Results 61 to 70 of about 18,685 (221)

Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove [PDF]

, 2005
Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors.
Bjorkman, Pamela J., Dulac, Catherine, Huey-Tubman, Kathryn E., Olson, Rich   +3 more
core   +3 more sources

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Four pathways of CD1 antigen presentation to T cells [PDF]

Current Opinion in Immunology, 2017
CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors. This review discusses the intersection of CD1 trafficking and lipid antigen loading mechanisms in cells, highlighting key ...
D Branch, Moody, Rachel N, Cotton
openaire   +2 more sources

Biological properties of adriamycin bound to biodegradable polymeric carriers [PDF]

, 1993
Three different conjugates having adriamycin (ADR) bound to the side chain carboxyl groups of high-molecular weight poly (¿--glutamic acid) (PGA) either directly or by interpolation of GlyGly and GlyGlyGlyLeu spacers, respectively, were compared with ...
Bhakoo, M., Bouma, J.M.W., Duncan, R., Feijen, Jan, Grootoonk, J., Grootoonk, J., Hoes, C.J.T., Hoes, C.J.T., Hume, I.C.   +8 more
core   +7 more sources

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

, 2008
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains controversial. To address the impact of TLR-mediated pathogen recognition and MyD88-dependent signaling events on anti ...
Abel, Bafica, Blander, Branger, Brightbill, Carroll, Cooper, Drennan, Feng, Flynn, Flynn, Fremond, Fremond, Gilleron, Gutierrez, Han, Holscher, Holscher, Hsieh, Jones, Kamath, Kaufmann, Kaufmann, Kawai, Krieg, MacMicking, MacMicking, Maher, Martinon, Means, Means, Means, Medzhitov, North, Quesniaux, Rausch, Reiling, Ryffel, Scanga, Scanga, Schaible, Seki, Shi, Shi, Shim, Sugawara, Sugawara, Sun, Takeuchi, Thoma-Uszynski, Trinchieri, Underhill, van der Wel, Yates   +53 more
core   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE

Инфекция и иммунитет, 2014
. Besides the multiple hydrolytic enzymes, lysosomes are equipped with proteins apt to activate sphyngo-lipids — saposins (SAP). SAP belong to a broad and diverse family of moderate-size (~80 AA) saposin-like proteins (SAPLIP) containing specific domains
V. V. Yeremeev, A. S. Apt
doaj   +1 more source

Notch signaling during human T cell development [PDF]

, 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy, A Krueger, A Sambandam, A Wilson, A Wolfer, AC Jaleco, AI Garbe, AP Weng, B Blom, B Reizis, B Vandekerckhove, BN Weber, C Benne, CC Tydell, CN Ting, D Hockemeyer, D Hockemeyer, E Robey, EM Six, ES David-Fung, F Klein, F Radtke, F Radtke, F Timmermans, F Weerkamp, F Weerkamp, G Awong, H Hirata, H Neves, H Wang, HT Petrie, HY Kueh, I Hoebeke, I Maillard, I Maillard, I Walle Van de, I Walle Van de, J Buer, J Gotter, J Plum, J Shi, JS Yuan, K Heinzel, K Hozumi, K Li, K Maki, K Tanigaki, L Li, M Ciofani, M Ciofani, M Ciofani, M Garcia-Peydro, M Ghisi, M Magri, M Smedt De, M Smedt De, M Smedt De, M Smedt De, MA Yui, MD Green, ML Joachims, N Lefort, P Beatus, P Doerfler, P Li, QL Hao, QL Hao, R Haddad, RN Motte-Mohs La, S Coppernolle Van, S Doulatov, S Gonzalez-Garcia, S Suliman, S Verbeek, SK Durum, SK Ye, SM Lehar, SY Lee, T Hosoya, T Ikawa, T Ikawa, T Kreslavsky, T Kreslavsky, T Palomero, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, TB Feyerabend, TM Schmitt, TN Taghon, W Dontje, WA Dik, Y Wu, YR Carrasco, Z Galic   +97 more
core   +2 more sources

Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease

Journal of Anatomy, EarlyView.
The fibrocartilage of the murine glenoid fossa and condyle of the temporomandibular joint are shown to form at distinct times with distinct molecular identities. Changes in the condyle during disease lead to remodelling of the fossa to maintain joint alignment.
Ticha Tuwatnawanit, Denisa Belisova, Zuzana Sumbalova Koledova, Neal Anthwal, Abigail S. Tucker   +4 more
wiley   +1 more source

The CD1 size problem: lipid antigens, ligands, and scaffolds [PDF]

Cellular and Molecular Life Sciences, 2014
Whereas research on CD1d has emphasized a few glycosyl ceramides, the broader family of four human CD1 antigen-presenting molecules binds hundreds of distinct self-lipids. Individual lipid types bind within CD1 grooves in different ways, such that they partially fill the groove, match the groove volume, or protrude substantially from the groove.
Dalam, Ly, D Branch, Moody
openaire   +2 more sources