Results 11 to 20 of about 11,539 (211)

CD1 molecules: Beyond antigen presentation

Molecular Immunology
CD1 molecules are well known for their role in binding and presenting lipid antigens to mediate the activation of CD1-restricted T cells. However, much less appreciated is the fact that CD1 molecules can have additional "unconventional" roles which ...
Patricia Barral
exaly   +4 more sources

Role of Donor Unrestricted T Cells (DURTs) in TB Host Defense: Implications for Novel TB Vaccine Development [PDF]

Vaccines
Tuberculosis (TB) is the leading cause of infectious disease-related death globally. Most TB vaccine strategies have focused on conventional CD4 T cell responses, but to date, these have failed to deliver durable sterilizing protection.
Dylan Kain, David Michael Lewinsohn, Deborah Anne Lewinsohn   +2 more
doaj   +2 more sources

Regulation of CD1 Antigen-presenting Complex Stability [PDF]

Journal of Biological Chemistry, 2010
For major histocompatibility complex class I and II molecules, the binding of specific peptide antigens is essential for assembly and trafficking and is at the center of their quality control mechanism.
Tatituri, RV, Brenner, M. B., Michael B. Brenner, Garg, S., Garg, S, Besra, Gurdyal; id_orcid, Brenner, MB, Odyniec, A. N., Barral, DC, Artur N. Odyniec, Raju V. Tatituri, Duarte C. Barral, Barral, D. C., Odyniec, AN, Salil Garg, Gurdyal S. Besra, Besra, G. S., Tatituri, R. V.   +17 more
core   +5 more sources

Sideways lipid presentation by the antigen-presenting molecule CD1c [PDF]

Nature Communications
For the MHC, MR1 and CD1 systems, antigen recognition involves contact of the membrane distal surfaces of both the αβ T cell receptor (TCR) and the antigen-presenting molecule.
Thinh-Phat Cao, Guan-Ru Liao, Tan-Yun Cheng, Yanqiong Chen, Laura Ciacchi, Thomas S. Fulford, Rachel Farquhar, Jade Kollmorgen, Jacob A. Mayfield, Adam P. Uldrich, Emily Zhi Qing Ng, Graham S. Ogg, Dale I. Godfrey, Nicholas A. Gherardin, Yi-Ling Chen, D. Branch Moody, Adam Shahine, Jamie Rossjohn   +17 more
doaj   +3 more sources

CD1: From Molecules to Diseases [version 1; referees: 3 approved] [PDF]

F1000Research, 2017
The human cluster of differentiation (CD)1 system for antigen display is comprised of four types of antigen-presenting molecules, each with a distinct functional niche: CD1a, CD1b, CD1c, and CD1d.
D. Branch Moody, Sara Suliman
doaj   +2 more sources

Insights into the CD1 lipidome [PDF]

Frontiers in Immunology
CD1 isoforms are MHC class I-like molecules that present lipid-antigens to T cells and have been associated with a variety of immune responses. The lipid repertoire bound and presented by the four CD1 isoforms may be influenced by factors such as the ...
Rita Szoke-Kovacs, Rita Szoke-Kovacs, Sophie Khakoo, Peter Gogolak, Mariolina Salio   +4 more
doaj   +2 more sources

Features of the CD1 gene family in rodents and the uniqueness of the immune system of naked mole-rat [PDF]

Biology Direct
Cluster of Differentiation 1 (CD1) proteins are widely expressed throughout jawed vertebrates and present lipid antigens to specific CD1-restricted T lymphocytes.
Konstantin V. Gunbin, Gelina S. Kopeina, Boris Zhivotovsky, Alexey V. Zamaraev   +3 more
doaj   +2 more sources

Nonclassical MHC-I Molecules: Emerging Therapeutic Targets in Next-Generation Immunotherapy. [PDF]

MedComm (2020)
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
He W, McMichael AJ.
europepmc   +2 more sources

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system

Experimental and Molecular Medicine, 2023
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in
Seohyun Kim, Sumin Cho, Ji Hyung Kim
doaj   +1 more source

Mechanisms and Consequences of Antigen Presentation by CD1 [PDF]

Trends in Immunology, 2016
The CD1 proteins are a family of non-polymorphic and MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions. Recent studies have provided new insight into the identity of immunogenic CD1 antigens and the mechanisms that control the generation and loading of these antigens ...
Luc, Van Kaer, Lan, Wu, Sebastian, Joyce
openaire   +2 more sources