Results 51 to 60 of about 18,685 (221)

An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen [PDF]

, 2015
The ability to rapidly secrete cytokines upon stimulation is a functional characteristic of the invariant natural killer T (iNKT) cell lineage. iNKT cells are therefore characterized as an innate T cell population capable of activating and steering ...
Drennan, Michael, Elewaut, Dirk, Govindarajan, Srinath   +2 more
core   +1 more source

Lipid-Reactive T Cells in Immunological Disorders of the Lung

Frontiers in Immunology, 2018
Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders and for host protection from pathogens.
Seungwon Ryu, Seungwon Ryu, Joon Seok Park, Hye Young Kim, Hye Young Kim, Ji Hyung Kim   +5 more
doaj   +1 more source

CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State

Frontiers in Immunology, 2020
The non-polymorphic nature of CD1 proteins creates a situation in which T cells with invariant T cell receptors (TCRs), like CD1d-specific NKT cells, are present in all humans.
Kattya Lopez, Kattya Lopez, Sarah K. Iwany, Sara Suliman, Josephine F. Reijneveld, Josephine F. Reijneveld, Tonatiuh A. Ocampo, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, D. Branch Moody, Ildiko Van Rhijn, Ildiko Van Rhijn   +13 more
doaj   +1 more source

Genetic Regulation of NKT Cell Function [PDF]

, 2017
NKT cells are specialized T cells that play important roles in the host immune response to bacteria and viruses. NKT cells produce a wide variety of cytokines and chemokines after being activated by glycolipids such as α-galactosylceramide (αGalCer ...
Malagic, Murisa
core   +1 more source

Serafino Zappacosta: An Enlightened Mentor and Educator. [PDF]

, 2020
With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science.
Carbone, Ennio, D'Oro, Ugo, De Felice, Mario, Di Rosa, Francesca, Fontana, Silvia, La Cava, Antonio, Maio, Michele, Matarese, Giuseppe, Racioppi, Luigi, Ruggiero, Giuseppina, Terrazzano, Giuseppe   +10 more
core   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

iNKT Cells and Their Potential Lipid Ligands during Viral Infection [PDF]

, 2015
Invariant natural killer T (iNKT) cells are a unique population of lipid-reactive CD1d-restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging ...
Anunya Opasawatchai, Ponpan Matangkasombut   +1 more
core   +1 more source

A Potent CD1d-binding Glycolipid for iNKT-Cell-based Therapy Against Human Breast Cancer [PDF]

, 2019
Background/Aim: Invariant natural killer T-cells (iNKT) stimulated by CD1d-binding glycolipids have been shown to exert antitumor effects by a number of studies in a mouse model.
Brutkiewicz, Randy R., Liu, Jianyun, Seki, Toshiyuki, Tsuji, Moriya   +3 more
core   +1 more source

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring “Universal” Donor T Cells

Frontiers in Immunology, 2020
Chimeric antigen receptor (CAR) engineered T cell therapies individually prepared for each patient with autologous T cells have recently changed clinical practice in the management of B cell malignancies.
Cynthia Perez, Isabelle Gruber, Caroline Arber   +2 more
doaj   +1 more source