Results 251 to 260 of about 511,973 (318)

Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines. [PDF]

NPJ Vaccines
Danz H, Dauner A, Sharma S, Babiceanu M, Clark N, Ontiveros RJ, Amezquita R, Zhilin-Roth A, Reyes E, Khoo C, Gilbert K, Nadkarni J, Chaudhary O, Lee C, Kume A, Bahadoran A, Motwani M, Lu B, Zong W, Kettring A, Shumate A, Karve S, Dias A, Wu M, Gu X, Yan Y, Anderson DG, Schanen B, Chivukula S, DeRosa F.   +29 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Zanthoxylum bungeanum leaf enhanced yolk color and egg flavor in laying hens by altering yolk lipid composition. [PDF]

Poult Sci
Cao S, Lin H, Li X, Zhao J, Lei Q, Zhou J, Wang J, Liu J.   +7 more
europepmc   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Lipidomics Reveals Differences in Lipid Composition Between Lipid Droplets and Milk Fat Globules in Dairy Goat Mammary Tissue. [PDF]

Animals (Basel)
Wu K, Yang J, Yang Y, Wang H, Fan Y, Yang Y, Liu Y, Han L.   +7 more
europepmc   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Lipid Composition of Nanocarriers Shapes Interactions of Cyclic Antimicrobial Peptide Gramicidin S with Their Membranes. [PDF]

Int J Mol Sci
Berest V, Sichevska L, Gorobchenko O, Perepelytsia I, Bozhok G, Skorokhod O.   +5 more
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Changes in Metabolism and Lipid Composition with Nitrogen Starvation and Recovery in a New Productive Strain of <i>Neochlorella semenenkoi</i> Using N¹⁵-Isotopic Labeling and HRMS. [PDF]

Int J Mol Sci
Vishnevskaya A, Bashilov A, Senko D, Osipenko S, Sinetova M, Malyshev N, Khaitovich P, Nikolaev E, Kostyukevich Y.   +8 more
europepmc   +1 more source