Results 141 to 150 of about 1,147,179 (336)

The Influence of Lipid Microdomain Heterogeneity on Protein-Protein Interactions: Proteomic Analysis of Co-Immunoprecipitated Binding Partners of P450 1A2 and P450 3A in Rat Liver Microsomes. [PDF]

Drug Metab Dispos, 2023
Reed JR, Guidry JJ, Eyer M, Backes WL.
europepmc   +1 more source

Disruption of Lipid Raft Microdomains, Regulation of CD38, TP53, and MYC Signaling, and Induction of Apoptosis by Lomitapide in Multiple Myeloma Cells [PDF]

, 2022
Mohamed E.M. Saeed, Joelle C. Boulos, SABRINA B. MÜCKLICH, Ellen Leich, Manik Chatterjee, Sabine M. Klauck, Thomas Efferth   +6 more
openalex   +1 more source

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Journal of Cell Biology, 2003
Localization of signaling complexes to specific microdomains coordinates signal transduction at the plasma membrane. Using immunogold electron microscopy of plasma membrane sheets coupled with spatial point pattern analysis, we have visualized ...
I. Prior, C. Muncke, R. Parton, J. Hancock   +3 more
semanticscholar   +1 more source

Molecular theory of hydrophobic mismatch between lipids and peptides

, 2001
Effects of the mismatch between the hydrophobic length, d, of transmembrane alpha helices of integral proteins and the hydrophobic thickness, D_h, of the membranes they span are studied theoretically utilizing a microscopic model of lipids. In particular,
Daniel Duque, Froud R. J., Kirill Katsov, M. Schick, Xiao-jun Li   +4 more
core   +2 more sources

Daptomycin-Resistant Enterococcus faecalis Diverts the Antibiotic Molecule from the Division Septum and Remodels Cell Membrane Phospholipids [PDF]

, 2013
Treatment of multidrug-resistant enterococci has become a challenging clinical problem in hospitals around the world due to the lack of reliable therapeutic options. Daptomycin (DAP), a cell membrane-targeting cationic antimicrobial lipopeptide, is the
Arias, Arias, Arias, Barák, Bayer, Bertsche, Bogdanov, Boucher, CLSI, Cotroneo, Davlieva, Dixit, Fishov, Ganz, Hachmann, Hachmann, Hall, Jones, Jordan, Kawai, Kicia, Kristich, Kullar, Lunde, Mileykovskaya, Mileykovskaya, Mileykovskaya, Mishra, Mishra, Mishra, Mukhopadhyay, Munita, Munita, Munoz-Price, Muraih, Muraih, Panesso, Pereira, Petit, Pogliano, Pogliano, Rosch, Sabol, Tsai, Vega, Yang, Zasloff   +46 more
core   +2 more sources

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Membrane-Microdomain Localization of Amyloid β-Precursor Protein (APP) C-terminal Fragments Is Regulated by Phosphorylation of the Cytoplasmic Thr668 Residue*

Journal of Biological Chemistry, 2012
Background: Phosphorylation of amyloid β-precursor protein (APP) at Thr668 alters the conformation of its cytoplasmic domain. Results: Phosphorylation of APP C-terminal fragments (pCTFs) at Thr668 decreases membrane lipid binding.
T. Matsushima, Yuhki Saito, J. Elliott, Kanae Iijima-Ando, M. Nishimura, N. Kimura, Saori Hata, Tohru Yamamoto, T. Nakaya, Toshiharu Suzuki   +9 more
semanticscholar   +1 more source

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. [PDF]

, 2015
Nowadays we understand cell membranes not as a simple double lipid layer but as a collection of complex and dynamic protein-lipid structures and microdomains that serve as functional platforms for interacting signaling lipids and proteins.
Balogh, Gábor, Busquets, Xavier, Escribá, Pablo V., Harwood, John L., Horváth, Ibolya, Inokuchi, Jin-ichi, Török, Zsolt, Vígh, László   +7 more
core   +1 more source

Mechanism elucidation of cell‐selective fluorescent probes

Smart Molecules, EarlyView.
This perspective outlines five mechanistic strategies—Protein‐oriented, carbohydrate‐oriented, lipid‐oriented, gating‐oriented, and metabolism‐oriented live‐cell distinctions—for achieving cell‐selective fluorescence in live‐cell imaging. By classifying probes based on their interactions with proteins, carbohydrates, lipids, transporters, or metabolic ...
Sourav Sarkar, Young‐Tae Chang
wiley   +1 more source

Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle–mediated release of ezrin to inhibit tumour cell movement

Journal of Extracellular Vesicles, 2020
Tumour metastasis suppressor KAI1/CD82 inhibits tumour cell movement. As a transmembrane protein, tetraspanin CD82 bridges the interactions between membrane microdomains of lipid rafts and tetraspanin-enriched microdomains (TEMs). In this study, we found
Chao Huang, Franklin A. Hays, James J. Tomasek, Siribhinya Benyajati, Xin A. Zhang   +4 more
doaj   +1 more source