European Journal of Cell Biology, 2021 Membrane microdomains or rafts, sterol- and sphingolipid-rich microdomains in the plasma membrane have been studied extensively in mammalian cells. Recently, rafts were found to mediate virulence in a variety of parasites, including Toxoplasma gondii ...
Rikako Konishi +5 more
doaj +1 more source
Involvement of lipid microdomains in human endothelial cells infected by Streptococcus agalactiae type III belonging to the hypervirulent ST-17 [PDF]
Memorias do Instituto Oswaldo CruzBACKGROUND Streptococcus agalactiae capsular type III strains are a leading cause of invasive neonatal infections. Many pathogens have developed mechanisms to escape from host defense response using the host membrane microdomain machinery.
Beatriz Jandre Ferreira +5 more
doaj +2 more sources
The differential protein and lipid compositions of noncaveolar lipid microdomains and caveolae [PDF]
Cell Research, 2009 Morphologically, caveolae and lipid rafts are two different membrane structures. They are often reported to share similar lipid and protein compositions, and are considered to be two subtypes of membrane lipid microdomains. By modifying sucrose density gradient flotation centrifugation, which is used to isolate lipid microdomains, we were able to ...
Yao Yao +5 more
openaire +3 more sources
Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains [PDF]
Biophysical Journal, 2021 AbstractSphingolipids are a structurally diverse class of lipids predominantly found in the plasma membrane of eukaryotic cells. These lipids can laterally segregate with other saturated lipids and cholesterol into lipid rafts; liquid-ordered (Lo) microdomains that act as organizing centers within biomembranes. Owing the vital role of sphingolipids for
Hartrampf, Nina +7 more
openaire +3 more sources
Lipid rafts: The enigmatic membrane microdomain [PDF]
The Biochemist, 2009 In the field of membrane biology, perhaps one of the most controversial concepts in recent years has been the enigmatic membrane microdomain, the cholesterol- and glycosphingolipid-rich lipid raft.
Nigel M. Hooper, David R. Taylor
openaire +1 more source
The membrane-associated form of α(s1)-casein interacts with cholesterol-rich detergent-resistant microdomains. [PDF]
PLoS ONE, 2014 Caseins, the main milk proteins, interact with colloidal calcium phosphate to form the casein micelle. The mesostructure of this supramolecular assembly markedly influences its nutritional and technological functionalities.
Annabelle Le Parc +5 more
doaj +1 more source
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
core +1 more source
Journal of Lipid Research, 2005 GM1a [Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ1-1Cer] is known to support and protect neuronal functions. However, we report that α-linolenic acid-containing GM1a (C18:3-GM1a), which was prepared using the reverse hydrolysis reaction of sphingolipid ...
Tetsuto Nakagawa +5 more
doaj +1 more source
Cholesterol and lipid microdomains stabilize the postsynapse at the neuromuscular junction [PDF]
The EMBO Journal, 2006 Stabilization and maturation of synapses are important for development and function of the nervous system. Previous studies have implicated cholesterol-rich lipid microdomains in synapse stabilization, but the underlying mechanisms remain unclear. We found that cholesterol stabilizes clusters of synaptic acetylcholine receptors (AChRs) in denervated ...
Willmann, R +6 more
openaire +4 more sources
The Effects of Cholesterol Oxidation on Erythrocyte Plasma Membranes: A Monolayer Study
Membranes, 2022 Cholesterol plays a key role in the molecular and mesoscopic organisation of lipid membranes and it is expected that changes in its molecular structure (e.g., through environmental factors such as oxidative stress) may affect adversely membrane ...
Bob-Dan Lechner +9 more
doaj +1 more source