Results 291 to 300 of about 1,446,619 (399)

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion.

Cell Metabolism, 2018
Ilan Y. Benador, Michaela Veliova, Kiana Mahdaviani, A. Petcherski, J. Wikstrom, Essam A. Assali, R. Acín-Pérez, Michael Shum, Marcus F. Oliveira, S. Cinti, C. Sztalryd, William D. Barshop, J. Wohlschlegel, B. Corkey, M. Liesa, O. Shirihai   +15 more
semanticscholar   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Extracellular Vesicles, Lipid Droplets and AhR Ligands in Early Implantation: The Dynamics of Embryo-Maternal Crosstalk. [PDF]

J Extracell Vesicles
Komsky-Elbaz A, Shuhmaher M, Sanchez-Lopez JA, Teena O, Waiger D, Zelinger E, Kossovsky T, Otikovs L, Dilevsky E, Soen Y, Hefetz A, Heifetz Y.   +11 more
europepmc   +1 more source

Lipid droplets: a candidate new research field for epithelial ovarian cancer [PDF]

Shiro Koizume, Tomoko Takahashi, Yohei Miyagi   +2 more
openalex   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia. [PDF]

Nature
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Byeon SK, Thapa C, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Schneider JA, Pandey A, Bennett DA, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J.   +20 more
europepmc   +1 more source

Hepatitis C virus NS3/4A protease cleaves SPG20, a key regulator of lipid droplet turnover, to promote lipid droplet formation [PDF]

Chieko Matsui, Putu Yuliandari, Lin Deng, Takayuki Abe, Ikuo Shoji   +4 more
openalex   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Intracrine FFA4 signaling controls lipolysis at lipid droplets. [PDF]

Nat Chem Biol
O'Brien SL, Tripp E, Barki N, Blondel-Tepaz E, Smith G, Boufersaoui A, Roberts J, Pike JA, Correia J, Miljus T, Bouvier M, Tennant DA, Hudson BD, Gerhart-Hines Z, Milligan G, Schwartz TW, Calebiro D.   +16 more
europepmc   +1 more source