Material properties of lipid microdomains: force-volume imaging study of the effect of cholesterol on lipid microdomain rigidity. [PDF]
Biophys J, 2010 The effect of cholesterol (CHOL) on the material properties of supported lipid bilayers composed of lipid mixtures that mimic the composition of lipid microdomains was studied by force-volume (FV) imaging under near-physiological conditions. These studies were carried out with lipid mixtures of dioleoylphosphatidylcholine, dioleoylphosphatidylserine ...
An H +4 more
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Analysis of lipid-composition changes in plasma membrane microdomains[S] [PDF]
Journal of Lipid Research, 2015 Sphingolipids accumulate in plasma membrane microdomain sites, such as caveolae or lipid rafts. Such microdomains are considered to be important nexuses for signal transduction, although changes in the microdomain lipid components brought about by ...
Hideo Ogiso +2 more
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Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease. [PDF]
Acta Neuropathol Commun, 2016 Decreased neuronal insulin receptor (IR) signaling in Alzheimer’s disease is suggested to contribute to synaptic loss and neurodegeneration. This work shows that alteration of membrane microdomains increases IR levels and signaling, as well as neuronal ...
Herzer S +4 more
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Nuclear lipid microdomain as resting place of dexamethasone to impair cell proliferation. [PDF]
Int J Mol Sci, 2014 The action of dexamethasone is initiated by, and strictly dependent upon, the interaction of the drug with its receptor followed by its translocation into the nucleus where modulates gene expression.
Cataldi S +13 more
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Nuclear lipid microdomain as place of interaction between sphingomyelin and DNA during liver regeneration. [PDF]
Int J Mol Sci, 2013 Nuclear sphingomyelin is a key molecule for cell proliferation. This molecule is organized with cholesterol and proteins to form specific lipid microdomains bound to the inner nuclear membrane where RNA is synthesized.
Albi E +6 more
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Nuclear lipid microdomains regulate cell function [PDF]
Communicative & Integrative Biology, 2009 The lipids present in the nuclei play different roles in relation to their localization. They are composed by high levels of phosphatidylcholine and sphingomyelin strongly linked with cholesterol. The nuclear lipid composition shows many modifications during cell life due to the presence and activity of some specific enzymes such as sphingomyelinase ...
Elisabetta Albi, Maristella Villani
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Lipid microdomains in cell surface membranes
Current Opinion in Structural Biology, 1997 Lipid microdomains within cell membranes are detected by a variety of experimental techniques, each of which characterizes microdomains on a different time and spatial scale. The sum of the data on lipid microdomains has yet to be integrated into a single model of cell membrane structure.
Michael Edidin
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The 'lipid raft' microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling. [PDF]
Biochemical Society Symposium, 2005 Reggie-1 and reggie-2 are two evolutionarily highly conserved proteins which are up-regulated in retinal ganglion cells during regeneration of lesioned axons in the goldfish optic nerve. They are located at the cytoplasmic face of the plasma membrane and
Claudia A. O. Stuermer, Helmut Plattner
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Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition [PDF]
PeerJ, 2018 Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2.
Christine Hellwing +4 more
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Biosynthesis of the anti‐lipid‐microdomain sphingoid base 4,14‐sphingadiene by the ceramide desaturase FADS3 [PDF]
The FASEB Journal, 2020 Sphingolipids are multifunctional lipids. Among the sphingolipid‐component sphingoid bases, 4,14‐sphingadiene (SPD) is unique such that it has a cis double bond with a bent structure.
Keisuke Jojima +4 more
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