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Update on lipid membrane microdomains
Current Opinion in Clinical Nutrition and Metabolic Care, 2008Lipid membrane microdomains are involved in major types of disease, ranging from vascular and metabolic diseases to neurodegeneration, autoimmunity, infectious and inflammatory diseases, and cancer. This review provides an update of membrane microdomain abnormalities.Lipid membrane microdomains are dynamic assemblies of sphingolipids, cholesterol and ...
Gerd Schmitz, Margot Grandl
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Lipid Microdomains in Synapse Formation
ACS Chemical Neuroscience, 2016Membrane lipid rafts (i.e., cholesterol/sphingolipids domains) exhibit functional roles in both healthy and pathological states of the nervous system. However, due to their highly dynamic nature, it remains a challenge to characterize the fundamental aspects of lipid rafts that are important for specific neuronal processes.
R. Bruce Lennox +2 more
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Lipid microdomains in dimyristoylphosphatidylcholine–ceramide liposomes
Chemistry and Physics of Lipids, 1997Binary membranes composed of dimyristoylphosphatidylcholine (DMPC) and natural ceramide (up to a mole fraction Xcer = 0.25) were investigated by measuring the excimer:monomer fluorescence emission intensity ratio IE:IM for the pyrene labeled phospholipid probe 1-palmitoyl-2[(pyren-1-yl)]decanoyl-sn-glycero-3-phosphocholine (PPDPC), by monitoring ...
Jukka Y. A. Lehtonen +2 more
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Lipid Microdomains and Insulin Resistance: Is There a Connection?
Science's STKE, 2005The potential contribution of lipids to insulin signaling has excited interest because of the notion that cholesterol and sphingolipids form functional microdomains—lipid rafts—in cell membranes and that these domains may affect signal transduction. In this Perspective, we discuss the evidence suggesting that cholesterol-sphingolipid rafts play a role ...
Elina Ikonen, Saara Vainio
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Lipid raft microdomains and neurotransmitter signalling
Nature Reviews Neuroscience, 2006Lipid rafts are specialized structures on the plasma membrane that have an altered lipid composition as well as links to the cytoskeleton. It has been proposed that these structures are membrane domains in which neurotransmitter signalling might occur through a clustering of receptors and components of receptor-activated signalling cascades.
Robyn A. Halverson-Tamboli +2 more
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Microdomains Associated to Lipid Rafts
2016Store Operated Ca(2+) Entry (SOCE), the main Ca(2+) influx mechanism in non-excitable cells, is implicated in the immune response and has been reported to be affected in several pathologies including cancer. The basic molecular constituents of SOCE are Orai, the pore forming unit, and STIM, a multidomain protein with at least two principal functions ...
Jonathan Pacheco +2 more
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Sphingolipids in Lipid Microdomains and Obesity
2013Sphingolipids are major constituents of the plasma membrane, where they are known to form lipid microdomains with cholesterol. Lipid microdomains are thought to be important not only for cellular signal transduction but also for the absorption of extracellular lipids or nutrients.
Yasuyuki Igarashi, Susumu Mitsutake
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Lipid-Based Membrane Microdomains in T Cell Activation
Current Immunology Reviews, 2005The immune system is able to mount an immune response against antigens present in the body at very low concentrations and, at the same time, to discriminate precisely between an infectious stimulus and a non-infectious one. During T cell activation, this sensitivity and specificity are achieved by mechanisms of sustained interactions with antigen ...
PIZZO, PAOLA, VIOLA A.
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