Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation [PDF]
Journal of Cell Biology, 2001 Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor–mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Robert T. Watson +7 more
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Detergent-resistant plasma membrane proteomes for elucidating microdomain functions in plant cells [PDF]
Frontiers in Plant Science, 2013 Although proteins and lipids have been assumed to be distributed homogeneously in the plasma membrane (PM), recent studies suggest that the PM is non-uniform, forming a structure that includes a number of lateral domains enriched in specific components ...
Daisuke eTakahashi +4 more
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Feeding-fasting dependent recruitment of membrane microdomain proteins to lipid droplets purified from the liver. [PDF]
PLoS ONE, 2017 Lipid droplets (LDs) are cellular stores of neutral fat that facilitate lipid and protein trafficking in response to metabolic cues. Unlike other vesicles, the phospholipid membrane on the LD is a monolayer.
Kritika Sadh, Priyanka Rai, Roop Mallik
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Molecular Biology of the Cell, 2021 Microlipophagy (µLP), degradation of lipid droplets (LDs) by microautophagy, occurs by autophagosome-independent direct uptake of LDs at lysosomes/vacuoles in response to nutrient limitations and ER stressors in Saccharomyces cerevisiae.
Pin-Chao Liao +4 more
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Lipid rafts: The enigmatic membrane microdomain [PDF]
The Biochemist, 2009 In the field of membrane biology, perhaps one of the most controversial concepts in recent years has been the enigmatic membrane microdomain, the cholesterol- and glycosphingolipid-rich lipid raft.
David R. Taylor, Nigel M. Hooper
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α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein [PDF]
Journal of Lipid Research, 2015 α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent. In vitro, its free radical-scavenging antioxidant action has been widely demonstrated.
Sterenn Davis +6 more
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Role of MCC/Eisosome in Fungal Lipid Homeostasis
Biomolecules, 2019 One of the best characterized fungal membrane microdomains is the MCC/eisosome. The MCC (membrane compartment of Can1) is an evolutionarily conserved ergosterol-rich plasma membrane domain.
Jakub Zahumensky, Jan Malinsky
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Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation [PDF]
Journal of Lipid ResearchPhospholipase D2 (PLD2) plays critical roles in cellular signaling, membrane dynamics, and cancer progression. Oleate (OA) has been shown to activate PLD2 and promote triple-negative breast cancer (TNBC) cell migration, but the underlying molecular ...
Zhiqiang Guo +2 more
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An Association Between Peptidoglycan Synthesis and Organization of the
mBio, 2013 The ExPortal of Streptococcus pyogenes is a focal microdomain of the cytoplasmic membrane that clusters the translocons of the general secretory pathway with accessory factors to facilitate the maturation of secreted polypeptides.
Luis Alberto Vega +2 more
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Update on lipid membrane microdomains
Current Opinion in Clinical Nutrition and Metabolic Care, 2008 Lipid membrane microdomains are involved in major types of disease, ranging from vascular and metabolic diseases to neurodegeneration, autoimmunity, infectious and inflammatory diseases, and cancer. This review provides an update of membrane microdomain abnormalities.Lipid membrane microdomains are dynamic assemblies of sphingolipids, cholesterol and ...
Gerd Schmitz, Margot Grandl
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