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Solid Lipid Nanoparticles

2020
Recent advances in the development of nanocarriers have started a new era in Formulation Science. Among various nanoparticles, solid lipid nanoparticles (SLNs) offer an attractive carrier system to conventional colloidal carriers, such as emulsions, microemulsions, self micro-emulsifying drug delivery system, micellar systems, liposomes, polymeric ...
Akhlesh Kumar Jain, Suresh Thareja
openaire   +2 more sources

New Methods for Lipid Nanoparticles Preparation

Recent Patents on Drug Delivery & Formulation, 2011
Lipid nanoparticles have attracted many researchers during recent years due to the excellent tolerability and advantages compared to liposomes and polymeric nanoparticles. High pressure homogenization is the main technique used to prepare solid lipid nanoparticles (SLN) encapsulating different type of drugs, however this method involves some critical ...
CORRIAS, FRANCESCO, LAI, FRANCESCO
openaire   +2 more sources

Lipid Nanoparticles for Drug Targeting to the Brain

2012
In this chapter, the main production methods of lipid nanostructures such as solid lipid nanoparticles and nanostructured lipid carriers, and their application are described. In particular, we describe the strategies commonly used to obtain lipid nanoparticles to overcome the blood-brain barrier (BBB) for the treatment of several brain diseases.
Bondì, ML   +2 more
openaire   +4 more sources

Interactions of Lipidic Cubic Phase Nanoparticles with Lipid Membranes

Langmuir, 2016
The interactions of liquid-crystalline monoolein (GMO) cubic phase nanoparticles with various model lipid membranes spread at the air-solution interface by the Langmuir technique were investigated. Cubosomes have attracted attention as potential biocompatible drug delivery systems, and thus understanding their mode of interaction with membranes is of ...
Jabłonowska, Elżbieta   +6 more
openaire   +3 more sources

Nanoparticles and Their Applications in Lipid Signaling

This chapter provides an overview of the diverse range of applications associated with nanoparticles. The application of nanoparticles in the medical field has garnered considerable attention due to their unique properties and versatile compositions. They have shown promise in the treatment of cancer, fungal and viral infections, and pain management ...
Zeinab Fotouhi, Ashin   +7 more
openaire   +2 more sources

On the role of helper lipids in lipid nanoparticle formulations of siRNA

Nanoscale, 2019
In empty LNP formulations, DSPC–cholesterol resides in outer layers, whereas in loaded systems some of the DSPC–cholesterol is internalized together with siRNA.
Jayesh A. Kulkarni   +4 more
openaire   +2 more sources

Lipid Nanoparticles for the Delivery of mRNA

The development of lipid-based nanoparticles (LNPs) has significantly advanced the field of drug delivery, particularly for nucleic acids, such as mRNA being clinically used in the vaccines against COVID-19. This chapter explores the structural composition and functional properties of LNPs, including key components, such as ionizable cationic lipids ...
Sandra, Paroor   +9 more
openaire   +2 more sources

Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy

Advanced Materials, 2023
Yan Zong, Yi Lin, Tuo Wei
exaly  

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

International Journal of Pharmaceutics, 2021
Linde Schoenmaker   +2 more
exaly  

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

International Journal of Molecular Sciences, 2021
Bo Kyeong Yoon   +2 more
exaly  

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