Results 91 to 100 of about 11,539 (211)

Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion

Journal of Coloproctology, 2017
Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly in childhood. Ulcerated plaques are one of the cutaneous forms of presentation.
Bruno Lorenzo Scolaro, Gustavo Becker Pereira, Daniel Cury Ogata, Fernanda Souto Padrón Figueiredo Vieira da Cunha, Ana Cristina Martins Effting, Rafael Oselame Guanabara   +5 more
doaj   +1 more source

Structure and functions of microbial lipid antigens presented by CD1

, 2007
The CD1 family of proteins has evolved to bind a range of endogenous and foreign lipids and present these at the cell surface for antigen-specific recognition by T cells.
Willcox, Benjamin, Willcox, Carrie, Dover, Lynn, Besra, Gurdyal; id_orcid   +3 more
core  

CD1 - The pathology perspective [PDF]

, 2001
CD1 molecules are a family of cell surface-associated glycoproteins now recognized as having a role in antigen presentation. These glycoproteins are distinct from yet have some similarities to classical major histocompatibility complex class I and class ...
Rhind, S M ; id_orcid
core   +1 more source

Role of natural killer T lymphocytes during helminthic infection

Parasite, 2008
Natural killer (NK)T cells are innate lymphocytes that release important amount of immunoregulatory cytokines (IFN-γ and/or IL-4) shortly after T cell receptor engagement by (glyco)lipid antigens presented by the CD1d molecules.
Faveeuw C., Mallevaey T., Trottein F.
doaj   +1 more source

Saposins utilize two strategies for lipid transfer and CD1 antigen presentation [PDF]

, 2012
Transferring lipid antigens from membranes into CD1 antigen-presenting proteins represents a major molecular hurdle necessary for T-cell recognition. Saposins facilitate this process, but the mechanisms used are not well understood. We found that saposin
Brenner, Michael B.,, Sun, Ying, Grabowski, Gregory A.,, Peng, Wei,, Besra, Gurdyal S.,, Besra, Gurdyal; id_orcid, Besra, Gurdyal S., Minnaard, Adriaan J.,, Barral, DC, Moody, D. Branch, Tatituri, RVV, Tatituri, Raju V. V., Kasmar, Anne,, Bhowruth, Veemal,, Moody, DB, Bhowruth, Veemal, Brenner, Michael B., Peng, Wei, Peng, W, Kasmar, Anne, Grenha, Rosa,, Sun, Ying,, Grenha, R, Moody, D. Branch,, Leon, L, Tatituri, Raju V.V.,, Veerapen, Natacha,, Grabowski, GA, Leon, Luis, Grabowski, Gregory A., Brenner, MB, Minnaard, Adriaan J., Veerapen, Natacha, Barral, Duarte C., C. Barral, Duarte, Minnaard, AJ, Barral, Duarte C.,, León, Luis,, Kasmar, A, Sun, Y, Minnaard, Adriaan J.; id_orcid, Grenha, Rosa   +41 more
core   +1 more source

Bioinformatic Description of Immunotherapy Targets for Pediatric T-Cell Leukemia and the Impact of Normal Gene Sets Used for Comparison

Frontiers in Oncology, 2014
Pediatric lymphoid leukemia has the highest cure rate of all pediatric malignancies, yet due to its prevalence, still accounts for the majority of childhood cancer deaths and requires long-term highly toxic therapy.
Rimas J Orentas, Jessica eNordlund, Jianbin eHe, Sivasish eSindiri, Crystal eMackall, Terry J Fry, Javed eKhan   +6 more
doaj   +1 more source

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.

, 2006
CD8 T lymphocytes are important effectors in protective immunity against Mycobacterium tuberculosis. We recently characterized the detour pathway of CD8 T cell activation in tuberculosis mediated by apoptotic vesicles from infected cells that transport ...
Hoops, Silvia Locatelli, Subash Sad, Sandhoff, Konrad, de Diego, Juana, Konrad Sandhoff, Bernadette Breiden, Kaufmann, Stefan H. E., Juana de Diego, Winau, Florian, Weber, Stephan, Sad, Subash, Silvia Locatelli Hoops, Kaufmann, Stefan H.E., Kaufmann, Stefan HE, Ulrich E. Schaible, Volker Brinkmann, Florian Winau, Breiden, Bernadette, Brinkmann, Volker, Schaible, Ulrich E, Schaible, Ulrich E., Stephan Weber, Stefan H.E. Kaufmann   +22 more
core   +1 more source

Characterization of a Bovine Thymic Differentiation Antigen Analogous to CD1 in the Human

Scandinavian Journal of Immunology, 1988
Three monoclonal antibodies (MoAb), TH97A, CC13, and CC14, define a thymic differentiation antigen in cattle. The antigen is expressed on 50–60% of bovine thymocytes, located mainly in the cortical areas, but is not expressed on peripheral blood mononuclear cells (PBMC).
MacHugh, Niall D., Bensaid, A.M., Davis, W.C., Howard, C.J., Parsons, K.R., Jones, B., Kaushal, A.   +6 more
openaire   +4 more sources

Emerging roles of CD1 and lipids in human health and disease

Acting alongside MHC proteins, which present peptide antigens, the CD1 system displays lipid antigens to T cells. Recent studies have defined two general mechanisms of T cell receptor (TCR) binding to human CD1a, CD1b, CD1c, and CD1d proteins.
Rossjohn, Jamie, Ogg, Graham S., Moody, D. Branch, de Jong, Annemieke   +3 more
core   +1 more source

No life without death--apoptosis as prerequisite for T cell activation.

, 2005
The orchestrated death of infected cells is key to our understanding of CD8 T cell activation against pathogens. Most intracellular bacteria including Mycobacterium tuberculosis, the etiologic agent of tuberculosis, remain enclosed in phagosomes of ...
Winau, F, Schaible, UE, Hegasy, Guido, Kaufmann, Stefan H. E., Schaible, Ulrich E., Hegasy, G, Winau, Florian, Kaufmann, SHE   +7 more
core   +1 more source