Results 251 to 260 of about 107,533 (320)

LL‐37 Inhibits TMPRSS2‐Mediated S2' Site Cleavage and SARS‐CoV‐2 Infection but Not Omicron Variants

Cell Proliferation, EarlyView.
Cathelicidin LL‐37 inhibits SARS‐CoV‐2 by blocking the catalytic activity of TMPRSS2. The N764K mutation in the spike S2 subunit of Omicron variants confers resistance to LL‐37‐induced inhibition of TMPRSS2‐mediated S2' priming. ABSTRACT Continual evolution of SARS‐CoV‐2 spike drives the emergence of Omicron variants that show increased spreading and ...
Zhenfei Bi, Wenyan Ren, Hao Zeng, Yuanyuan Zhou, Jian Liu, Zimin Chen, Xindan Zhang, Xuemei He, Guangwen Lu, Yuquan Wei, Xiawei Wei   +10 more
wiley   +1 more source

Leaflet-Specific Structure and Dynamics of Solid and Polymer Supported Lipid Bilayers. [PDF]

Angew Chem Int Ed Engl
Karedla N, Schneider F, Enderlein J, Chen T.   +3 more
europepmc   +1 more source

Membrane selectivity and pore formation of SprA1 and SprA2 hemolytic peptides from Staphylococcus aureus type I toxin–antitoxin systems

The FEBS Journal, EarlyView.
When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon, Noëlla Germain‐Amiot, Charlotte Oriol, Astrid Rouillon, Yoann Augagneur, Stéphane Dréano, Irène Nicolas, Alexandre Chenal, Arnaud Bondon, Soizic Chevance, Marie‐Laure Pinel‐Marie   +10 more
wiley   +1 more source

Functionally distinct SNARE motifs of SNAP25 cooperate in SNARE assembly and membrane fusion. [PDF]

Biophys J
Kraichely KN, Sandall CR, Liang B, Kiessling V, Tamm LK.   +4 more
europepmc   +1 more source

A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel

The FEBS Journal, EarlyView.
A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang, Noah J. Levi, Maykelis Diaz‐Solares, Carsten Mim, Gerhard Dahl, Rene Barro‐Soria   +5 more
wiley   +1 more source

Potency of agarose gel‐supported lipid bilayers for electrophysiologic analysis of channel pores formed by Bacillus thuringiensis insecticidal proteins

The FEBS Journal, EarlyView.
Agarose gel‐supported lipid bilayers constructed at the interface between the lipid solution and the recording solution are useful for measuring channel currents through different types of toxin pores. In this system, the lipid bilayers can be easily reconstructed even after the bilayer is disrupted, and measurements of toxin pores could be repeated ...
Tsubasa Okuda, Tomoya Takeuchi, Mami Asakura, Minako Hirano, Toru Ide, Tohru Hayakawa   +5 more
wiley   +1 more source

Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy. [PDF]

Nat Commun
Zhang Q, Rosa RSL, Ray A, Durlet K, Dorrazehi GM, Bernardi RC, Alsteens D.   +6 more
europepmc   +1 more source

Natural aminosterols inhibit NMDA receptors with low nanomolar potency

The FEBS Journal, EarlyView.
Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani, Elisabetta Coppi, Silvia Errico, Federica Cherchi, Martina Gennari, Denise Barbut, Michele Vendruscolo, Michael Zasloff, Anna Maria Pugliese, Fabrizio Chiti   +9 more
wiley   +1 more source

Local Stress in Cylindrically Curved Lipid Membrane: Insights into Local Versus Global Lateral Fluidity Models. [PDF]

Biomolecules
Pinigin KV.
europepmc   +1 more source

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

The FEBS Journal, EarlyView.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie, Rebecca Rowan, Dessi Malinova, Lisa Crawford   +3 more
wiley   +1 more source