Results 141 to 150 of about 1,061,660 (313)

Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle–mediated release of ezrin to inhibit tumour cell movement

Journal of Extracellular Vesicles, 2020
Tumour metastasis suppressor KAI1/CD82 inhibits tumour cell movement. As a transmembrane protein, tetraspanin CD82 bridges the interactions between membrane microdomains of lipid rafts and tetraspanin-enriched microdomains (TEMs). In this study, we found
Chao Huang, Franklin A. Hays, James J. Tomasek, Siribhinya Benyajati, Xin A. Zhang   +4 more
doaj   +1 more source

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Journal of Cell Biology, 2003
Localization of signaling complexes to specific microdomains coordinates signal transduction at the plasma membrane. Using immunogold electron microscopy of plasma membrane sheets coupled with spatial point pattern analysis, we have visualized ...
I. Prior, C. Muncke, R. Parton, J. Hancock   +3 more
semanticscholar   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains

Cell Reports, 2013
Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extremely stable lipid microdomains by "
Zhao, Hongxia, Michelot, Alphée, Koskela, Essi V, Tkach, Vadym, Stamou, Dimitrios, Drubin, David G, Lappalainen, Pekka   +6 more
openaire   +7 more sources

Ion channel regulation by phosphoinositides analyzed with VSPs – PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility

Frontiers in Pharmacology, 2015
The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P2 are cellular signals that regulate ion channels.
Alexandra eRjasanow, Michael G. Leitner, Veronika eThallmair, Christian R Halaszovich, Dominik eOliver   +4 more
doaj   +1 more source

ErbB receptorok szerepe epitél eredetű tumorokban: receptor tirozinkinázok, mint a tumor ellenes terápiák lehetséges target molekulái. = Role of ErbB receptors in epithelial tumors: receptor tyrosine kinases as targets for anticancer therapy. [PDF]

, 2007
Az erbB2-erbB2 és erbB2-erbB1 molekulák homo- és heteroasszociációja - akárcsak más erbB hetero-oligomereké - fontos szerepet játszhatnak a jelátvitelben így az immunoterápiában is.
Barok, Márk, Fazekas, Zsolt, Horváth, Gábor, Ibrahim Shehu, Mustapha, Petrás, Miklós, Sebestyén, Zsolt, Szöllősi, János, Vereb, György, Zsebik, Barbara   +8 more
core  

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

Clinical Genetics, EarlyView.
Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré, Nicolas Bourgon, Dhruvin Akbari, Jeanne Porée, Valentina Serpieri, Marine Panza, Lynda Haddad, Patrick Nitschké, Jacqueline Aziza, Cristina Matt, Enza Maria Valente, Patricia Gargallo, Charlotte Dubucs, Tania Attié‐Bitach, Michel R. Leroux, Sophie Thomas   +19 more
wiley   +1 more source

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function [PDF]

The Journal of Physiology, 2010
Many types of ion channel localize to cholesterol and sphingolipid-enriched regions of the plasma membrane known as lipid microdomains or 'rafts'. The precise physiological role of these unique lipid microenvironments remains elusive due largely to difficulties associated with studying these potentially extremely small and dynamic domains. Nevertheless,
openaire   +3 more sources

Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration*

Journal of Biological Chemistry, 2010
CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion and metastasis. Proteolytic cleavage of CD44 plays a critical role in the migration of tumor cells and is regulated by factors present in the tumor ...
T. Murai, Y. Maruyama, K. Mio, H. Nishiyama, M. Suga, C. Sato   +5 more
semanticscholar   +1 more source