Results 81 to 90 of about 216,390 (293)

Inclusions induced phase separation in mixed lipid film

, 1999
The effect of rigid inclusions on the phase behavior of a film containing a mixture of lipid molecules is investigated. In the proposed model, the inclusion-induced deformation of the film, and the resulting energy cost are strongly dependent upon the ...
Safran, S., Sens, P.
core   +3 more sources

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

A Simple Computer Model for Liquid Lipid Bilayers

, 2005
We present a simple coarse-grained bead-and-spring model for lipid bilayers. The system has been developed to reproduce the main (gel-liquid) transition of biological membranes on intermediate length scales of a couple of nanometres and is very efficient
Bloom, de Genes, Düchs, Farago, Frenkel, Friederike Schmid, Götz, Heimburg, Huphrey, Mouritsen, Noguchi, Noguchi, Noguchi, Noguchi, Noguchi, Olaf Lenz, Sintes, Sintes, Sintes, Stadler, Standler   +20 more
core   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Viscous regularization and r-adaptive remeshing for finite element analysis of lipid membrane mechanics

, 2007
As two-dimensional fluid shells, lipid bilayer membranes resist bending and stretching but are unable to sustain shear stresses. This property gives membranes the ability to adopt dramatic shape changes. In this paper, a finite element model is developed
Alberts, Ayton, Bacia, Balluffi, Baumgart, Baumgart, Bozic, Božič, Byrd, Canham, Capovilla, Cirak, Cirak, Derényi, Do Carmo, Du, Du, Evans, Evans, Feng, Frey, Fygenson, Gompper, Heinrich, Heinrich, Helfrich, Ho, Hsu, Jaric, Jenkins, Jenkins, Jiang, Jülicher, Jülicher, Kawakatsu, Kraus, Lin Ma, Lipowsky, Nocedal, Noguchi, Noguchi, Powers, Seifert, Seifert, Seifert, Smith, Snapp, Sokolnikoff, Steigmann, Svetina, Svetina, Svetina, Taniguchi, Taniguchi, Toledano, Wang, Wiese, William S. Klug, Wintz, Zhu   +59 more
core   +2 more sources

LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models

Advanced Functional Materials, EarlyView.
This work establishes oligolamellar bacterial membrane models to investigate how LL‐37 disrupts the complex dual‐bilayer architecture of Gram‐negative bacteria. Combining SAXS, cryo‐TEM, electrophoretic mobility measurements, and coarse‐grained simulations, it reveals cardiolipin‐driven phase transitions leading to bicelle‐like structures and membrane ...
Bettina Tran, Diane C.A. Lima, Linda Sandblad, Madeleine Ramstedt, Thereza A. Soares, Stefan Salentinig   +5 more
wiley   +1 more source

Atomistic simulations of a multicomponent asymmetric lipid bilayer

, 2012
The cell membrane is inherently asymmetric and heterogeneous in its composition, a feature that is crucial for its function. Using atomistic molecular dynamics simulations, the physical properties of a 3-component asymmetric mixed lipid bilayer system ...
Polley, Anirban, Rao, Madan, Vemparala, Satyavani   +2 more
core   +1 more source

Lamellar and inverse micellar structures of skin lipids: Effect of templating [PDF]

, 2014
The outermost layer of skin, the stratum corneum (SC), comprises rigid corneocytes in a layered lipid matrix. Using atomistic simulations we find that the equilibrium phase of the SC lipids is inverse micellar.
Das, Chinmay, Noro, Massimo G., Olmsted, Peter D.   +2 more
core   +1 more source

Cholesterol's location in lipid bilayers [PDF]

Chemistry and Physics of Lipids, 2016
It is well known that cholesterol modifies the physical properties of lipid bilayers. For example, the much studied liquid-ordered Lo phase contains rapidly diffusing lipids with their acyl chains in the all trans configuration, similar to gel phase bilayers. Moreover, the Lo phase is commonly associated with cholesterol-enriched lipid rafts, which are
Drew, Marquardt, Norbert, Kučerka, Stephen R, Wassall, Thad A, Harroun, John, Katsaras   +4 more
openaire   +2 more sources

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, EarlyView.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source