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Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
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Leveraging the Fragment Molecular Orbital and MM-GBSA Methods in Virtual Screening for the Discovery of Novel Non-Covalent Inhibitors Targeting the TEAD Lipid Binding Pocket. [PDF]
Int J Mol SciKim J +7 more
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2023
The Src homology 2 (SH2) domain is a modular protein interaction domain that specifically recognizes the phosphotyrosine (pY) motif of a target molecule. We recently reported that a large majority of human SH2 domains tightly bind membrane lipids, and many show high lipid specificity.
Wonhwa, Cho +2 more
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The Src homology 2 (SH2) domain is a modular protein interaction domain that specifically recognizes the phosphotyrosine (pY) motif of a target molecule. We recently reported that a large majority of human SH2 domains tightly bind membrane lipids, and many show high lipid specificity.
Wonhwa, Cho +2 more
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The lipid-binding SEC14 domain
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007Protein-lipid interactions are important for protein targeting, signal transduction, lipid transport, lipid biosynthesis, lipid metabolism, and the maintenance of cellular compartments and membranes. Specific lipid-binding protein domains, such as PH, FYVE, PX, PHD, C2 and SEC14 homology domains, mediate interactions between proteins and specific ...
Kan, Saito, Lutz, Tautz, Tomas, Mustelin
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Science's STKE, 2000
Signals can be regulated by many flexible strategies, including blocking protein catalytic activity, reducing product accumulation, or sequestrating proteins from their site of action. Several protein binding domains that regulate the interaction of proteins with each other have been identified.
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Signals can be regulated by many flexible strategies, including blocking protein catalytic activity, reducing product accumulation, or sequestrating proteins from their site of action. Several protein binding domains that regulate the interaction of proteins with each other have been identified.
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Identification of Lipid-Binding Effectors
2011In recent years, the functional roles of effectors from a wide variety of fungal and oomycete pathogens have begun to emerge. As a product of this work, the importance of effector-lipid interactions has been made apparent. Phospholipids are not only important signaling molecules, but they also play important roles in the trafficking of endosomes and ...
Shiv D, Kale, Brett M, Tyler
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Assembly and characterization of lipid–lipid binding protein particles
Journal of Biotechnology, 2011Lipid-protein complexes, lipoplexes, are currently of great interest because of their immunogenic, gene free, and low cost properties. For their applications as potential vaccines, it is critical to display a target protein on the surface of lipoplex particles to allow external interactions to take place. However, how to effectively assemble lipoplexes
Wei, Huang, Chenming, Zhang
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Lipid Mobility and Molecular Binding in Fluid Lipid Membranes
Journal of the American Chemical Society, 2005The lateral mobility of dilute concentrations of fluorescently labeled lipids doped into supported membranes is found to change upon receptor ligand binding at the membrane surface, even when the lipid is not directly involved in the binding event.
Victoria, Yamazaki +3 more
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Actin binding proteins — lipid interactions
Journal of Muscle Research and Cell Motility, 1991Publisher Summary The actin-binding proteins–lipid interactions at the plasma membrane interface are considered via two aspects: first, generation of intracellular signals or second messengers—besides the classical receptor pathway—may involve mechanical stimuli that are produced by applying physical forces to the cell surface.
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