Results 251 to 260 of about 2,353,041 (346)

Lipid Nanoparticle Fas Gene Therapy Suppresses Autoimmune Lymphoproliferative Syndrome in Mice. [PDF]

Blood Immunol Cell Ther
Poschel DB, Tiamiyu Z, Redd P, Merting A, Savage N, Liu K.   +5 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

A binary self-amplifying expression platform enabling lipid nanoparticle-free vaccines and nanomedicines. [PDF]

Nat Commun
Jefferies WA, Choi KB, Ribeca P, Kari S, Young JA, Hui E, Qi SY, Garrovillas E, Fan J, Cho BMY, Housh P, Welch T, Saranchova I, Pfeifer CG.   +13 more
europepmc   +1 more source

β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery

Advanced Science, EarlyView.
This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li, Haocheng Tang, Yiqing Mu, Shangyu Chen, Paul Edward Floreancig, Junmei Wang, Yixian Huang, Song Li   +7 more
wiley   +1 more source

Unique Aerofoil-Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale-up. [PDF]

Adv Sci (Weinh)
Liu D, Yu M, Zhang Y, Mathew A, Guan T, Yao L, Wang X, Wang W, Zhang N.   +8 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles. [PDF]

ACS Nano
Bhalotia A, Hutchinson DW, Kosmides T, Nittayacharn P, Mehta M, Iyer A, Cheplyansky A, Takizawa KH, Nidhiry A, Dever AM, Cousens KA, Hwang IM, Ramamurthy G, Exner AA, Karathanasis E.   +14 more
europepmc   +1 more source