Results 101 to 110 of about 1,061,660 (313)

Signalling at membrane contact sites: two membranes come together to handle second messengers [PDF]

, 2016
It is now clear that many intracellular signals result from multiple membrane-bound compartments acting in concert. Membrane contact sites, regions of close apposition between organelles, have emerged as major points of convergence during signalling, as ...
Levine, TP, Patel, S
core   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

The potent effect of mycolactone on lipid membranes. [PDF]

PLoS Pathogens, 2018
Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and ...
Milène Nitenberg, Anaïs Bénarouche, Ofelia Maniti, Estelle Marion, Laurent Marsollier, Julie Géan, Erick J Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P Girard-Egrot   +9 more
doaj   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, EarlyView.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Coordination of bilayer properties by an inward-rectifier K+ channel is a cooperative process driven by protein-lipid interaction

Journal of Structural Biology: X
Physical properties of biological membranes directly or indirectly govern biological processes. Yet, the interplay between membrane and integral membrane proteins is difficult to assess due to reciprocal effects between membrane proteins, individual ...
Evan J. van Aalst, Maryam Yekefallah, Roy A. M. van Beekveld, Eefjan Breukink, Markus Weingarth, Benjamin J. Wylie   +5 more
doaj   +1 more source

Refurbishing the plasmodesmal chamber: a role for lipid bodies?

Frontiers in Plant Science, 2014
Lipid bodies (LBs) are universal constituents of both animal and plant cells. They are produced by specialised membrane domains at the tubular endoplasmic reticulum (ER), and consist of a core of neutral lipids and a surrounding monolayer of phospholipid
Laju K Paul, Paivi Liisa Hannele Rinne, Christiaan eVan Der Schoot   +2 more
doaj   +1 more source

Echovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro

Microorganisms, 2020
Echovirus-30 (E-30) is a non-polio enterovirus responsible for meningitis outbreaks in children worldwide. To gain access to the central nervous system (CNS), E-30 first has to cross the blood-brain barrier (BBB) or the blood-cerebrospinal fluid barrier (
Marie Wiatr, Simon Staubach, Ricardo Figueiredo, Carolin Stump-Guthier, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Franz-Georg Hanisch, Henriette Rudolph, Tobias Tenenbaum   +9 more
doaj   +1 more source

A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]

PLoS Pathogens, 2014
The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
doaj   +1 more source

Biased signalling is an essential feature of TLR4 in glioma cells [PDF]

, 2016
A distinct feature of the Toll-like receptor 4 (TLR4) is its ability to trigger both MyD88-dependent and MyD88-independent signalling, culminating in activation of pro-inflammatory NF-κB and/or the antiviral IRF3.
Bieback, Karen, Cottrell, Graeme S., Heilemann, Mike, Krueger, Carmen L., Volk, Katharina, Widera, Darius, Zeuner, Marie-Theres   +6 more
core   +1 more source