Results 171 to 180 of about 1,147,179 (336)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Hypercapnia Effects on Lung Function

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
CO2 is a signaling molecule that disrupts alveolar fluid clearance and ion transport, impairs alveolar repair, and promotes mitochondrial and endoplasmic reticulum dysfunction. It suppresses innate immunity, host defense, and inflammation, while increasing airway contractility.
Seungseo Choi, Laura A. Dada, Jacob I. Sznajder   +2 more
wiley   +1 more source

Lipid composition of microdomains is altered in a cell model of Gaucher disease [PDF]

, 2008
Leanne K. Hein, Stephen Duplock, John J. Hopwood, Maria Fuller   +3 more
openalex   +1 more source

Surface Symphony: Orchestrating DPPC/DOPC Monolayer Behavior

Microscopy Research and Technique, Volume 89, Issue 2, Page 207-217, February 2026.
Langmuir trough and atomic force microscopy reveals the physical nature of DPPC and DOPC mixed monolayers. ABSTRACT This study investigates the impact of environmental factors and lipid composition on the structural and morphological properties of DPPC/DOPC (1,2‐Dipalmitoyl‐sn‐glycero‐3‐phosphocholine/1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine ...
Wisnu Arfian A. Sudjarwo, Jose L. Toca‐Herrera   +1 more
wiley   +1 more source

Individuális stresszválasz heterogén sejtpopulációban = Individual stress response in heterogeneous cell population [PDF]

, 2013
A hősokkválasz a természetben található egyik legősibb, evolúció során megőrzött védelmi mechanizmus. A sejtek környezeti változásokra adott válaszának ill.
Gombos, Imre, Horváth, Ibolya, Török, Zsolt, Vígh, László   +3 more
core  

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

Clinical Genetics, Volume 109, Issue 2, Page 305-315, February 2026.
Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré, Nicolas Bourgon, Dhruvin Akbari, Jeanne Porée, Valentina Serpieri, Marine Panza, Lynda Haddad, Patrick Nitschké, Jacqueline Aziza, Cristina Matt, Enza Maria Valente, Patricia Gargallo, Charlotte Dubucs, Tania Attié‐Bitach, Michel R. Leroux, Sophie Thomas   +19 more
wiley   +1 more source

Ion Channel Regulation in Caveolae and Its Pathological Implications

Cells
Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation.
Jianyi Huo, Liangzhu Mo, Xiaojing Lv, Yun Du, Huaqian Yang   +4 more
doaj   +1 more source

Membrane rafts in T cell activation: A spotlight on CD28 costimulation [PDF]

, 2017
Abrahamsen, Acuto, Ambach, Asanov, August, Bi, Billadeau, Bjørgo, Byrum, Chiang, Chuang, Comrie, Davis, Dennehy, Dupré, Dustin, Eggeling, Esensten, Fischer, Garçon, Gaus, Golub, Gri, Harada, Harder, Harding, Hayashi, Head, Holdorf, Hui, June, Kabouridis, Kallikourdis, Kamphorst, Kenworthy, Kim, Kong, Krawczyk, Kündig, Lasserre, Ledbetter, Lee, Liang, Lichtenberg, Lingwood, Liu, Marengère, Martin, Mayor, Monks, Muscolini, Muscolini, Muscolini, Nakamura, Owen, Paccani, Pagès, Pike, Pike, Pike, Pizzo, Porciello, Porciello, Pralle, Raab, Raab, Raychaudhuri, Resh, Roncagalli, Round, Ruppelt, Russell, Salazar-Fontana, Salomon, Sanchez-Lockhart, Schütz, Shahinian, Sherman, Simons, Simons, Subczynski, Tavano, Tavano, Varma, Varshney, Villalba, Villalba, Viola, Viola, Viola, Viola, von Haller, Watanabe, Yokosuka, Zhang, Zhang   +95 more
core   +1 more source

Ligand Mediated Sequestering of Integrins in Raft-Mimicking Lipid Mixtures: The Role of Bilayer Asymmetry and Cholesterol Content [PDF]

, 2013
poster abstractLipid microdomains play an important functional role in plasma membranes. However, the small size and transient nature of lipid/membrane heterogeneities in the plasma membrane make characterization of microdomains and microdomain-related
Gao, Jiayun, Hussain, Noor F., Jordan, Rainer, Naumann, Christoph A., Siegel, Amanda P.   +4 more
core