Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention
Cancer Medicine, Volume 15, Issue 2, February 2026.Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa +4 more
wiley +1 more source
Increased expression of two alternative spliced variants of CD1d molecule in human gastric cancer [PDF]
, 2015 Background: CD1d presents glycolipid antigens to invariant natural killer T (iNKT) cells. The role of CD1d in the development of peptic ulcer and gastric cancer has not been revealed, yet.
Ajami, A. +5 more
core
Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]
, 1992 The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Flieger, Dimitri +10 more
core +1 more source
The Journal of Physiology, Volume 604, Issue 4, Page 1708-1735, 15 February 2026.Abstract figure legend The complexation of Moloney murine leukaemia virus (MMLV) with magnetic nanoparticles (MNP) greatly enhanced the transduction of (myo)fibroblasts (FB), when applied in a magnetic field, both in vitro and in vivo in cryoinjured mice.
Timo Mohr +11 more
wiley +1 more source
A virologist’s guide to hide and seek : evasion of innate immunity by primate lentiviruses [PDF]
, 2015 HIV is the cause of a chronic, incurable infection in 37 million people worldwide in 2014. This thesis investigates how the immune system detects HIV and how in turn HIV avoids detection by the immune system.
Bächle, Susanna M
core +1 more source
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion
Journal of Coloproctology, 2017 Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly in childhood. Ulcerated plaques are one of the cutaneous forms of presentation.
Bruno Lorenzo Scolaro +5 more
doaj +1 more source
Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses [PDF]
, 2016 Natural killer T (NKT) cells play a critical role in the host's innate immune response. CD1d-mediated presentation of glycolipid antigens to NKT cells has been established; however, the mechanisms by which NKT cells recognize infected or cancerous cells ...
Bollino, Dominique R. +6 more
core +1 more source
Role of natural killer T lymphocytes during helminthic infection
Parasite, 2008 Natural killer (NK)T cells are innate lymphocytes that release important amount of immunoregulatory cytokines (IFN-γ and/or IL-4) shortly after T cell receptor engagement by (glyco)lipid antigens presented by the CD1d molecules.
Faveeuw C., Mallevaey T., Trottein F.
doaj +1 more source
Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface [PDF]
, 2017 Glycolipid antigens recognized by αβ T-cell receptors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of innate T lymphocytes.
Burdin +12 more
core +2 more sources
Frontiers in Oncology, 2014 Pediatric lymphoid leukemia has the highest cure rate of all pediatric malignancies, yet due to its prevalence, still accounts for the majority of childhood cancer deaths and requires long-term highly toxic therapy.
Rimas J Orentas +6 more
doaj +1 more source