Results 1 to 10 of about 4,703 (99)
Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II. [PDF]
PLoS Pathogens, 2013 We have previously reported on the functional interaction of Lipid II with human alpha-defensins, a class of antimicrobial peptides. Lipid II is an essential precursor for bacterial cell wall biosynthesis and an ideal and validated target for natural ...
Kristen M Varney +13 more
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Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics. [PDF]
PLoS ONE, 2016 Recently we described a novel di-benzene-pyrylium-indolene (BAS00127538) inhibitor of Lipid II. BAS00127538 (1-Methyl-2,4-diphenyl-6-((1E,3E)-3-(1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)pyryl-1-ium) tetrafluoroborate is the first small molecule ...
Jamal Chauhan +12 more
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Biomedicines, 2022 The mechanisms of angiotensin II (Ang II) on regulating adipogenic differentiation and function remain unknown. In this study, we focus on revealing the role of C-terminal-binding protein 1 (CtBP1) on Ang II-mediated adipogenic differentiation and mature
Xiuying Liang +4 more
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Scientific Reports, 2020 Lipid II precursor and its processing by a flippase and peptidoglycan polymerases are considered key hot spot targets for antibiotics. We have developed a fluorescent anisotropy (FA) assay using a unique and versatile probe (fluorescent lipid II) and ...
Adrien Boes +4 more
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Journal of Lipid Research, 2021 : Lipidomics data require consideration of ions with near-identical masses, which comprises among others the Type-II isotopic overlap. This overlap occurs in series of lipid species differing only by number of double bonds (DBs) mainly because of the ...
Marcus Höring +5 more
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New antibiotics against bacterial resistance
Infectio, 2019 La evolución de la resistencia bacteriana ha generado un serio problema de salud pública debido al uso indiscriminado antibioticos, la aplicación de dosis no óptimas, la irregularidad en la toma de medicinas prescritas por el profesional de la salud han
Lorena Liseth Cárdenas
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An Alternative and Conserved Cell Wall Enzyme That Can Substitute for the Lipid II Synthase MurG
mBio, 2021 Almost all bacteria are surrounded by a cell wall, which protects cells from environmental harm. Formation of the cell wall requires the precursor molecule lipid II, which in bacteria is universally synthesized by the conserved and essential lipid II ...
L. Zhang +6 more
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Core Steps of Membrane-Bound Peptidoglycan Biosynthesis: Recent Advances, Insight and Opportunities
Antibiotics, 2015 We are entering an era where the efficacy of current antibiotics is declining, due to the development and widespread dispersion of antibiotic resistance mechanisms. These factors highlight the need for novel antimicrobial discovery.
Alvin C. K. Teo, David I. Roper
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Specificity of the lipid-binding domain of apoC-II for the substrates and products of lipolysis
Journal of Lipid Research, 2001 Functional similarities between colipase and apolipoprotein C-II (apoC-II) in activating lipases suggest that apoC-II may, like colipase, preferentially interact with interfaces containing the substrates and products of lipolysis. To test this hypothesis,
M. Dahim +3 more
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Metabolism Open, 2022 Overweight/obesity is a growing pandemic that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations ...
Thuany Crisóstomo +7 more
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