Results 91 to 100 of about 1,061,660 (313)
Nature Communications, 2016 The development of neuronal circuits is controlled by guidance molecules that are hypothesized to interact with the cholesterol-enriched domains of the plasma membrane termed lipid rafts.
S. Averaimo +7 more
semanticscholar +1 more source
Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source
Scientific Reports, 2017 The membrane disruption activities of kalata B1 (kB1) were investigated using molecular dynamics simulations with membrane models. The models were constructed to mimic the lipid microdomain formation in membranes of HIV particle, HIV-infected cell, and ...
Wanapinun Nawae +2 more
doaj +1 more source
Contributions of quantitative proteomics to understanding membrane microdomains
Journal of Lipid Research, 2009 Membrane microdomains, e.g., lipid rafts and caveolae, are crucial cell surface organelles responsible for many cellular signaling and communication events, which makes the characterization of their proteomes both interesting and valuable. They are large
Yu Zi Zheng, Leonard J. Foster
doaj +1 more source
Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic Targets
Frontiers in Microbiology, 2020 Coronaviruses are enveloped, single-stranded, positive-sense RNA viruses that can infect animal and human hosts. The infection induces mild or sometimes severe acute respiratory diseases.
Katia Fecchi +6 more
doaj +1 more source
Advanced Science, EarlyView.The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu +8 more
wiley +1 more source
Protein-sphingolipid interactions within cellular membraness⃞
Journal of Lipid Research, 2008 Each intracellular organelle critically depends on maintaining its specific lipid composition that in turn contributes to the biophysical properties of the membrane.
Per Haberkant +8 more
doaj +1 more source
Cardiovascular Diabetology, 2017 Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a ‘wicked triumvirate’: (i) increasing the risk and incidence of IHD and ...
J. Russell +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei +14 more
wiley +1 more source
Functions of lipid raft membrane microdomains at the blood–brain barrier [PDF]
Journal of Molecular Medicine, 2009 The blood-brain barrier (BBB) is a highly specialized structural and functional component of the central nervous system that separates the circulating blood from the brain and spinal cord parenchyma. Brain endothelial cells (BECs) that primarily constitute the BBB are tightly interconnected by multiprotein complexes, the adherens junctions and the ...
Dodelet-Devillers, Aurore +7 more
openaire +5 more sources