Results 61 to 70 of about 1,061,660 (313)

Lipid Raft Microdomains [PDF]

The Journal of Experimental Medicine, 2002
Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as functional platforms for multiple cellular signaling and trafficking processes. Here, we report the compartmentalization of Ebola and Marburg viral proteins within lipid rafts during viral assembly and budding.
Bavair, Sina, Bosio, Catherine, Wiegand, Elizabeth, Ruthel, Gordon, Will, Amy, Geisbert, Thomas, Hevey, Michael, Schmaljohn, Connie, U.S. Army Medical Research Institute of Infectious Diseases, Aman, M. Javad   +9 more
openaire   +3 more sources

Variational Methods for Biomolecular Modeling

, 2016
Structure, function and dynamics of many biomolecular systems can be characterized by the energetic variational principle and the corresponding systems of partial differential equations (PDEs).
A Ivankin, A Jaramillo, A Warshel, AB Camley, B Lee, B Li, B Li, B Li, B Lu, B Lu, B Wang, BJ Reynwar, BR Brooks, C Mim, D Marsh, D Spoel Van Der, DG Thomas, DL Parton, E Gallicchio, E Gallicchio, EA Evans, F Campelo, FH Stillinger, FM Richards, FS Cohen, G Archontis, G-W Wei, G-W Wei, G-W Wei, GP Leser, GW Wei, HT McMahon, HY Lin, I Massova, I Park, IR Cooke, J Dzubiella, J Faraudo, J Gumbart, J Strain, J Wagoner, J Zimmerberg, JA Grant, JA Grant, JA Grant, JA Wagoner, JC Phillips, JC Stachowiak, JD Madura, JE Rothman, JMJ Swanson, K Farsad, K Lum, K Simons, KA Sharp, KM Callenberg, KS Kim, L-T Gao, LJ Pike, M Daily, M Feig, MD Huang, ME Davis, N Choudhury, N Gavish, NA Baker, NW Schmidt, O Sten-Knudsen, P Concus, P Grochowski, PB Canham, PW Bates, PW Bates, Q Du, Q Du, Q Du, Q Zheng, Q Zheng, R Brewster, R Brewster, R Parthasarathy, RA Pierotti, RE Skyner, RJ Ryham, S Choe, S Dai, S Li, S Osher, S Xu, S Zhao, S Zhao, SC Brenner, T Baumgart, T Kirchhausen, T Simonson, T Sollner, T Takahashi, T Witkowski, T-L Horng, V Luzhkov, VB Chu, W Geng, X Chen, X Chen, Y Tang, Y Wang, Y Wang, Y Wang, Y Zhao, YC Zhou, YC Zhou, Z Chen, Z Chen, Z Chen, ZY Yu   +114 more
core   +1 more source

Membrane fluidity matters: Hyperthermia from the aspects of lipids and membranes [PDF]

, 2013
Hyperthermia is a promising treatment modality for cancer in combination both with radio- and chemotherapy. In spite of its great therapeutic potential, the underlying molecular mechanisms still remain to be clarified.
Ahyayauch H, Anderson RL, Angelucci C, Balboa MA, Balint Csoboz, Balogh G, Balogh G, Balogi Z, Balogi Z, Balsinde J, Batko J, Benkö S, Brameshuber M, Burcin Gungor, Cadenas C, Calderwood SK, Calderwood SK, Carracedo A, Chau LY, Chung J, Corda D, Crul T, Erzsebet Kusz, Escribá P V, Funaki N, Gabai VL, Gabor E. Balogh, Giocondi M-C, Gombos I, Gordana Bogdanovics, Grassme H, Griner EM, Heilbrunn LV, Hirabayashi T, Horváth I, Horváth I, Horváth I, Horváth I, Hønger T, Hønger T, Ibolya Horvath, Imre Gombos, Juhász K, Jurivich DA, Kiang JG, Kirkegaard T, Klose C, Koklic T, Lajos Haracska, Laszlo Vigh, Mace TA, Maria Peter, Menendez JA, Miller RC, Mukherjee S, Nagy E, Nakamoto H, Nomura DK, Noonan EJ, Olivera-Couto A, Ostberg JR, Pallepati P, Patra SK, Peer AJ, Péter M, Redman CA, Samples BL, Segui B, Sherbet G V, Shigapova N, Shimizu T, Simons K, Sok M, Takahashi A, Tang X, Taraboletti G, Tim Crul, Tsvetkova NM, Török Z, Török Z, Török Z, Vigh L, Vigh L, Vigh L, Vigh L, Vigh L, Vigh L, Vigh L, Wakelam MJ, Wymann MP, Yatvin MB, Yukihara M, Zeisig R, Zhang F, Zsolt Torok   +94 more
core   +1 more source

