Results 61 to 70 of about 3,664,759 (313)
Interactions of Novel Phosphonium Dye with Lipid Bilayers: A Molecular Dynamics Study
East European Journal of Physics, 2022 In the present work the 100-ns molecular dynamics simulations (MD) were performed in the CHARMM36m force field using the GROMACS package to estimate the bilayer location and mechanisms of the interaction between the novel phosphonium dye TDV and the ...
Olga Zhytniakivska
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Interaction of hydrophobic polymers with model lipid bilayers
Scientific Reports, 2017 The interaction of nanoscale synthetic materials with cell membranes is one of the key steps determining nanomaterials’ toxicity. Here we use molecular simulations, with atomistic and coarse-grained resolution, to investigate the interaction of three ...
D. Bochicchio +3 more
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The Effect of Tethers on Artificial Cell Membranes: A Coarse-Grained Molecular Dynamics Study. [PDF]
PLoS ONE, 2016 Tethered bilayer lipid membranes (tBLMs) provide a stable platform for modeling the dynamics and order of biological membranes where the tethers mimic the cytoskeletal supports present in biological cell membranes.
William Hoiles +4 more
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Non-Brownian diffusion in lipid membranes: Experiments and simulations.
Biochimica et Biophysica Acta, 2016 The dynamics of constituents and the surface response of cellular membranes-also in connection to the binding of various particles and macromolecules to the membrane-are still a matter of controversy in the membrane biophysics community, particularly ...
R. Metzler +2 more
semanticscholar +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
HIV-1 Gag Polyprotein Affinity to the Lipid Membrane Is Independent of Its Surface Charge
BiomoleculesThe binding of the HIV-1 Gag polyprotein to the plasma membrane is a critical step in viral replication. The association with membranes depends on the lipid composition, but its mechanisms remain unclear.
Zaret G. Denieva +2 more
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Transepidermal water loss: the signal for recovery of barrier structure and function.
Journal of Lipid Research, 1989 Previous studies have demonstrated that perturbations in barrier function stimulate epidermal lipid synthesis and that this increase can be prevented by occlusive membranes.
G Grubauer, P M Elias, K R Feingold
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Odor Discrimination by Lipid Membranes
Membranes, 2023 Odor detection and discrimination in mammals is known to be initiated by membrane-bound G-protein-coupled receptors (GPCRs). The role that the lipid membrane may play in odor discrimination, however, is less well understood.
Troy W. Lowry +3 more
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