Results 171 to 180 of about 863,741 (256)

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Tripartite ER-mitochondria-lipid droplets contact sites control adipocyte metabolic flexibility. [PDF]

EMBO J
Palard M, Chadeuf G, Carpentier M, Renaud CCN, Frey S, Croyal M, Shaaban R, Hadjadj S, Cloteau C, El Khallouki N, Bomme P, Le Lay S, Majrouh M, Paul-Gilloteaux P, Humbert A, Durand C, Bertocchini N, Dubreil L, Combot Y, Antreou A, Le May C, Ducheix S, Cariou B, Giordano F, Rieusset J, Thiam AR, Prieur X.   +26 more
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

An optimized method to visualize lipid droplets in mouse brain tissue. [PDF]

Cell Rep Methods
Rey A, Petrelli F, Panfilova D, Madsen S, Héritier N, Knobloch M.   +5 more
europepmc   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

The interplay of lipid droplets, mitochondria, and ER in governing hepatic lipid metabolism. [PDF]

Curr Opin Cell Biol
Hofstadter WA, Reid MV, Mashek DG.
europepmc   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets. [PDF]

EMBO J
Acin-Perez R, Assali EA, Veliova M, Ngo J, Brownstein AJ, Villalobos F, Petcherski A, Hernansanz-Agustin P, Kim-Vasquez D, Xu S, Tamboline M, Silva RM, Upcher A, Shu C, Ferriss DE, Liesa M, Enriquez JA, Sekler I, Shirihai OS.   +18 more
europepmc   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Solvatochromic diacylglycerol-mimetic probes reveal distinct trafficking of DAG-like lipids to lipid droplets. [PDF]

Bioorg Chem
Gomez C, McInchak N, Louis S, Heck E, Mesa H, Meade J, Zhang Q, Stawikowski MJ.   +7 more
europepmc   +1 more source