Results 111 to 120 of about 199,281 (229)
Lipid bilayer properties potentially contributed to the evolutionary disappearance of betaine lipids in seed plants. [PDF]
BMC Biol, 2023 Bolik S +7 more
europepmc +1 more source
AlphaFold‐Guided Bespoke Gene Editing Enhances Field‐Grown Soybean Oil Contents
Advanced Science, EarlyView.An AlphaFold‐guided method is developed to functionally optimize soybean sugar transporters and achieve bespoke gene editing of GmSWEET10a/b to improve oil content in an elite soybean cultivar in multi‐year, multi‐site field trials. The combination of AI‐guided protein design and gene editing may unlock a huge potential to improve the genetic trait de ...
Jie Wang +22 more
wiley +1 more source
Micropatterning of functional lipid bilayer assays for quantitative bioanalysis. [PDF]
Biomicrofluidics, 2023 Montalbo RCK, Tu HL.
europepmc +1 more source
Advanced Science, EarlyView.A novel microphysiological system that can mimic sterile or non‐sterile injury demonstrates that macrophage‐derived extracellular vesicles modulate neutrophil migratory responses to these different wound states. The model showed that resolution of inflammation through neutrophil reverse migration is driven by IL‐8 derived from extracellular vesicles ...
Kehinde Adebayo Babatunde +5 more
wiley +1 more source
Publisher Correction: Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases. [PDF]
Nat Rev Mol Cell Biol, 2023 Sakuragi T, Nagata S.
europepmc +1 more source
Advanced Science, EarlyView.PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang +6 more
wiley +1 more source
Advanced Science, EarlyView.The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee +5 more
wiley +1 more source
A quantitative analysis of ligand binding at the protein-lipid bilayer interface. [PDF]
Commun ChemBarkdull AP, Holcomb M, Forli S.
europepmc +1 more source
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases. [PDF]
Nat Rev Mol Cell Biol, 2023 Sakuragi T, Nagata S.
europepmc +1 more source
Advanced Science, EarlyView.This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen +11 more
wiley +1 more source