Results 21 to 30 of about 8,186 (190)

Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection. [PDF]

PLoS Pathogens
MR1 is a ubiquitously expressed MHC-Ib molecule that presents microbial metabolites to MR1-restricted T cells, but there are differences in the antigen presentation pathway of an intracellular microbe compared to exogenously delivered antigen.
Elham Karamooz, Se-Jin Kim, Jessie C Peterson, Allison E Tammen, Shogo Soma, Aviva C R Soll, Erin W Meermeier, Sharon Khuzwayo, David M Lewinsohn   +8 more
doaj   +2 more sources

Targeting the MR1-MAIT Cell Axis for Vaccination Against Infectious Disease [PDF]

Vaccines
Mucosal-associated invariant T (MAIT) cells exist in high numbers in the body and have a unique and highly conserved T cell receptor (TCR). They can be activated in a TCR-dependent manner by ligands presented on the monomorphic protein MHC class I ...
Mattie S. M. Timmer, Lisa M. Connor, Bridget L. Stocker   +2 more
doaj   +2 more sources

Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells [PDF]

Proceedings of the National Academy of Sciences
Mitochondria coordinate several metabolic pathways, producing metabolites that influence the immune response in various ways. It remains unclear whether mitochondria impact antigen presentation by the MHC-class-I-related antigen-presenting molecule, MR1, which presents small molecules to MR1-restricted T-lymphocytes.
Gennaro Prota, Giuliano Berloffa, Wael Awad, Alessandro Vacchini, Andrew Chancellor, Verena Schaefer, Daniel Constantin, Dene R. Littler, Rodrigo Colombo, Vladimir Nosi, Lucia Mori, Jamie Rossjohn, Gennaro De Libero   +12 more
openaire   +3 more sources

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

Frontiers in Immunology
The TCR-mediated activation of T cells expressing the TCR Vγ9Vδ2 relies on an innate-like mechanism involving the butyrophilin 3A1, 3A2 and 2A1 molecules and phospho-antigens, without the participation of classical antigen-presenting molecules.
José Pedro Loureiro, Alessandro Vacchini, Giuliano Berloffa, Jan Devan, Verena Schaefer, Vladimir Nosi, Rodrigo Colombo, Aisha Beshirova, Giulia Montanelli, Benedikt Meyer, Timothy Sharpe, Andrew Chancellor, Mike Recher, Lucia Mori, Gennaro De Libero   +14 more
doaj   +3 more sources

Diversity and hallmarks of metabolites surveyed by MR1

Immunobiology
Mucosal-associated invariant T (MAIT) cells are one of the innate T cell subset. They are known to contribute to anti-bacterial response by recognizing bacterial components with invariant TCRs which are presented on a monomorphic antigen presenting ...
Emi Ito, Sho Yamasaki
doaj   +3 more sources

Expression and trafficking of MR1 [PDF]

Immunology, 2017
SummaryMHC class I‐related gene protein (MR1) is a non‐polymorphic MHC class IB antigen‐presenting molecule that is the restricting molecule for mucosal‐associated invariant T (MAIT) cells, a prominent population of innate‐like antibacterial T cells. The MAIT cell–MR1 axis represents a new paradigm in antigen presentation, with the MR1 ligand derived ...
Rajesh Lamichhane, James E. Ussher
openaire   +2 more sources

MR1, an immunological periscope of cellular metabolism [PDF]

International Immunology, 2021
AbstractThe discovery that major histocompatibility complex (MHC) class I-related molecule 1 (MR1) presents microbial antigens to mucosal-associated invariant T (MAIT) cells was a significant scientific milestone in the last decade. Surveillance for foreign metabolically derived antigens added a new class of target structures for immune recognition ...
Chancellor, Andrew, Vacchini, Alessandro, De Libero, Gennaro   +2 more
openaire   +2 more sources

Mammalian CD1 and MR1 genes [PDF]

Immunogenetics, 2016
All higher vertebrates share the fundamental components of the adaptive immune system: the B cell receptor, the T cell receptor, and classical MHC proteins. At a more detailed level, their immune systems vary considerably, especially with respect to the non-polymorphic MHC class I-like proteins.
Reinink, Peter, Van Rhijn, Ildiko
openaire   +5 more sources

Identification of Novel MR1 Ligands Derived from Herbal Medicines by MR1-Presentation Reporter Screening and Their Structure-Activity Relationship

, 2022
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are modulated by ligands presented on MHC class I-related proteins (MR1). These cells have attracted attention as potential drug targets because of their involvement in the initial ...
Shinya, Oishi, Hiroaki, Ohno, Hideaki, Kakeya, Takuro, Matsuoka, Shinsuke, Inuki, Sho, Yamasaki, Norihito, Arichi, Akira, Hattori   +7 more
core   +1 more source

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells. [PDF]

PLoS Pathogens, 2016
Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other mucosal tissues, have Th1 effector capacity positioning them to play a critical role in the early immune response to intracellular pathogens, including ...
Melanie J Harriff, Elham Karamooz, Ansen Burr, Wilmon F Grant, Elizabeth T Canfield, Michelle L Sorensen, Luis F Moita, David M Lewinsohn   +7 more
doaj   +1 more source