Results 71 to 80 of about 2,085,232 (303)
Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency1
Journal of Lipid Research, 2008 Our aim was to characterize HDL subspecies and fat-soluble vitamin levels in a kindred with familial apolipoprotein A-I (apoA-I) deficiency. Sequencing of the APOA1 gene revealed a nonsense mutation at codon −2, Q[−2]X, with two documented homozygotes ...
Raul D. Santos +10 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Untargeted and Targeted Lipidomics Unveil Dynamic Lipid Metabolism Alterations in Type 2 Diabetes
Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with a growing body of evidence suggesting the central role of lipid metabolism in its pathogenesis.
Li Feng +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Lipid Metabolism in Inflammation and Immune Function
, 2022 Lipid metabolism plays an essential role in modulating inflammation within the context of acute and chronic diseases [...
Catherine J. Andersen
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Lipid Abundance and Metabolism Aberrations in Skin Diseases
This Special Issue of Metabolites, entitled “Lipid Abundance and Metabolism Aberrations in Skin Diseases” broadly discusses the issue of lipids that are engaged in pathogenesis, as well as in the clinical course and treatment of dermatoses [..
Julia Nowowiejska
core +1 more source
, 2023 Glucokinase-maturity onset diabetes of the young (GCK-MODY) is a kind of rare diabetes with low incidence of vascular complications caused by GCK gene inactivation.
Jieying Liu +4 more
core +1 more source
The Arabidopsis Book, 2010 Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These include providing the core diffusion barrier of the membranes that separates cells and subcellular organelles. This function alone involves more than 10 membrane lipid classes, including the phospholipids, galactolipids, and sphingolipids, and within each class ...
Li-Beisson, Yonghua +26 more
openaire +6 more sources
Cardiovascular TherapeuticsCardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, and hyperlipidemia is one major inducing factor of CVD. It is worthy to note that fucoidans are reported to have hypolipidemic activity with species specificity ...
Yan Zhang +5 more
doaj +1 more source