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Lipid Microdomains in Synapse Formation
ACS Chemical Neuroscience, 2016Membrane lipid rafts (i.e., cholesterol/sphingolipids domains) exhibit functional roles in both healthy and pathological states of the nervous system. However, due to their highly dynamic nature, it remains a challenge to characterize the fundamental aspects of lipid rafts that are important for specific neuronal processes.
C, Madwar +2 more
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Lipid microdomains in dimyristoylphosphatidylcholine–ceramide liposomes
Chemistry and Physics of Lipids, 1997Binary membranes composed of dimyristoylphosphatidylcholine (DMPC) and natural ceramide (up to a mole fraction Xcer = 0.25) were investigated by measuring the excimer:monomer fluorescence emission intensity ratio IE:IM for the pyrene labeled phospholipid probe 1-palmitoyl-2[(pyren-1-yl)]decanoyl-sn-glycero-3-phosphocholine (PPDPC), by monitoring ...
J M, Holopainen +2 more
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Lipid raft microdomains and neurotransmitter signalling
Nature Reviews Neuroscience, 2006Lipid rafts are specialized structures on the plasma membrane that have an altered lipid composition as well as links to the cytoskeleton. It has been proposed that these structures are membrane domains in which neurotransmitter signalling might occur through a clustering of receptors and components of receptor-activated signalling cascades.
John A, Allen +2 more
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Lipid microdomains – plant membranes get organized
Trends in Plant Science, 2005The plant plasma membrane is now known to be a more sophisticated structure than was previously thought. Sebastien Mongrand et al. and Georg Borner et al. have isolated specific plasma membrane microdomains ('lipid rafts') that are enriched in sterols and sphingolipids.
Stephen W, Martin +2 more
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Microdomains Associated to Lipid Rafts
2016Store Operated Ca(2+) Entry (SOCE), the main Ca(2+) influx mechanism in non-excitable cells, is implicated in the immune response and has been reported to be affected in several pathologies including cancer. The basic molecular constituents of SOCE are Orai, the pore forming unit, and STIM, a multidomain protein with at least two principal functions ...
Jonathan, Pacheco +2 more
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Sphingolipids in Lipid Microdomains and Obesity
2013Sphingolipids are major constituents of the plasma membrane, where they are known to form lipid microdomains with cholesterol. Lipid microdomains are thought to be important not only for cellular signal transduction but also for the absorption of extracellular lipids or nutrients.
Susumu, Mitsutake, Yasuyuki, Igarashi
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