Results 181 to 190 of about 2,675,614 (299)

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling. [PDF]

Nat Aging
Moral-Sanz J, Fernández-Carrasco I, Ramponi V, Garrido A, Karbat I, Cabezas-Sainz P, Rivera-de-Torre E, Elsallabi O, Martín-Hernández R, López-Aceituno JL, Price NL, Sanchez L, Colmenarejo G, Martínez-Del-Pozo Á, Vetter I, Cogolludo A, Perez-Vizcaino F, Del-Pozo J, Reuveny E, Fernández-Rojo MA, Robbins PD, de Cabo R, Serrano M, Ikonomopoulou MP.   +23 more
europepmc   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

A pathogenic mutation in α-SNAP impairs membrane lipid binding by concealing a critical hydrophobic loop. [PDF]

Commun Biol
Méndez-Ruette M, Bedoya M, Hinrichsen B, Henzi R, Muñoz-Gutiérrez C, Parga C, Muñoz C, Márquez G, Muñoz RI, Sandoval S, Ross BH, Vivar JP, Mardones GA, Brauchi S, Wyneken Ú, Michaut MA, González W, Bátiz LF.   +17 more
europepmc   +1 more source

Computational model for lipid binding regions in phospholipase (Ves a 1) from Vespa venom. [PDF]

Sci Rep, 2023
Pattaranggoon NC, Daduang S, Rungrotmongkol T, Teajaroen W, Tipmanee V, Hannongbua S.   +5 more
europepmc   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

SigmaR1 is an auxiliary translocon factor with lipid-binding activity that regulates protein and lipid droplet homeostasis. [PDF]

Nat Commun
Hu X, Zhou T, Cui T, Du Y, Song C, Chang W, Xiong J, Qin J, Deng L, Ji WK.   +9 more
europepmc   +1 more source

Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition. [PDF]

Drug Metab Dispos, 2023
Yabut KCB, Isoherranen N.
europepmc   +1 more source

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source

Structural and functional insights into calmodulin-mediated lipid binding and proteolytic cleavage of the M-PMV matrix protein. [PDF]

J Biol Chem
Buresova K, Nesporova T, Prchal J, Banerjee S, Castoralova M, Hodbodova L, Kukacka Z, Junkova P, Ruml T.   +8 more
europepmc   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source