Results 71 to 80 of about 11,539 (211)
Linking CD1-Restricted T Cells With Autoimmunity and Dyslipidemia: Lipid Levels Matter
Frontiers in Immunology, 2018 Dyslipidemia, or altered blood lipid content, is a risk factor for developing cardiovascular disease. Furthermore, several autoimmune diseases, including systemic lupus erythematosus, psoriasis, diabetes, and rheumatoid arthritis, are correlated highly ...
Sreya Bagchi +2 more
doaj +1 more source
New Insights Into the Role of Neutrophils in Lymphoma
Cancer Medicine, Volume 15, Issue 6, June 2026.Tissue‐resident neutrophils challenge conventional paradigms by actively infiltrating normal lymphoid organs, predominantly localizing in interstitial compartments, a spatial distribution distinct from their classical vascular positioning. Neutrophils in lymphoid organs exhibit unique phenotypic and functional signatures, suggesting they play roles in ...
Ling Gu
wiley +1 more source
Resilient Biophysical Phenotype of Memory CD4 + T Cells in Long‐Lived Mice
Immunology, Volume 178, Issue 2, Page 363-374, June 2026.Aging is associated with increased stiffness and reduced migratory capacity of memory CD4+ T cells; however, these biophysical declines do not persist in exceptionally long‐lived mice. Instead, long‐lived individuals preserve T cell mechanics, migration and intracellular architecture, supporting mechanical resilience as a hallmark of successful immune ...
Aldo Abarca‐Ortega +6 more
wiley +1 more source
Molecular characterisation of Ovine CD1 [PDF]
, 1994 The CD1 molecules are a family of ß2microglobulin- associated glycoproteins with strong structural homology, but weaker sequence homology, to the MHC class I antigens. In contrast to the classical class I antigens, CD1 molecules exhibit restricted
Ferguson, Elaine Dorothea
core
Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis
Advanced Science, Volume 13, Issue 29, 22 May 2026.This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen +7 more
wiley +1 more source
Frontiers in Immunology, 2018 Mycolic acid (MA), a major lipid component of Mycobacterium tuberculosis (Mtb) cell wall, can be presented by the non-polymorphic antigen presenting molecule CD1b to T cells isolated from Mtb-infected individuals.
Shaobin Shang +11 more
doaj +1 more source
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation
Glia, Volume 74, Issue 5, May 2026.– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond +4 more
wiley +1 more source
Recognition of microbial glycolipids by Natural Killer T cells
Frontiers in Immunology, 2015 T cells can recognize microbial antigens when presented by dedicated antigen-presenting molecules. While peptides are presented by classical members of the Major Histocompatibility (MHC) family (MHC I and II), lipids, glycolipids and lipopeptides can be ...
Dirk Michael Zajonc, Enrico eGirardi
doaj +1 more source
Molecular recognition of microbial lipid-based antigens by T cells [PDF]
, 2018 The immune system has evolved to protect hosts from pathogens. T cells represent a critical component of the immune system by their engagement in host defence mechanisms against microbial infections.
Shahine, Adam +5 more
core +1 more source
Glycolipid targets of Cd1-mediated T-cell responses
, 2001 Members of the CD1 family of antigen-presenting molecules bind and present a variety of mammalian and microbial glycolipids for specific recognition by T cells.
D. Branch Moody +3 more
core +1 more source