Results 291 to 300 of about 1,147,179 (336)
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Lipid Microdomains: Structural Correlations, Fluctuations, and Formation Mechanisms
Physical Review Letters, 2010Compositional lipid microdomains ("lipid rafts") in mammalian plasma membranes are believed to facilitate many important cellular processes. While several physically distinct scenarios predicting the presence of finite-sized microdomains in vivo have been proposed in the past, direct experimental verification or falsification of model predictions has ...
Jun, Fan +2 more
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PROTEOMICS, 2006
AbstractBiological membranes are compartmentalized into microdomains that exhibit particular lipid and protein compositions. Membrane microdomains, such as tetraspanin‐enriched microdomains and lipid rafts, have been suggested to play a role in a variety of physiological and pathological processes.
François, Le Naour +3 more
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AbstractBiological membranes are compartmentalized into microdomains that exhibit particular lipid and protein compositions. Membrane microdomains, such as tetraspanin‐enriched microdomains and lipid rafts, have been suggested to play a role in a variety of physiological and pathological processes.
François, Le Naour +3 more
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2021
Recently, we reported that a ternary lipid bilayer comprising phosphatidylethanolamine (PE), phosphatidylcholine (PC), which were both derived from chicken egg, and cholesterol (Chol) generates microdomains that function as specific fusion sites for proteoliposomes.
Melvin Wei Shern, Goh, Ryugo, Tero
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Recently, we reported that a ternary lipid bilayer comprising phosphatidylethanolamine (PE), phosphatidylcholine (PC), which were both derived from chicken egg, and cholesterol (Chol) generates microdomains that function as specific fusion sites for proteoliposomes.
Melvin Wei Shern, Goh, Ryugo, Tero
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Lipid-Based Membrane Microdomains in T Cell Activation
Current Immunology Reviews, 2005The immune system is able to mount an immune response against antigens present in the body at very low concentrations and, at the same time, to discriminate precisely between an infectious stimulus and a non-infectious one. During T cell activation, this sensitivity and specificity are achieved by mechanisms of sustained interactions with antigen ...
PIZZO, PAOLA, VIOLA A.
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Phase Separation of Lipid Microdomains Controlled by Polymerized Lipid Bilayer Matrices
Langmuir, 2009We developed a micropatterned model biological membrane on a solid substrate that can induce phase separation of lipid microdomains in a designed geometry. Micropatterned lipid bilayers were generated by the photolithographic polymerization of a diacetylene phospholipid, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DiynePC).
Takashi, Okazaki +2 more
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The Role of Lipid Microdomains in Virus Biology
2004Many of the highly pathogenic viruses including influenza virus, HIV and others of world wide epidemiological importance are enveloped and possess a membrane around the nucleocapsid containing the viral genome. Viral membrane is required to protect the viral genome and provide important functions for attachment, morphogenesis and transmission.
Debi P, Nayak, Eric K W, Hui
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Accelerated Enzymatic Galactosylation of N-Acetylglucosaminolipids in Lipid Microdomains
Journal of the American Chemical Society, 2012A fluoro-tagged N-acetylglucosamine-capped glycolipid that can form lipid microdomains in fluid phospholipid bilayers has been shown to be enzymatically galactosylated by bovine β(1,4)-galactosyltransferase. MALDI MS, HPLC, and LC-MS revealed that the rate of enzymatic transformation was significantly enhanced by lipid clustering; at a 1% mol/mol ...
Noble, Gavin T. +5 more
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Molecular Membrane Biology, 2003
Eukaryotic cells contain hundreds of different lipid species that are not uniformly distributed among their membranes. For example, sphingolipids and sterols form gradients along the secretory pathway with the highest levels in the plasma membrane and the lowest in the endoplasmic reticulum.
Joost C M, Holthuis +2 more
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Eukaryotic cells contain hundreds of different lipid species that are not uniformly distributed among their membranes. For example, sphingolipids and sterols form gradients along the secretory pathway with the highest levels in the plasma membrane and the lowest in the endoplasmic reticulum.
Joost C M, Holthuis +2 more
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Lipid Microdomains and Insulin Resistance: Is There a Connection?
Science's STKE, 2005The potential contribution of lipids to insulin signaling has excited interest because of the notion that cholesterol and sphingolipids form functional microdomains—lipid rafts—in cell membranes and that these domains may affect signal transduction. In this Perspective, we discuss the evidence suggesting that cholesterol-sphingolipid rafts play a role ...
Elina, Ikonen, Saara, Vainio
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Lipid microdomains and membrane trafficking in mammalian cells
Histochemistry and Cell Biology, 1997This overview summarizes the data for how epithelial cells sort and deliver proteins and lipids to the apical and basolateral cell surface domains. The basolateral pathway uses a Rab-SNARE mechanism for docking and fusion, while the apical route employs a different machinery. This latter mechanism is based on lipid microdomains, composed of clusters of
Paul Verkade, K. Simons
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