Results 11 to 20 of about 121,159 (216)
A quantitative analysis of ligand binding at the protein-lipid bilayer interface [PDF]
Communications ChemistryThe majority of drugs target membrane proteins, and many of these proteins contain ligand binding sites embedded within the lipid bilayer. However, targeting these therapeutically relevant sites is hindered by limited characterization of both the sites ...
Allison Pearl Barkdull +2 more
doaj +2 more sources
Functional regulation of aquaporin dynamics by lipid bilayer composition [PDF]
Nature CommunicationsWith the diversity of lipid-protein interactions, any observed membrane protein dynamics or functions directly depend on the lipid bilayer selection.
Anh T. P. Nguyen +2 more
doaj +2 more sources
Biophysica, 2023 The interaction of many peptides with lipid bilayer membranes strongly depends on the lipid composition. Here, a study of the impact of unsaturated lipid acyl chains on the interaction of a derivative of the HIV-1 fusion peptide with lipid bilayer ...
William T. Heller, Piotr A. Zolnierczuk
doaj +1 more source
Water Pores in Planar Lipid Bilayers at Fast and Slow Rise of Transmembrane Voltage
Membranes, 2021 Basic understanding of the barrier properties of biological membranes can be obtained by studying model systems, such as planar lipid bilayers. Here, we study water pores in planar lipid bilayers in the presence of transmembrane voltage.
Alenka Maček Lebar +3 more
doaj +1 more source
Biophysica, 2023 Understanding the membrane interactions of the N-terminal 17 residues of the huntingtin protein (HttN) is essential for unraveling its role in cellular processes and its impact on huntingtin misfolding. In this study, we used atomic force microscopy (AFM)
Yasith Indigahawela Gamage, Jianjun Pan
doaj +1 more source
DNA-nanostructure-templated assembly of planar and curved lipid-bilayer membranes
Frontiers in Chemistry, 2023 Lipid-bilayer nanodiscs and liposomes have been developed to stabilize membrane proteins in order to study their structures and functions. Nanodiscs are detergent-free, water-soluble, and size-controlled planar phospholipid-bilayer platforms.
Mostafa A. Elbahnasawy, Mahmoud L. Nasr
doaj +1 more source
Effect of gold nanoparticle on structure and fluidity of lipid membrane. [PDF]
PLoS ONE, 2014 This paper deals with the effect of different size gold nanoparticles on the fluidity of lipid membrane at different regions of the bilayer. To investigate this, we have considered significantly large bilayer leaflets and incorporated only one ...
Anil R Mhashal, Sudip Roy
doaj +1 more source
Journal of Lipid Research, 2023 Products of lipid peroxidation induce detrimental structural changes in cell membranes, such as the formation of water pores, which occur in the presence of lipids with partially oxidized chains.
Anja Sadžak +6 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2020 Alteration of the lipid composition of biological membranes interferes with their function and can cause tissue damage by triggering apoptosis. Upon lipid bilayer stress, the endoplasmic reticulum mounts a stress response similar to the unfolded protein ...
Richard Venz +3 more
doaj +1 more source
Simulations of Asymmetric Membranes Illustrate Cooperative Leaflet Coupling and Lipid Adaptability
Frontiers in Cell and Developmental Biology, 2020 Biological membranes are composed of lipid bilayers that are often asymmetric with regards to the lipid composition and/or aqueous solvent they separate. Studying lipid asymmetry both experimentally and computationally is challenging.
Madison Blumer +11 more
doaj +1 more source