Results 71 to 80 of about 1,481,010 (254)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Bidirectional hybrid erythritol-inducible promoter for synthetic biology in Yarrowia lipolytica

Microbial Cell Factories, 2023
Background The oleaginous yeast Yarrowia lipolytica is increasingly used as a chassis strain for generating bioproducts. Several hybrid promoters with different strengths have been developed by combining multiple copies of an upstream activating sequence
Lea Vidal, Esteban Lebrun, Young-Kyoung Park, Guillaume Mottet, Jean-Marc Nicaud   +4 more
doaj   +1 more source

Lipid Abundance and Metabolism Aberrations in Skin Diseases

This Special Issue of Metabolites, entitled “Lipid Abundance and Metabolism Aberrations in Skin Diseases” broadly discusses the issue of lipids that are engaged in pathogenesis, as well as in the clinical course and treatment of dermatoses [..
Julia Nowowiejska
core   +1 more source

Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet [PDF]

, 2009
Background. Dietary polyunsaturated fatty acids (PUFA), in particular the long chain marine fatty acids docosahexaenoic (DHA) and eicosapentaenoic (EPA), are linked to many health benefits in humans and in animal models.
Schothorst, E.M., van, Evert M van Schothorst, Annelies Bunschoten, Jaap Keijer, Molthoff, J.W., Keijer, J., Flachs, P., Bunschoten, A., Kopecky, J., Vink, C., Franssen-Hal, N.L.W., van, Ondrej Kuda, Carolien Vink, Nicole LW Franssen-van Hal, Guido JEJ Hooiveld, Pavel Flachs, Kuda, O., Hooiveld, G.J.E.J., Jan Kopecky, Jos Molthoff   +19 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Investigating the Effects of Statins on Cellular Lipid Metabolism Using a Yeast Expression System [PDF]

, 2009
In humans, defects in lipid metabolism are associated with a number of severe diseases such as atherosclerosis, obesity and type II diabetes. Hypercholesterolemia is a primary risk factor for coronary artery disease, the major cause of premature deaths
Zimnicka, Magdalena, Szkopinska, Anna, Burzynska, Beata, Kania, Magdalena, Wysocka-Kapcinska, Monika, Kiliszek, Marek, Danikiewicz, Witold, Plochocka, Danuta, Leszczynska, Agata, Kaminska, Joanna   +9 more
core   +3 more sources

Synthetic redesign of plant lipid metabolism [PDF]

, 2016
Plant seed lipid metabolism is an area of intensive research, including many examples of transgenic events in which oil composition has been modified.
Sayanova, O. V., Kim, H. J., Haslam, R. P., Napier, J. A., Cahoon, E. B., Sayanova, Olga, Napier, Johnathan, Haslam, Richard   +7 more
core   +1 more source

Glucokinase Inactivation Ameliorates Lipid Accumulation and Exerts Favorable Effects on Lipid Metabolism in Hepatocytes

, 2023
Glucokinase-maturity onset diabetes of the young (GCK-MODY) is a kind of rare diabetes with low incidence of vascular complications caused by GCK gene inactivation.
Jieying Liu, Xinhua Xiao, Ting Xie, Ziyan Xie, Qian Zhang   +4 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Acyl-Lipid Metabolism [PDF]

The Arabidopsis Book, 2010
Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These include providing the core diffusion barrier of the membranes that separates cells and subcellular organelles. This function alone involves more than 10 membrane lipid classes, including the phospholipids, galactolipids, and sphingolipids, and within each class ...
Li-Beisson, Yonghua, Shorrosh, Basil, Beisson, Fred, Andersson, Mats X., Arondel, Vincent, Bates, Philippe D., Baud, Sebastien, Bird, David, Debono, Allan, Durrett, Timithy P., Franke, Rochus B., Graham, Ian A., Katayama, Kenta, Kelly, Amelie A., Larson, Tony, Markham, Jonathan E., Miquel, Martine, Molina, Isabel, Nishida, Ikuo, Rowland, Owen, Samuels, Lacey, Schmid, Katherine M., Wada, Hajime, Welti, Ruth, Xu, Changcheng, Zallot, Rémi, Ohlrogge, John   +26 more
openaire   +6 more sources