A novel soluble analog of the HIV-1 fusion cofactor, globotriaosylceramide (Gb3), eliminates the cholesterol requirement for high affinity gp120/Gb3 interaction

Journal of Lipid Research, 2002
We have analyzed the interaction of adamantyl Gb3 (adaGb3), a semi-synthetic soluble analog of Gb3, with HIV-1 surface envelope glycoprotein gp120. In this analog, which was orginally designed to inhibit verotoxin binding to its glycolipid receptor, Gb3,
Radhia Mahfoud, Murugesapillai Mylvaganam, Clifford A. Lingwood, Jacques Fantini   +3 more
doaj   +1 more source

The trafficking and targeting of P2X receptors [PDF]

, 2013
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D, Robinson, Lucy E   +1 more
core   +3 more sources

Thematic Review Series: Sphingolipids. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease—a review*1

Journal of Lipid Research, 2008
Gangliosides are expressed in the outer leaflet of the plasma membrane of the cells of all vertebrates and are particularly abundant in the nervous system. Ganglioside metabolism is closely associated with the pathology of Alzheimer's disease (AD).
Toshio Ariga, Michael P. McDonald, Robert K. Yu   +2 more
doaj   +1 more source

The Molecular Switching Mechanism at the Conserved D(E)RY Motif in Class-A GPCRs [PDF]

, 2016
The disruption of ionic and H-bond interactions between the cytosolic ends of transmembrane helices TM3 and TM6 of class-A (rhodopsin-like) G protein-coupled receptors (GPCRs) is a hallmark for their activation by chemical or physical stimuli.
Abusharkh, Alexov, Angelica Sandoval, Arnis, Ballesteros, Borisovska, Castile, Choe, Cohen, Dickson, Dizhoor, Dror, Fahmy, Fahmy, Farrens, Georgescu, Gleason, Herrmann, Hess, Hofmann, Hoover, Hornak, Jorgensen, Jäger, Jämbeck, Karim Fahmy, Khesbak, Kim, Knierim, Krishnakumar, Lagerström, Lew, Lüdeke, Madathil, Mahalingam, Maier, Miyamoto, Nosé, Nygaard, Opefi, Palczewski, Palczewski, Park, Parrinello, Philip J. Reeves, Pronk, Rainer A. Böckmann, Rockland, Scheerer, Shahidullah, Sheikh, Shi, Sineej Madathil, Song, Standfuss, Standfuss, Stefanie Eichler, Vivian, Vogel, Vogel, Wolf, Yan   +61 more
core   +1 more source

Chitin perception in plasmodesmata characterizes submembrane immune-signaling specificity in plants [PDF]

, 2020
The plasma membrane (PM) is composed of heterogeneous subdomains, characterized by differences in protein and lipid composition. PM receptors can be dynamically sorted into membrane domains to underpin signaling in response to extracellular stimuli.
Bellandi, Annalisa, Breakspear, Andrew, Cheval, Cécilia, de Keijzer, Jeroen, Faulkner, Christine, Johnston, Matthew G., Kadota, Yasuhiro, Liu, Xiaokun, Samwald, Sebastian, Zipfel, Cyril   +9 more
core   +2 more sources

Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance. [PDF]

PLoS ONE, 2012
Prolonged usage of antifungal azoles which target enzymes involved in lipid biosynthesis invariably leads to the development of multi-drug resistance (MDR) in Candida albicans.
Ashutosh Singh, Vipin Yadav, Rajendra Prasad   +2 more
doaj   +1 more source

α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis

Frontiers in Cell and Developmental Biology, 2021
BackgroundNicotine exerts direct effects on multiple cell types in the cardiovascular system by associating with its high-affinity nicotinic acetylcholine receptors (nAchRs).
Fengqi Duan, Cheng Zeng, Sijun Liu, Jianfeng Gong, Jia Hu, Hongyu Li, Hongmei Tan, Hongmei Tan, Hongmei Tan   +8 more
doaj   +1 more source