Results 151 to 160 of about 107,533 (320)

Phase-separated lipid vesicles: continuum modeling, simulation, and validation [PDF]

arXiv
The paper presents a complete research cycle comprising continuum-based modeling, computational framework development, and validation setup to predict phase separation and surface hydrodynamics in lipid bilayer membranes. We starting with an overview of the key physical characteristics of lipid bilayers, including their composition, mechanical ...
arxiv  

Variational Methods for Biomolecular Modeling

, 2016
Structure, function and dynamics of many biomolecular systems can be characterized by the energetic variational principle and the corresponding systems of partial differential equations (PDEs).
A Ivankin, A Jaramillo, A Warshel, AB Camley, B Lee, B Li, B Li, B Li, B Lu, B Lu, B Wang, BJ Reynwar, BR Brooks, C Mim, D Marsh, D Spoel Van Der, DG Thomas, DL Parton, E Gallicchio, E Gallicchio, EA Evans, F Campelo, FH Stillinger, FM Richards, FS Cohen, G Archontis, G-W Wei, G-W Wei, G-W Wei, GP Leser, GW Wei, HT McMahon, HY Lin, I Massova, I Park, IR Cooke, J Dzubiella, J Faraudo, J Gumbart, J Strain, J Wagoner, J Zimmerberg, JA Grant, JA Grant, JA Grant, JA Wagoner, JC Phillips, JC Stachowiak, JD Madura, JE Rothman, JMJ Swanson, K Farsad, K Lum, K Simons, KA Sharp, KM Callenberg, KS Kim, L-T Gao, LJ Pike, M Daily, M Feig, MD Huang, ME Davis, N Choudhury, N Gavish, NA Baker, NW Schmidt, O Sten-Knudsen, P Concus, P Grochowski, PB Canham, PW Bates, PW Bates, Q Du, Q Du, Q Du, Q Zheng, Q Zheng, R Brewster, R Brewster, R Parthasarathy, RA Pierotti, RE Skyner, RJ Ryham, S Choe, S Dai, S Li, S Osher, S Xu, S Zhao, S Zhao, SC Brenner, T Baumgart, T Kirchhausen, T Simonson, T Sollner, T Takahashi, T Witkowski, T-L Horng, V Luzhkov, VB Chu, W Geng, X Chen, X Chen, Y Tang, Y Wang, Y Wang, Y Wang, Y Zhao, YC Zhou, YC Zhou, Z Chen, Z Chen, Z Chen, ZY Yu   +114 more
core   +1 more source

Interaction of the influenza hemagglutinin fusion peptide with lipid bilayers: area expansion and permeation

Biophysical Journal, 1997
Fusion is a crucial event in the infection of animal cells by enveloped viruses (e.g., HIV or influenza). Viral fusion is mediated by glycoproteins, spanning the viral envelope, which attach to a membrane surface and induce fusion of the viral envelope to the cellular membrane. Influenza fusion protein (hemagglutinin) contains an amino-terminal segment
Alan J. Waring, Marjorie L. Longo, Daniel A. Hammer   +2 more
openaire   +3 more sources

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

The Fusion Activity of IM30 Rings Involves Controlled Unmasking of the Fusogenic Core

Frontiers in Plant Science, 2019
The inner membrane-associated protein of 30 kDa (IM30, also known as Vipp1) is required for thylakoid membrane biogenesis and maintenance in cyanobacteria and chloroplasts.
Adrien Thurotte, Dirk Schneider
doaj   +1 more source

Pressure-dependent adhesion between solid-supported PC-lipid bilayers and vesicles under electric fields [PDF]

arXiv
Fusion of lipid bilayers in membranes is important in processes from vesicle-cell interactions (as in drug delivery) to exosome-cell signaling, while transient transmembrane electric fields are known to occur spontaneously. Two contacting phosphatidylcholine (PC) lipid membranes are known to fuse into one under external electric fields, suggesting that
arxiv  

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Taxonomy of Chemical Bondings: Opportunities and Challenges

Angewandte Chemie, EarlyView.
The recent focus on supramolecular and nanosized systems produced a major increase in the types of observed noncovalent interactions and in the diversity of terms used to designate them. A hierarchical categorization (taxonomy) of terms used to designate electrophile···nucleophile interactions is proposed here.
Andrea Pizzi, Giancarlo Terraneo, Cristina Lo Iacono, Roberta Beccaria, Arun Dhaka, Giuseppe Resnati   +5 more
wiley   +2 more sources

Water-phospholipid interactions at the interface of lipid membranes: comparison of different force fields [PDF]

arXiv, 2016
Water-phospholipid interactions at the lipid bilayer/water interfaces are of essential importance for the dynamics, stability and function of biological membrane, and are also strongly associated with numerous biological processes at the interfaces of lipid bilayers.
arxiv  

Development and Application of Organic Sonosensitizers in Cancer Therapy

Aggregate, EarlyView.
This review provides a comprehensive overview of organic sonosensitizers employed in cancer treatment, describing their underlying mechanisms and structure‐activity relationship in terms of sonodynamic therapy. The significance of nanotechnology and combination therapy with other oncological modalities (photothermal therapy, photodynamic therapy, etc.)
Yuhan Ding, Yuchen Yang, Omer Aras, Feifei An, Mengjiao Zhou, Yichao Chai   +5 more
wiley   +1 more source