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Non-bilayer lipids and biological fusion intermediates

Chemistry and Physics of Lipids, 1996
Disparate biological fusion reactions and fusion of purely lipid bilayers are similarly influenced by 'non-bilayer' lipids (lipids which do not form lipid bilayers in water by themselves). Lipid composition of membranes affects biological fusion at a stage downstream of activation of fusion proteins and prior to fusion pore formation.
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Reaction characteristics and mechanisms of lipid bilayer vesicle fusion

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1984
Abstract Small unilamellar lipid bilayer vesicles were prepared from brain phosphatidylserine, egg phosphatidylcholine, and synthetic dipalmitoylphosphatidylcholine, and were fused into larger structures by freezing and thawing, addition of calcium chloride, and passage through the lipid phase transition temperature.
Suzanne M. Gibson, George Strauss
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Studying membrane fusion using supported lipid bilayers on superparamagnetic beads

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2023
The fusion between two lipid membranes is a ubiquitous mechanism in cell traffic and pathogens invasion. Yet it is not well understood how two distinct bilayers overcome the energy barriers towards fusion and reorganize themselves to form a unique continuous bilayer.
Letrou, Mathieu   +3 more
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Mimicking Influenza Virus Fusion Using Supported Lipid Bilayers

Langmuir, 2014
Influenza virus infection is a serious public health problem in the world, and understanding the molecular mechanisms involved in viral replication is crucial. In this paper, we used a minimalist approach based on a lipid bilayer supported on mica, which we imaged by atomic force microscopy (AFM) in a physiological buffer, to analyze the different ...
Cédric Godefroy   +10 more
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Fusion of lipid bilayers induced by synthetic lipids and peptides

1996
The fusion-inducing properties of three different synthetic lipid derivatives were investigated in model membranes. The results are discussed in terms of membrane destabilization caused by the formation of non-bilayer lipid structures following charge neutralization of the fusogenic components. First, studies on the fusion of large unilamellar vesicles
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Serotonin Promotes Vesicular Association and Fusion by Modifying Lipid Bilayers

The Journal of Physical Chemistry B
AbstractThe primary event in chemical neurotransmission involves the fusion of a membrane-limited vesicle at the plasma membrane and the subsequent release of its chemical neurotransmitter cargo. The cargo itself is not known to have any effect on the fusion event. However, amphiphilic monoamine neurotransmitters (e.g. serotonin and dopamine) are known
Debsankar Saha Roy   +5 more
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Target-selective vesicle fusion induced by molecular recognition on lipid bilayers

Chem. Commun., 2009
A novel programmable membrane fusion system driven by selective molecular recognition between diols and boronic acids on the different vesicles was constructed in this study.
Mana Tsuboi   +2 more
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Spontaneous Membrane Fusion Induced by Chemical Formation of Ceramides in a Lipid Bilayer

Journal of the American Chemical Society, 2006
Mere chemical generation of ceramide and related double-chain lipids in the membrane of small unilamellar vesicles (SUVs) induces fusion of the vesicles. The lipids can be successfully prepared by dehydrocondensation between single-chain lipids (fatty acids and sphingosine or its analogues) in a lipid bilayer of the SUV by using a combination of 2 ...
Kazuhito Hioki   +6 more
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Fusion of Ligand-Coated Nanoparticles with Lipid Bilayers: Effect of Ligand Flexibility

The Journal of Physical Chemistry A, 2014
Amphiphilic, monolayer-protected gold nanoparticles (AuNPs) have recently been shown to insert into and fuse with lipid bilayers, driven by the hydrophobic effect. The inserted transmembrane state is stabilized by the "snorkeling" of charged ligand end groups out of the bilayer interior.
Reid C. Van Lehn, Alfredo Alexander-Katz
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