Results 21 to 30 of about 27,223 (192)

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources

Mammalian CD1 and MR1 genes [PDF]

Immunogenetics, 2016
All higher vertebrates share the fundamental components of the adaptive immune system: the B cell receptor, the T cell receptor, and classical MHC proteins. At a more detailed level, their immune systems vary considerably, especially with respect to the non-polymorphic MHC class I-like proteins.
Reinink, Peter, Van Rhijn, Ildiko
openaire   +4 more sources

MR1, an immunological periscope of cellular metabolism [PDF]

International Immunology, 2021
AbstractThe discovery that major histocompatibility complex (MHC) class I-related molecule 1 (MR1) presents microbial antigens to mucosal-associated invariant T (MAIT) cells was a significant scientific milestone in the last decade. Surveillance for foreign metabolically derived antigens added a new class of target structures for immune recognition ...
Chancellor, Andrew, Vacchini, Alessandro, De Libero, Gennaro   +2 more
openaire   +2 more sources

The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell development. [PDF]

Immunol Cell Biol
In this study, we found that the nuclear factor kappa light chain enhancer in activated B cells (NF‐κB) transcription factor RelA, and to a lesser extent NF‐κB1 and NF‐κB2, are key regulators of mucosal‐associated invariant T (MAIT)‐cell development and differentiation.
Fulford TS, Koay HF, Grumont R, Johnson DN, Scheer S, Nel HJ, Thomas R, Mak JY, Fairlie DP, Teh CE, Gray DH, Bryant VL, Zaph C, O'Reilly LA, Gerondakis S, Godfrey DI.   +15 more
europepmc   +2 more sources

Expression and trafficking of MR1 [PDF]

Immunology, 2017
SummaryMHC class I‐related gene protein (MR1) is a non‐polymorphic MHC class IB antigen‐presenting molecule that is the restricting molecule for mucosal‐associated invariant T (MAIT) cells, a prominent population of innate‐like antibacterial T cells. The MAIT cell–MR1 axis represents a new paradigm in antigen presentation, with the MR1 ligand derived ...
Rajesh Lamichhane, James E. Ussher
openaire   +2 more sources

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells [PDF]

, 2017
The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified
A Kurioka, AJ Corbett, AJ McCoy, AL Szymczak, Alexandra J Corbett, Andrew N Keller, Anthony W Purcell, Bronwyn S Meehan, BY Chua, Criselle D'Souza, Dale I Godfrey, David P Fairlie, DC Chatterji, DI Godfrey, E Treiner, EY Jones, F Koning, F Tilloy, HEG McWilliam, Huimeng Wang, I Kawachi, I Van Rhijn, IJ Skypala, James McCluskey, Jamie Rossjohn, JE Ussher, Jeffrey Y W Mak, L Kjer-Nielsen, L Le Bourhis, Lars Kjer-Nielsen, Ligong Liu, Lyudmila Kostenko, M Bharadwaj, M Dusseaux, M Lepore, M Salio, MC Gold, MD Winn, MHM Heemskerk, NA Gherardin, Nicholas A Gherardin, NM Davies, O Patel, P Emsley, PCD Hawkins, PD Adams, PF Fehlner, PJ Hashkes, PT Illing, R Reantragoon, R Reantragoon, Richard W Birkinshaw, S Gras, S Gras, S Huang, S Zelcer, SB Eckle, SB Eckle, Sidonia B G Eckle, SK Hoiseth, Troi Pediongco, V Krasniqi, VB Chen, VC Romão, Victoria A Hughes, Weijun Xu, WXDS Kabsch, Zhenjun Chen   +67 more
core   +2 more sources

MR1: An unconventional twist in the tail

Journal of Cell Biology, 2022
MR1 is a conserved molecule that binds microbial vitamin B metabolites and presents them to unconventional T cells. Lim and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202110125) uncover the role of AP2 in ensuring MR1 surface presentation, which relies on an atypical motif within the MR1 cytoplasmic tail.
Phalora, P, Klenerman, P
openaire   +3 more sources

MAIT cell recognition of MR1 on bacterially infected and uninfected cells. [PDF]

PLoS ONE, 2013
Mucosal-associated invariant T cells are a unique population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1.
Mary H Young, Lance U'Ren, Shouxiong Huang, Thierry Mallevaey, James Scott-Browne, Frances Crawford, Olivier Lantz, Ted H Hansen, John Kappler, Philippa Marrack, Laurent Gapin   +10 more
doaj   +1 more source

A Complex Neurodevelopmental Phenotype Resembling a Chromatinopathy With Concurrent 7p Duplication and 10p Deletion Involving ZMYND11: A Case Report and Literature Review. [PDF]

Mol Genet Genomic Med
This study presents a 25‐year‐old female with global developmental delay, dysmorphic features, and a complex phenotype arising from co‐occurring chromosomal anomalies: a 6 Mb 10p15.3p14 microdeletion involving the ZMYND11 gene and a 7.6 Mb 7p22.3p21.3 microduplication.
Minale EMP, Martone S, Criscuolo C, Marra R, Lasorsa VA, Ruggiero R, Suero T, Capasso M, Andolfo I, Iolascon A, Russo R, Pinelli M.   +11 more
europepmc   +2 more sources

Renormalisation Group Analysis of Single Right-handed Neutrino Dominance [PDF]

, 2000
We perform a renormalisation group (RG) analysis of neutrino masses and mixing angles in the see-saw mechanism in the minimal supersymmetric standard model with three right-handed neutrinos, including the effects of the heavy neutrino thresholds.
Altarelli, Altarelli, Altarelli, Altarelli, Altarelli, Apollonio, Babu, Bahcall, Balaji, Barbieri, Binetruy, Casas, Chankowski, Dreiner, Ellis, Ellis, Elwood, Fritzsch, Fritzsch, Froggatt, Gell-Mann, Green, Gribov, Haba, Harvey, Ibanez, Irges, Kaus, King, King, King, Leontaris, Lola, Maki, Mikheyev, Mohapatra, N. Nimai Singh, S.F. King, Wetterich, Wolfenstein, Wolfenstein, Yanagida   +41 more
core   +2 more sources