Results 231 to 240 of about 174,447 (304)

Protocol for isolation of lipid droplets and mitochondria from acute myeloid leukemia cells for lipidomic analysis. [PDF]

STAR Protoc
Zhao R, Zhang L, Dong S, Kamachi K, Gupta SK, Akiyama H, Nguyen J, Hackman GL, Andreeff M, Lodi A, Ishizawa J.   +10 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Selective Targeting of Kinesin on Lipid Droplets in the Liver Reduces Serum Lipids

Tripathy S, Mahapatra A, Saharan O, Chatterjee H, Sengupta N, Kamat S, Nair S, Mallik R.   +7 more
europepmc   +1 more source

Lipid droplets in plants: turnover and stress responses. [PDF]

Front Plant Sci
Zhao Y, Cao R, Li J, Xu Y, Zhou L, Ye Y.
europepmc   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation. [PDF]

Adv Sci (Weinh)
Jia J, Gan Y, Li J, Li L, Meng H, Sun M, Ye L, Mao R, Cao X, Xia S, Bao X, Liu R, Zhang M, Xu Y.   +13 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Si-Ni-San improves the deposition of lipid droplets in MAFLD through modulating the FXR-GPAT4 axis. [PDF]

Chin Med
Fan H, Hou Y, Li Y, Zheng Z, Wang X, Li Y, Li Y.   +6 more
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Focus on the role of mixed micelles and lipid droplets in the oxidative stability of oil-in-water emulsions using size distribution Taylor dispersion analysis. [PDF]

Curr Res Food Sci
Durand E, Troncho T, Koli H, Robichon C, Villeneuve P.   +4 more
europepmc   +1 more source