Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]
Journal of Cell Biology, 2001 Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH +7 more
core +6 more sources
Nuclear lipid microdomain as resting place of dexamethasone to impair cell proliferation. [PDF]
Int J Mol Sci, 2014 The action of dexamethasone is initiated by, and strictly dependent upon, the interaction of the drug with its receptor followed by its translocation into the nucleus where modulates gene expression.
Cataldi S +13 more
europepmc +4 more sources
Detergent-resistant plasma membrane proteomes for elucidating microdomain functions in plant cells [PDF]
Frontiers in Plant Science, 2013 Although proteins and lipids have been assumed to be distributed homogeneously in the plasma membrane (PM), recent studies suggest that the PM is non-uniform, forming a structure that includes a number of lateral domains enriched in specific components ...
Daisuke eTakahashi +4 more
doaj +3 more sources
Phospholipase d promotes lipid microdomain-associated signaling events in mast cells. [PDF]
J Immunol, 2009 Lisboa FA, Peng Z, Combs CA, Beaven MA.
europepmc +4 more sources
Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease. [PDF]
Acta Neuropathol Commun, 2016 Decreased neuronal insulin receptor (IR) signaling in Alzheimer’s disease is suggested to contribute to synaptic loss and neurodegeneration. This work shows that alteration of membrane microdomains increases IR levels and signaling, as well as neuronal ...
Herzer S +4 more
europepmc +2 more sources
Nuclear lipid microdomain as place of interaction between sphingomyelin and DNA during liver regeneration. [PDF]
Int J Mol Sci, 2013 Nuclear sphingomyelin is a key molecule for cell proliferation. This molecule is organized with cholesterol and proteins to form specific lipid microdomains bound to the inner nuclear membrane where RNA is synthesized.
Albi E +6 more
europepmc +2 more sources
Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition [PDF]
PeerJ, 2018 Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2.
Christine Hellwing +4 more
doaj +3 more sources
α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein [PDF]
Journal of Lipid Research, 2015 α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent. In vitro, its free radical-scavenging antioxidant action has been widely demonstrated.
Sterenn Davis +6 more
doaj +2 more sources
Feeding-fasting dependent recruitment of membrane microdomain proteins to lipid droplets purified from the liver. [PDF]
PLoS ONE, 2017 Lipid droplets (LDs) are cellular stores of neutral fat that facilitate lipid and protein trafficking in response to metabolic cues. Unlike other vesicles, the phospholipid membrane on the LD is a monolayer.
Kritika Sadh, Priyanka Rai, Roop Mallik
doaj +2 more sources
An Association Between Peptidoglycan Synthesis and Organization of the
mBio, 2013 The ExPortal of Streptococcus pyogenes is a focal microdomain of the cytoplasmic membrane that clusters the translocons of the general secretory pathway with accessory factors to facilitate the maturation of secreted polypeptides.
Luis Alberto Vega +2 more
doaj +3 more sources