Results 171 to 180 of about 107,533 (320)

From biological membranes to biomimetic model membranes [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2010
Biological membranes play an essential role in the cellular protection as well as in the control and the transport of nutrients. Many mechanisms such as molecular recognition, enzymatic catalysis, cellular adhesion and membrane fusion take place into the
Eeman, M., Deleu, M.
doaj  

SMARTINI3: Systematic Parametrization of Realistic Multi-Scale Membrane Models via Unsupervised Learning and Multi-Objective Evolutionary Algorithms [PDF]

arXiv
In this study, we utilize genetic algorithms to develop a realistic implicit solvent ultra-coarse-grained (PC) membrane model comprising only three interaction sites. The key philosophy of the ultra-CG membrane model SMARTINI3 is its compatibility with realistic membrane proteins, for example, modeled within the Martini coarse-grained (CG) model, as ...
arxiv  

Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation. [PDF]

, 2018
Interactions between EphB4 receptor tyrosine kinases and their membrane-bound ephrin-B2 ligands on apposed cells play a regulatory role in neural stem cell differentiation.
Chung, Jean, Dong, Meimei, Groves, Jay, Lee, Young, SCHAFFER, David, Spelke, Dawn, Yu, Cheng-Han   +6 more
core  

Label‐Free Detection of Virus‐Membrane Interactions Using Surface‐Enhanced Infrared Absorption (SEIRA) Spectroscopy

Angewandte Chemie International Edition, EarlyView.
Viral binding and fusion are early steps during viral infection. Surface‐enhanced infrared absorption spectroscopy enables the label‐free tracking of molecular events, as the influenza A virus interacts with a host cell model membrane, providing chemical resolution for viral proteins, viral lipids, and host lipids.
Amelie Teresa Heinen, Saskia Heermant, Daniel Christian Lauster, Stephan Block, Jacek Kozuch   +4 more
wiley   +1 more source

Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE

Cell Reports, 2019
Summary: Intracellular vesicle fusion is mediated by soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins. It is generally accepted that membrane fusion occurs when the vesicle and target membranes
Shailendra S. Rathore, Yinghui Liu, Haijia Yu, Chun Wan, MyeongSeon Lee, Qian Yin, Michael H.B. Stowell, Jingshi Shen   +7 more
doaj  

Flexible String Model of Unsaturated Lipid Bilayer [PDF]

arXiv
An analytically solvable model of unsaturated lipid bilayer is derived by introducing finite bending angle of the unsaturated bond relative to straight part of the lipid chain considered previously in our model of semi-flexible strings. It is found that lateral pressure profile of unsaturated lipids has distinct maximum in the unsaturated bond region ...
arxiv  

Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups

Angewandte Chemie International Edition, Accepted Article.
Protein‐based tools are emerging as innovative solutions to interfere with biological pathways in molecular biology and medicine. They offer advantages over traditional small molecules due to their adaptable structural diversity and their ability to engage previously inaccessible cellular targets.
Jonathan Franke, Jan Vincent V. Arafiles, Leis Christian, Christian Hackenberger   +3 more
wiley   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio
Neurotransmitter release is triggered in microseconds by the two C2 domains of the Ca2+ sensor synaptotagmin‐1 and by SNARE complexes, which form four‐helix bundles that bridge the vesicle and plasma membranes. The synaptotagmin‐1 C2B domain binds to the
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
doaj   +1 more source

Non‐Amphiphilic Antimicrobial Polymers

Angewandte Chemie International Edition, Accepted Article.
Antimicrobial resistance (AMR) is a severe threat to modern health care and must be addressed to prevent millions of deaths in the coming decades. Antimicrobial polymers (APs) do not provoke resistances and are promising alternatives to conventional antibiotics. Classic APs possess an amphiphilic structure (cationic and hydrophobic). Herein we question
Alain M. Bapolisi, Anne-Catherine Lehnen, Martin Wolff, Jana Kramer, Sergio Kogikoski, René Steinbrecher, Nicole Michler, Andreas Kiesow, Ilko Bald, Martina Obry, Sebastian Kersting, Till Stensitzki, Henrike M. Müller-Werkmeister, Meike N. Leiske, Salvatore Chiantia, Matthias Hartlieb   +15 more
wiley   +1 more source

Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

BMEMat, EarlyView.
This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical ...
Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan   +6 more
wiley   +1 more source