Results 61 to 70 of about 3,175,424 (401)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression

Cell Reports, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Irfan J. Lodhi, John M. Dean, Anyuan He, Hongsuk Park, Min Tan, Chu Feng, Haowei Song, Fong-Fu Hsu, Clay F. Semenkovich   +8 more
doaj   +1 more source

Dietary lipids, gut microbiota and lipid metabolism

Reviews in Endocrine & Metabolic Disorders, 2019
The gut microbiota is a central regulator of host metabolism. The composition and function of the gut microbiota is dynamic and affected by diet properties such as the amount and composition of lipids.
M. Schoeler, R. Caesar
semanticscholar   +1 more source

Alcohol effects on hepatic lipid metabolism

Journal of Lipid Research, 2020
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis.
Sookyoung Jeon, R. Carr
semanticscholar   +1 more source

Biological, clinical and population relevance of 95 loci for blood lipids. [PDF]

, 2010
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic ...
Aulchenko, Yurii S, Barbalic, Maja, Bis, Joshua C, Chambers, John, Chasman, Daniel I, Croteau-Chonka, Damien C, Edmondson, Andrew C, Feitosa, Mary F, Fouchier, Sigrid W, Guo, Xiuqing, Hua Zhao, Jing, Isaacs, Aaron, Jin Go, Min, Jin Kim, Young, Johansen, Christopher T, Johnson, Toby, Kim, Kyunga, Koseki, Masahiro, Lamina, Claudia, Lange, Leslie A, Lee, Jong-Young, Li, Mingyao, Li, Xiaohui, Luan, Jian'an, McCarthy, Mark I, McPherson, Ruth, Meitinger, Thomas, Melander, Olle, Montgomery, Grant W, Musunuru, Kiran, Nickerson, Deborah A, Nieminen, Markku S, O'Donnell, Christopher J, Oostra, Ben A, Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Parker, Alex N, Pattaro, Cristian, Pedersen, Nancy L, Peloso, Gina M, Penninx, Brenda WJH, Perola, Markus, Pichler, Irene, Pirruccello, James P, Pramstaller, Peter P, Psaty, Bruce M, Ricketts, Sally L, Rieder, Mark, Ripatti, Samuli, Roberts, Robert, Rose, Lynda M, Rudan, Igor, Ruokonen, Aimo, Sabatti, Chiara, Saharinen, Juha, Salomaa, Veikko, Sanna, Serena, Schlessinger, David, Scott, James, Scuteri, Angelo, Shin Cho, Yoon, Sijbrands, Eric JG, Silander, Kaisa, Sim, Xueling, Sinisalo, Juha, Smit, Johannes H, Smith, Albert V, Smith, Joshua D, Song, Kijoung, Soranzo, Nicole, Spector, Tim D, Stringham, Heather M, Stylianou, Ioannis M, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Thompson, John R, Thorleifsson, Gudmar, Tuomilehto, Jaakko, Twee-Hee Ong, Rick, Uda, Manuela, Uitterlinden, Andre G, Vitart, Veronique, Voight, Benjamin F, Vollenweider, Peter, Waeber, Gérard, Wareham, Nicholas J, Waterworth, Dawn M, Whitfield, John B, Wichmann, H-Erich, Willemsen, Gonneke, Willer, Cristen J, Wilson, James F, Witteman, Jacqueline CM, Wright, Alan F, Yuan, Xin, Zee, Robert YL, Zhang, Weihua, Ziegler, Andreas   +99 more
core  

Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats [PDF]

, 2016
This study reports on a comprehensive comparison of the effects of soy and meat proteins given at the recommended level on physiological markers of metabolic syndrome and the hepatic transcriptome.
A Hagiwara, A Lass, A Shukla, A Subramanian, AM Uhe, B He, BB Albert, C Brandsch, C Chaveroux, CJ Andersen, CW Law, D Eberle, D El Khoury, D Gaidatzis, D Karolchik, D Merico, D Ord, D Tome, DW Gietzen, E Tornberg, G Fromentin, G Sarwar, H Sidransky, HX Yuan, J Cacho, J Schwarz, JI Lee, JL Jewell, JM Beasley, KK Carroll, L Abatangelo, L Noriega-Lopez, LE Matarese, M Friedman, M Shimobayashi, MD Robinson, MD Robinson, ME Ritchie, ML Orgeron, MS Kilberg, N Tachibana, PG Reeves, PM Leung, PM Pereira, R Bourgon, R Hoffenberg, R Hosomi, S Guo, S Madani, S Wen, SM Potter, SN Twigger, T Berry, TG Anthony, V Ranawana, W Gade, W Kang, Y Takahashi   +57 more
core   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study.

Journal of Lipid Research, 1994
Plasma low density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, and apolipoprotein (apo) B, the major protein constituent of LDL, were measured in 1,533 men (mean age 49 +/- 10 years) and 1,597 women (mean age 49 +/- 10 ...
E J Schaefer, S Lamon-Fava, S D Cohn, M M Schaefer, J M Ordovas, W P Castelli, P W Wilson   +6 more
doaj  

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source