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The New Face of the Lipid Droplet: Lipid Droplet Proteins
PROTEOMICS, 2018AbstractThe lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD proteomic research has provided fundamentally important insights into this organelle's functions. The review provides a summary of LD proteomic studies conducted across diverse organisms and cell and tissue types.
Congyan, Zhang, Pingsheng, Liu
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Phospholipids and lipid droplets
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013Lipid droplets are ubiquitous cellular organelles that allow cells to store large amounts of neutral lipids for membrane synthesis and energy supply in times of starvation. Compared to other cellular organelles, lipid droplets are structurally unique as they are made of a hydrophobic core of neutral lipids and are separated to the cytosol only by a ...
Anke, Penno +2 more
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Lipid Structure in Triolein Lipid Droplets
The Journal of Physical Chemistry B, 2014Lipid droplets (LDs) are primary repositories of esterified fatty acids and sterols in animal cells. These organelles originate on the lumenal or cytoplasmic side of endoplasmic reticulum (ER) membrane and are released to the cytosol. In contrast to other intracellular organelles, LDs are composed of a mass of hydrophobic lipid esters coved by ...
Chaban, Vitaly V +1 more
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Lipid Droplets and Neurodegeneration
NeuroscienceEnergy metabolism in the brain has been considered one of the critical research areas of neuroscience for ages. One of the most vital parts of brain metabolism cascades is lipid metabolism, and fatty acid plays a crucial role in this process. The fatty acid breakdown process in mitochondria undergoes through a conserved pathway known as β-oxidation ...
Keya Mallick +3 more
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Distribution of Neutral Lipids in the Lipid Droplet Core
The Journal of Physical Chemistry B, 2014Cholesteryl esters (CEs) are a form of cholesterol (CHOL) storage in the living cells, as opposed to free CHOL. CEs are major constituents of low density lipoprotein particles. Therefore, CEs are implicated in provoking atherosclerosis. Arranged into cytoplasmic lipid droplets (LDs), CEs are stored intracellularly.
Chaban, Vitaly V, Khandelia, Himanshu
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DFCP1 associates with lipid droplets
Cell Biology International, 2019AbstractDouble FYVE‐containing protein 1 (DFCP1) is ubiquitously expressed, participates in intracellular membrane trafficking and labels omegasomes through specific interactions with phosphatidylinositol‐3‐phosphate (PI3P). Previous studies showed that subcellular DFCP1 proteins display multi‐organelle localization, including in the endoplasmic ...
Guangang, Gao +4 more
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Analysis of Biogenesis of Lipid Droplets by Examining Rab40c Associating with Lipid Droplets
2014The biogenesis of lipid droplets (LDs) is regulated by multiple proteins. Rab40c is a recently characterized small GTPase associating with LDs. Here we describe our approaches to analyze the involvement of Rab40c in the biogenesis of LDs. Co-localization of Rab40c and LDs was revealed through fluorescence confocal microscopy by expressing GFP-Rab40c ...
Ran, Tan +3 more
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Mechanisms of lipid droplet biogenesis
Biochemical Journal, 2019Abstract Lipid droplets (LDs) are organelles that compartmentalize nonbilayer-forming lipids in the aqueous cytoplasm of cells. They are ubiquitous in most organisms, including in animals, protists, plants and microorganisms. In eukaryotes, LDs are believed to be derived by a budding and scission process from the surface of the ...
Kent D. Chapman +3 more
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Lipid droplets in inflammation and cancer
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2010Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes, epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed phenotype in infectious, neoplastic and other inflammatory conditions. Lipid droplet biogenesis is a regulated cellular process that culminates in the compartmentalization of ...
Patricia T, Bozza, João P B, Viola
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Microscopy, 2011
The lipid droplet (LD), an organelle that exists ubiquitously in various organisms, from bacteria to mammals, has attracted much attention from both medical and cell biology fields. The LD in white adipocytes is often treated as the prototype LD, but is rather a special example, considering that its size, intracellular localization and molecular ...
Michitaka, Suzuki +3 more
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The lipid droplet (LD), an organelle that exists ubiquitously in various organisms, from bacteria to mammals, has attracted much attention from both medical and cell biology fields. The LD in white adipocytes is often treated as the prototype LD, but is rather a special example, considering that its size, intracellular localization and molecular ...
Michitaka, Suzuki +3 more
openaire +2 more sources