Results 251 to 260 of about 133,206 (305)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Exploring the potential of saponins as adjuvants in lipid-nanoparticle-based mRNA vaccines. [PDF]

Mol Ther Methods Clin Dev
Eygeris Y, Jozic A, Henderson MI, Nelson D, Sahay G.   +4 more
europepmc   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol. [PDF]

Nat Commun
Johansson JM, Du Rietz H, Hedlund H, Eriksson HC, Oude Blenke E, Pote A, Harun S, Nordenfelt P, Lindfors L, Wittrup A.   +9 more
europepmc   +1 more source

Nanocoding: Lipid Nanoparticle Barcoding for Multiplexed Single-Cell RNA Sequencing. [PDF]

ACS Nano
Feng Y, Chen D, Applegate C, Gonzalez Medina N, Kuo CW, Arogundade OH, Wright CL, Xu F, Drnevich J, Smith AM.   +9 more
europepmc   +1 more source

An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy. [PDF]

Nat Commun
Zhu Y, Yao ZC, Li S, Ma J, Wei C, Yu D, Stelzel JL, Ni BYX, Miao Y, Van Batavia K, Lu X, Lin J, Dai Y, Kong J, Shen R, Goodier KD, Liu X, Cheng L, Vuong I, Howard GP, Livingston NK, Choy J, Schneck JP, Doloff JC, Reddy SK, Hickey JW, Mao HQ.   +26 more
europepmc   +1 more source

Exploring the Challenges of Lipid Nanoparticle Development: The In Vitro-In Vivo Correlation Gap. [PDF]

Vaccines (Basel)
Lindsay S, Hussain M, Binici B, Perrie Y.   +3 more
europepmc   +1 more source

A glycoprotein D-targeted lipid nanoparticle-encapsulated mRNA vaccine elicits strong protective immunity against pseudorabies virus. [PDF]

J Virol
Sun Y, Xu S-J, Zhou Y, Zhang Y, Zhang H, Le T, Bai Y-Z, Rao C-H, Huo S, Zhou T, An T-Q, Yin X, Yu F, Cai X-H, Tang Y-D.   +14 more
europepmc   +1 more source

Lipid nanoparticles for mRNA delivery [PDF]

Nature Reviews Materials, 2021
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release.
Xucheng Hou, Robert Samuel Langer Jr, Yi-Zhou Dong   +2 more
exaly   +3 more sources

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Carbohydrate anchored lipid nanoparticles

International Journal of Pharmaceutics, 2022
Nanotechnology has been a dynamic field for formulation scientists with multidisciplinary research being conducted worldwide. Advancements in development of functional nanosystems have led to evolution of breakthrough technologies. Lipidic nanosystems, in particular, are highly preferred owing to their non-immunogenic safety profiles along with a range
Pratik, Kakade, Arkasubhro, Chatterjee, Anjali, Pandya, John, Disouza, Vandana, Patravale   +4 more
openaire   +2 more sources