Results 111 to 120 of about 1,061,660 (313)

Impact of Interfacial Viscosity on the Robustness of Phospholipid‐Decorated Fluid Cell Scaffolds

Advanced NanoBiomed Research, EarlyView.
Viscosity‐tunable fluid scaffolds are developed by decorating a perfluorocarbon interface with phospholipid membranes (IPLMs) of varying unsaturated lipid contents. A solid‐like IPLM is cell‐adhesive but brittle, whereas the least viscous IPLM does not allow cell adhesion. Moderately viscous IPLMs serve as highly adaptive cellular scaffolds.
Junhong Zhou, Jun Nakanishi
wiley   +1 more source

The order of rafts [PDF]

EMBO reports, 2003
The EuroConference on Microdomains, Lipid Rafts and Caveolae was held in Tomar, Portugal, from 17 to 22 May 2003. This joint EURESCO Conference/EMBO workshop was organized by G. van Meer and K. Simons and was the second meeting in a series that was initiated by K. Fiedler in 2001.
Zurzolo, Chiara, van Meer, Gerrit, Mayor, Satyajit   +2 more
openaire   +3 more sources

Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. [PDF]

, 2004
Insulin stimulation of adipocytes resulted in the recruitment of atypical PKC (PKCzeta/lambda) to plasma membrane lipid raft microdomains. This redistribution of PKCzeta/lambda was prevented by Clostridium difficile toxin B and by cholesterol depletion ...
Hwang, Joseph B, Kanzaki, Makoto, Mora, Silvia, Pessin, Jeffrey E, Saltiel, Alan R   +4 more
core   +1 more source

LPS- or Pseudomonas aeruginosa-mediated activation of the macrophage TLR4 signaling cascade depends on membrane lipid composition

PeerJ, 2016
It is well known that PUFA impede the LPS-mediated activation of the transcription factor NFkappaB. However, the underlying mode of action has not been clarified yet. To address this issue in a comprehensive approach, we used the monocyte/macrophage cell
A. Schoeniger, H. Fuhrmann, J. Schumann
semanticscholar   +1 more source

The Inner Nuclear Membrane Has a Unique Lipid Signature

BioEssays, EarlyView.
The inner nuclear membrane (INM) has a distinct lipid profile, most notably characterized by high enrichment of phosphatidylserine (PS). In this review, Yang Niu and Tamas Balla summarize recent advances in elucidating the INM's lipid composition and related metabolic pathways, while elaborating further on their potential functional roles.
Yang Niu, Tamas Balla
wiley   +1 more source

Nuclear Lipid Microdomains Regulate Daunorubicin Resistance in Hepatoma Cells [PDF]

International Journal of Molecular Sciences, 2018
Daunorubicin is an anticancer drug, and cholesterol is involved in cancer progression, but their relationship has not been defined. In this study, we developed a novel experimental model that utilizes daunorubicin, cholesterol, and daunorubicin plus cholesterol in the same cells (H35) to search for the role of nuclear lipid microdomains, rich in ...
Codini M, Conte C, Cataldi S, Arcuri C, Lazzarini A, Ceccarini MR, Patria F, Floridi A, Mecca C, Ambesi-Impiombato FS, Beccari T, Curcio F, Albi E.   +12 more
openaire   +4 more sources

Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.

PLoS Pathogens, 2015
Persistent activation of NF-κB by the Human T-cell leukemia virus type 1 (HTLV-1) oncoprotein, Tax, is vital for the development and pathogenesis of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Rajeshree Pujari, Richard Hunte, Remy Thomas, Louise van der Weyden, Dan Rauch, Lee Ratner, Jennifer K Nyborg, Juan Carlos Ramos, Yoshimi Takai, Noula Shembade   +9 more
doaj   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Molecular theory of hydrophobic mismatch between lipids and peptides

, 2001
Effects of the mismatch between the hydrophobic length, d, of transmembrane alpha helices of integral proteins and the hydrophobic thickness, D_h, of the membranes they span are studied theoretically utilizing a microscopic model of lipids. In particular,
Daniel Duque, Froud R. J., Kirill Katsov, M. Schick, Xiao-jun Li   +4 more
core   +2 more sources

Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity [PDF]

, 2014
The ExPortal protein secretion organelle in Streptococcus pyogenes is an anionic phospholipid-containing membrane microdomain enriched in Sec translocons and postsecretion protein biogenesis factors.
Caparon, Michael G., Nylander, Andrew B., Port, Gary C., Vega, Luis A.   +3 more
core   +2 more sources