Results 111 to 120 of about 1,147,179 (336)

The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]

, 2006
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, Thomas, Jarvis, Rosemary M., Johannes, Ludger, Lord, Mike, Platt, Frances M., Roberts, L. M. (Lynne M.), Sillence, Daniel J., Smith, Daniel C.   +7 more
core   +3 more sources

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Refurbishing the plasmodesmal chamber: a role for lipid bodies?

Frontiers in Plant Science, 2014
Lipid bodies (LBs) are universal constituents of both animal and plant cells. They are produced by specialised membrane domains at the tubular endoplasmic reticulum (ER), and consist of a core of neutral lipids and a surrounding monolayer of phospholipid
Laju K Paul, Paivi Liisa Hannele Rinne, Christiaan eVan Der Schoot   +2 more
doaj   +1 more source

Echovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro

Microorganisms, 2020
Echovirus-30 (E-30) is a non-polio enterovirus responsible for meningitis outbreaks in children worldwide. To gain access to the central nervous system (CNS), E-30 first has to cross the blood-brain barrier (BBB) or the blood-cerebrospinal fluid barrier (
Marie Wiatr, Simon Staubach, Ricardo Figueiredo, Carolin Stump-Guthier, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Franz-Georg Hanisch, Henriette Rudolph, Tobias Tenenbaum   +9 more
doaj   +1 more source

A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]

PLoS Pathogens, 2014
The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
doaj   +1 more source

Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication

Chemistry – A European Journal, EarlyView.
This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin, Xinan Huang, Voichita Mihali, Cornelia G. Palivan   +3 more
wiley   +1 more source

Weak Glycolipid Binding of a Microdomain-Tracer Peptide Correlates with Aggregation and Slow Diffusion on Cell Membranes [PDF]

, 2012
10.1371/journal.pone.0051222PLoS ...
A Kakio, A Kakio, A Onufriev, Artur Matysik, B Hess, B Hess, B Windschiegl, BC Yowler, CA Lasagna-Reeves, CM Yip, CM Yip, CM Yip, D Lingwood, D Van der Spoel, D Zhang, DA Bateman, E Lindahl, G Bussi, GM Kuziemko, H Ewers, HJC Berendsen, J Fantini, J Fantini, J Fantini, J McLaurin, J McLaurin, J McLaurin, J Sankaran, JJ Kremer, JJ Kremer, JV Rocheleau, JV Rocheleau, K Bacia, K Bacia, K Ikeda, K Yanagisawa, K Yanagisawa, K Yanagisawa, K Yanagisawa, Kamila Oglęcka, L Johannes, L Saavedra, LP Choo-Smith, LP Choo-Smith, M Levy, M Stefl, M Wakabayashi, Manoj Manna, Maria Ruhnow, Michael Koval, MJ Widenbrant, MP Williamson, MR Baldwin, N Yamamoto, P Antes, P Critchley, R Pellizzari, R Roy, Rachel Kraut, RD Johnson, RH Swendsen, S Hebbar, S Inaba, S Manes, S Nag, S Steinert, SA Poulsen, SA Waschuk, Susana Geifman-Shochat, T Ariga, T Ariga, T Dertinger, T Valdes-Gonzalez, Thorsten Wohland, Tim Lauterbach, TS van Zanten, V Hornak, W Kabsch, W Romer, WI Weis, Yaofeng Wang, YC Lee, Yudi Wisantoso, Yuguang Mu, Z Petrasek   +84 more
core   +3 more sources

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.

PLoS Pathogens, 2015
Persistent activation of NF-κB by the Human T-cell leukemia virus type 1 (HTLV-1) oncoprotein, Tax, is vital for the development and pathogenesis of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Rajeshree Pujari, Richard Hunte, Remy Thomas, Louise van der Weyden, Dan Rauch, Lee Ratner, Jennifer K Nyborg, Juan Carlos Ramos, Yoshimi Takai, Noula Shembade   +9 more
doaj   +1 more source

Analysis of Lipids, Fatty Acid, and Cholesterol in Membrane Microdomains [PDF]

, 2023
Martin‐Paul Agbaga, Mark E. McClellan, Michael H. Elliott   +2 more
openalex   +1 more source