Results 61 to 70 of about 2,085,232 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Studies on the effect of oestrogen treatment on the lipid metabolism of the male chick (gallus domesticus) [PDF]

, 1986
The aim of this study was to investigate the early (
Talbot, Steven
core  

PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression

Cell Reports, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Irfan J. Lodhi, John M. Dean, Anyuan He, Hongsuk Park, Min Tan, Chu Feng, Haowei Song, Fong-Fu Hsu, Clay F. Semenkovich   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Divergent cell-type specific hypoxia responses in human stem cell-derived and primary islets

Scientific Reports
The success of stem cell-derived islet (SC-islet) therapy for type 1 diabetes is limited by poor graft survival in the hypoxic post-transplantation microenvironment. While the response of SC-islets to chronic hypoxia has been studied, a direct comparison
Kameron Bradley, Camryn Moore, Matthew Ishahak, Marlie M. Maestas, Daniel A. Veronese-Paniagua, Jeffrey R. Millman   +5 more
doaj   +1 more source

Plasma apolipoprotein changes in the triglyceride-rich lipoprotein fraction of human subjects fed a fat-rich meal

Journal of Lipid Research, 1988
Twenty two subjects (9 males, 13 females) were fed a fat-rich meal (1 g of fat/kg body weight). Triglyceride-rich lipoproteins (TRL) were isolated by ultracentrifugation (d less than 1.006 g/ml) from blood drawn 0, 3, 6, 9, and 12 hr after the meal ...
J S Cohn, J R McNamara, S D Cohn, J M Ordovas, E J Schaefer   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Integrated Analysis of Gut Microbiome and Lipid Metabolism in Mice Infected with Carbapenem-Resistant Enterobacteriaceae

, 2022
The disturbance in gut microbiota composition and metabolism has been implicated in the process of pathogenic bacteria infection. However, the characteristics of the microbiota and the metabolic interaction of commensals–host during pathogen ...
Peng, Yuanyuan, Liu, Xijian, Peng He, Xiaohui Liu, Jiamin Zhu, Deng, Guoying, Xijian Liu, Zhong Zhang, Yumin Liu, Yuanyuan Peng, Liu, Xiaohui, Feng, Meiqing, Zhu, Jiamin, Zhao, Linjing, Ning Zhang, He, Peng, Liu, Yumin, Zhang, Zhong, Guoying Deng, Linjing Zhao, Meiqing Feng, Zhang, Ning   +21 more
core   +1 more source

Bidirectional hybrid erythritol-inducible promoter for synthetic biology in Yarrowia lipolytica

Microbial Cell Factories, 2023
Background The oleaginous yeast Yarrowia lipolytica is increasingly used as a chassis strain for generating bioproducts. Several hybrid promoters with different strengths have been developed by combining multiple copies of an upstream activating sequence
Lea Vidal, Esteban Lebrun, Young-Kyoung Park, Guillaume Mottet, Jean-Marc Nicaud   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source