Results 141 to 150 of about 1,446,619 (399)

Implications of lipid droplets in lung cancer: Associations with drug resistance

Oncology Letters, 2020
Cancer cells usually show different metabolic patterns compared with healthy cells due to the reprogramming of metabolic processes. The process of lipid metabolism undergoes notable changes, leading to the accumulation of lipid droplets in cells ...
Chun-mei Jin, P. Yuan
semanticscholar   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]

, 2019
Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni, Bianchi, Michele Maria, Cirigliano, Angela, Macone, Alberto, Negri, Rodolfo, Oliaro-Bosso, Simonetta, Rinaldi, Teresa   +6 more
core   +2 more sources

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

Nature Communications, 2019
The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here we show that nuclear LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs, a precursor to very low-density lipoproprotein (VLDL ...
Kamil Sołtysik, Y. Ohsaki, Tsuyako Tatematsu, Jinglei Cheng, T. Fujimoto   +4 more
semanticscholar   +1 more source

Clinical Outcomes of Patients Within the Rheumatoid Arthritis Care Pathway Cohort at a Tertiary Care Integrated Delivery Network: A Comparison to Usual Care

Arthritis Care &Research, EarlyView.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

The hypoxic transcription factor KlMga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis [PDF]

, 2019
Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes.
Bianchi, Michele M, Brambilla, Luca, Camponeschi, Ilaria, Immesi, Alessio, Mazzoni, Cristina, Polo, Germano, Rinaldi, Teresa, Santomartino, Rosa   +7 more
core   +1 more source

Lipid droplets disrupt mechanosensing in human hepatocytes

bioRxiv, 2020
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death in the world. Although most cases occur in stiff, cirrhotic livers, and stiffness is a significant risk factor, HCC can also arise in non-cirrhotic livers in the setting of non ...
Likang Chin, N. Theise, Abigail E. Loneker, P. Janmey, R. Wells   +4 more
semanticscholar   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS

European Journal of Histochemistry
Lipid droplets (LDs) are present in the nucleus, though much less abundant than cytoplasmic LDs. We investigated nuclear LDs generated in amino acid-deprived conditions, and found that diacylglycerol (DAG), produced by ATGL-mediated hydrolysis of ...
doaj   +1 more source

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic1,s⃞

Journal of Lipid Research, 2007
Lipid droplets are accumulations of neutral lipids surrounded by a monolayer of phospholipids and associated proteins. Recent proteomic analysis of isolated droplets suggests that they are part of a dynamic organelle system that is involved in membrane ...
René Bartz, Wen-Hong Li, Barney Venables, John K. Zehmer, Mary R. Roth, Ruth Welti, Richard G.W. Anderson, Pingsheng Liu, Kent D. Chapman   +8 more
doaj   +1 more source