Results 11 to 20 of about 18,685 (221)
Diversification of CD1 molecules shapes lipid antigen selectivity [PDF]
Molecular Biology and Evolution, 2020 AbstractMolecular studies of host-pathogen evolution have largely focused on the consequences of variation at protein-protein interaction surfaces. The potential for other microbe-associated macromolecules to promote arms race dynamics with host factors remains unclear.
Nicole M. Paterson +2 more
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Regulation of CD1 Antigen-presenting Complex Stability [PDF]
Journal of Biological Chemistry, 2010 For major histocompatibility complex class I and II molecules, the binding of specific peptide antigens is essential for assembly and trafficking and is at the center of their quality control mechanism. However, the role of lipid antigen binding in stabilization and quality control of CD1 heavy chain (HC).beta(2)-microglobulin (beta(2)m) complexes is ...
Odyniec, A. N. +5 more
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Role of Group 1 CD1-restricted T Cells in Infectious Disease
Frontiers in Immunology, 2015 The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens ...
Sarah eSiddiqui +2 more
doaj +1 more source
Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein
Biomolecules, 2020 CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less ...
Bruno Cuevas-Zuviría +4 more
doaj +1 more source
Presentation of Lipid Antigens by CD1 Glycoproteins [PDF]
Current Pharmaceutical Design, 2009 CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentation of self and foreign lipid antigens: group 1 (CD1a, CD1b and CD1c) and group 2 (CD1d). Crystal structures of CD1a, CD1b and CD1d in
André, Schiefner, Ian A, Wilson
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Journal of Clinical and Translational Science, 2021 IMPACT: Examining lipid immunity for Mycobacterium tuberculosis in a translatable Guinea pig model may serve as a critical foundation for the creation of an efficacious human lipid based vaccine against tuberculosis.
Macallister Harris +5 more
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Inhibition of CD1 Antigen Presentation by Human Cytomegalovirus [PDF]
Journal of Virology, 2008 ABSTRACTThe betaherpesvirus human cytomegalovirus (HCMV) encodes several molecules that block antigen presentation by the major histocompatibility complex (MHC) proteins. Humans also possess one other family of antigen-presenting molecules, the CD1 family; however, the effect of HCMV on CD1 expression is unknown.
Raftery, M. +6 more
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Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection.
PLoS Pathogens, 2020 Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have ...
Lavanya Visvabharathy +6 more
doaj +1 more source
Immune evasion of the CD1d/NKT cell axis [PDF]
, 2018 Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity.
Brutkiewicz, Randy R. +2 more
core +1 more source
The T cell response to lipid antigens of Mycobacterium tuberculosis
Frontiers in Immunology, 2014 T cells recognize lipid antigens presented by dedicated antigen presenting molecules that belong to the CD1 family. This review discusses the structural properties of CD1 molecules, the nature of mycobacterial lipid antigens, and the phenotypic and ...
Gennaro eDe Libero +2 more
doaj +1 more source