   +3 more sources

Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development [PDF]

Frontiers in Immunology
Flavin and deazaflavin biosynthesis are highly conserved pathways in mycobacteria, including in Mycobacterium tuberculosis (M.tb). Flavin biosynthesis on one hand is required to produce FMN and FAD, two essential cofactors required to support the flavin ...
Nurudeen Oketade, Melissa D. Chengalroyen, Dylan Kain, David M. Lewinsohn, David M. Lewinsohn, Karen M. Dobos   +5 more
doaj   +2 more sources

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

Frontiers in Immunology
IntroductionThe MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted
Richard J. Suckling, Cevriye Pamukcu, Robert Alan Simmons, Daniel Fonseca, Emma Grant, Rory Harrison, Saher A. Shaikh, Rahul C. Khanolkar, Hemza Ghadbane, Andrew Creese, Miriam Hock, Thomas G. Gligoris, Marco Lepore, Vijaykumar Karuppiah, Mariolina Salio   +14 more
doaj   +3 more sources

MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens [PDF]

Cell Reports: Methods
Summary: Major histocompatibility complex class I-related protein 1 (MR1) plays a central role in the immune recognition of infected cells and can mediate T cell detection of cancer. Knowledge of the nature of the ligands presented by MR1 is still sparse
Thierry Schmidlin, Enas Behiry, Hannah Thomas, Garry Dolton, Fabio Marino, Samiul Hasan, Magdalena von Essen, Rose M. Gathungu, Barbara A. Steigenberger, Hayden Selvadurai, Joseph Dukes, Paul E. Brennan, Owen B. Spiller, Jonathan D. Silk, Andrew K. Sewell, Nicola Ternette   +15 more
doaj   +2 more sources