Results 151 to 160 of about 870,619 (302)

Droplet networks, from lipid bilayers to synthetic tissues

, 2019
An aqueous droplet in a solution of lipid in oil acquires a lipid monolayer coat. When two such droplets are brought together, they adhere through the formation of a droplet interface bilayer (DIB) (Fig. 1a).
Florence G. Downs, Vanessa Restrepo Schild, Michael J. Booth, Hagan Bayley   +3 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

C18ORF32 modulates lipid droplet secretion via secretory autophagy and restrains hepatic steatosis in vivo

Cell Communication and Signaling
Background Lipid droplets (LDs) are essential for maintaining cellular homeostasis by storing excess lipids, but regulation of their cellular level is crucial to prevent lipotoxicity under normal conditions.
Abhishek Kumar, Shailesh Kumar Gupta, Yogendra Pratap Mathuria, Debasish Kumar Ghosh   +3 more
doaj   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation

, 2013
Comparative actions of omega-3 fatty acids on in-vitro lipid droplet ...
David Cameron-Smith (13049868), Andrew Sinclair (13058406), E Barber (11057472)   +2 more
core  

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Opn3 Drives Blue-Light-Induced Reduction in Lipid Droplets and Antiviral Defense

Biomolecules
Abnormal lipid metabolism is a key feature of many diseases. Therefore, investigating its underlying mechanisms is of great importance. Recently, blue light has shown promise as a drug-free way to influence energy metabolism, relying on the light ...
Qifan Wu, Huiping Liu, Hongcui Liang, Xinyi Jiang, Yingqiao Qin, Shaomei Liang, Jingjing Wang, Kunpeng Liu   +7 more
doaj   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Lipid Droplet Surface Promotes 3D Morphological Evolution of Non‐Rhomboidal Cholesterol Crystals

Advanced Science
Cholesterol crystals, which cause inflammation and various diseases, predominantly grow in a platy, rhomboid structure on the plasma membranes but exhibit an uneven three‐dimensional (3D) architecture intracellularly.
Hyun‐Ro Lee, Seunghan Kang, Siyoung Q. Choi   +2 more
doaj   +1 more source

Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth

Abstract Caveolae are 50-100 nm sized plasma membrane invaginations involved in cellular lipid uptake and lipid accumulation. Several caveolin1 and cavin1 mutations are associated to human lipodystrophy. Interestingly, previous research identified caveolae proteins at lipid droplets although their specific cellular function at lipid ...
Esther Ocket, Tamara Pietrucik, Luis Wong-Dilworth, Michaela Rath, Daniel Aik, Dmytro Puchkov, Max Ruwolt, Martin Lehmann, Claudia Matthaeus   +8 more
openaire   +1 more source