Results 21 to 30 of about 6,919 (168)

MR1, an immunological periscope of cellular metabolism [PDF]

International Immunology, 2021
AbstractThe discovery that major histocompatibility complex (MHC) class I-related molecule 1 (MR1) presents microbial antigens to mucosal-associated invariant T (MAIT) cells was a significant scientific milestone in the last decade. Surveillance for foreign metabolically derived antigens added a new class of target structures for immune recognition ...
Chancellor, Andrew, Vacchini, Alessandro, De Libero, Gennaro   +2 more
openaire   +2 more sources

Mammalian CD1 and MR1 genes [PDF]

Immunogenetics, 2016
All higher vertebrates share the fundamental components of the adaptive immune system: the B cell receptor, the T cell receptor, and classical MHC proteins. At a more detailed level, their immune systems vary considerably, especially with respect to the non-polymorphic MHC class I-like proteins.
Reinink, Peter, Van Rhijn, Ildiko
openaire   +5 more sources

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells. [PDF]

PLoS Pathogens, 2016
Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other mucosal tissues, have Th1 effector capacity positioning them to play a critical role in the early immune response to intracellular pathogens, including ...
Melanie J Harriff, Elham Karamooz, Ansen Burr, Wilmon F Grant, Elizabeth T Canfield, Michelle L Sorensen, Luis F Moita, David M Lewinsohn   +7 more
doaj   +1 more source

MAIT cell recognition of MR1 on bacterially infected and uninfected cells. [PDF]

PLoS ONE, 2013
Mucosal-associated invariant T cells are a unique population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1.
Mary H Young, Lance U'Ren, Shouxiong Huang, Thierry Mallevaey, James Scott-Browne, Frances Crawford, Olivier Lantz, Ted H Hansen, John Kappler, Philippa Marrack, Laurent Gapin   +10 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells Are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Mucosal‐associated invariant T (MAIT) cells have been associated with inflammation in several autoimmune diseases. However, their relation to ischemic stroke remains unclear.
Sho Nakajima, Ryota Tanaka, Kazuo Yamashiro, Asako Chiba, Daisuke Noto, Toshiki Inaba, Naohide Kurita, Nobukazu Miyamoto, Takuma Kuroki, Hideki Shimura, Yuji Ueno, Takao Urabe, Sachiko Miyake, Nobutaka Hattori   +13 more
doaj   +1 more source

Covering All the Bases: Complementary MR1 Antigen Presentation Pathways Sample Diverse Antigens and Intracellular Compartments

Frontiers in Immunology, 2020
The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells.
Corinna Kulicke, Corinna Kulicke, Elham Karamooz, Elham Karamooz, David Lewinsohn, David Lewinsohn, David Lewinsohn, David Lewinsohn, Melanie Harriff, Melanie Harriff, Melanie Harriff   +10 more
doaj   +1 more source

Activated Mucosal-associated Invariant T Cells Have a Pathogenic Role in a Murine Model of Inflammatory Bowel DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Mucosal-associated invariant T (MAIT) cells are innate-like T cells restricted by major histocompatibility complex-related molecule 1 (MR1) and express a semi-invariant T cell receptor. Previously, we reported the activation status
Yusuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Sachiko Miyake   +10 more
doaj   +1 more source

Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries

Frontiers in Immunology, 2020
Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important ...
Alexandra J. Corbett, Wael Awad, Wael Awad, Huimeng Wang, Huimeng Wang, Zhenjun Chen   +5 more
doaj   +1 more source

MR1-Restricted T Cells in Cancer Immunotherapy [PDF]

Cancers, 2020
Major histocompatibility complex class I-related (MR1) was first identified as a cell membrane protein involved in the development and expansion of a unique set of T cells expressing an invariant T-cell receptor (TCR) α-chain. These cells were initially discovered in mucosal tissues, such as the intestinal mucosa, so they are called mucosal-associated ...
Pedro Flores-Villanueva, Navid Sobhani, Xu Wang, Yong Li   +3 more
openaire   +2 more sources

MR1-Restricted T Cells Are Unprecedented Cancer Fighters

Frontiers in Immunology, 2020
Non-polymorphic MHC class I-related molecule MR1 presents antigenic bacterial metabolites to mucosal-associated invariant T (MAIT) cells and self-antigens to MR1-restricted T (MR1T) cells.
Alessandro Vacchini, Andrew Chancellor, Julian Spagnuolo, Lucia Mori, Gennaro De Libero   +4 more
doaj   +1 more source