Results 81 to 90 of about 779,747 (305)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Exploring sex bias in cardiometabolic diseases

Lipids in Health and Disease
Cardiometabolic diseases (CMDs), such as cardiovascular diseases (CVDs), obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH), represent an alarming burden on healthcare systems. Differences in the prevalence, progression
Tania Guillemette, David Rhainds, Océane Robert, Catherine Mounier   +3 more
doaj   +1 more source

Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood

Genes and Diseases, 2019
Overfeeding in early life is associated with obesity and insulin resistance in adulthood. In the present study, a well-characterized mouse model was used to investigate whether neonatal overfeeding increases susceptibility to the development of non ...
Juan Du, Xuemei Cao, Junlin Diao, Qijuan Zhang, Chuan Peng, Jibin Li, Xiaoqiu Xiao   +6 more
doaj   +1 more source

Fatty Acyl Esters of Hydroxy Fatty Acid (FAHFA) Lipid Families

, 2020
Fatty Acyl esters of Hydroxy Fatty Acids (FAHFA) encompass three different lipid families which have incorrectly been classified as wax esters. These families include (i) Branched-chain FAHFAs, involved in the regulation of glucose metabolism and ...
Paul L. Wood
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Lipid metabolism in newborn infants at birth. Obstetrical-pediatric aspects

, 1980
Lipid metabolism in newborn infants at birth.
Ferrazzani, Sergio, Miggiano, Giacinto Abele Donato   +1 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Psychological flexibility patterns in patients with type 2 diabetes mellitus and its associations with self-care behavior and medical condition

BMC Psychology
Background This study aimed to elucidate the relationships of psychological flexibility (PF) patterns in patients with type 2 diabetes mellitus with physiological and lifestyle indexes.
Taiki Shima, Aiko Ohya, Hisashi Makino, Yoko Omura-Ohata, Tamiko Tamanaha, Mayu Tochiya, Ryo Koezuka, Masaki Matsubara, Tsutomu Tomita, Michio Noguchi, Yuka Munemoto, Miki Nishimura, Kiminori Hosoda   +12 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Impact of age on the metabolism of VLDL, IDL, and LDL apolipoprotein B-100 in men.

Journal of Lipid Research, 1995
Levels of plasma very low density lipoprotein (VLDL) and low density lipoprotein (LDL) constituents increase with age. In an attempt to further define the mechanisms responsible for these changes, kinetic studies of VLDL and LDL apolipoprotein (apo) B ...
J.S. Millar, A.H. Lichtenstein, M. Cuchel, G.G. Dolnikowski, D.L. Hachey, J.S. Cohn, E.J. Schaefer   +6 more
doaj   +1 more source