Results 261 to 270 of about 88,630 (306)

Carbohydrate anchored lipid nanoparticles

International Journal of Pharmaceutics, 2022
Nanotechnology has been a dynamic field for formulation scientists with multidisciplinary research being conducted worldwide. Advancements in development of functional nanosystems have led to evolution of breakthrough technologies. Lipidic nanosystems, in particular, are highly preferred owing to their non-immunogenic safety profiles along with a range
Pratik, Kakade, Arkasubhro, Chatterjee, Anjali, Pandya, John, Disouza, Vandana, Patravale   +4 more
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Controlled Nucleation of Lipid Nanoparticles

Pharmaceutical Research, 2012
We describe a nucleation-based method which allows for the generation of monodisperse lipid nanoparticles over a range of diameters. Using a set of novel zwitterionic lipids and inverse phosphocholine lipids with pKas ranging from 2 to 5, we showed how the hydrodynamic diameter of lipid nanoparticles can be systematically manipulated over a 60 nm to ...
Juliane, Nguyen, Colin L, Walsh, J P Michael, Motion, Emily K, Perttu, Francis, Szoka   +4 more
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Stability of Lipid Excipients in Solid Lipid Nanoparticles

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Interaction of Nanoparticles with Lipid Membrane

Nano Letters, 2008
A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the l-alpha-dimyristoyl phosphatidylcholine membrane around 1.2-22 nm polar nanoparticles deposited on mica surface.
Yuri, Roiter, Maryna, Ornatska, Aravind R, Rammohan, Jitendra, Balakrishnan, David R, Heine, Sergiy, Minko   +5 more
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Blood Distribution of SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine in Humans

ACS Nano
Lipid nanoparticle mRNA vaccines are an exciting but emerging technology used in humans. There is limited understanding of the factors that influence their biodistribution and immunogenicity.
Stephen J Kent, Wen Shi Lee, Helen E Kent   +2 more
exaly   +4 more sources

Lipid Nanoparticles and their Application in Nanomedicine

Current Pharmaceutical Biotechnology, 2016
In recent years many different nanotechnology platforms have been developed for both diagnostics and cancer therapy. Researchers have been attracted to use lipid-based nanoparticles with particle size approximately 100 nm as a new pharmaceutical delivery system or pharmaceutical formulation that can be assembled from different types of lipid or other ...
Mehdi, Rajabi, Shaker A, Mousa
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Interaction of nanoparticles with lipid layers

Physical Review E, 2009
Poly (amidoamine) dendrimer nanoparticles are used extensively in diverse biological and medical applications. Examples include gene and drug delivery, where nanoparticles disrupt cell membranes to allow the transport of material into cells. The size and surface chemistry of these particles have a strong effect on their interaction with membranes. This
Jonghyun, Park, Wei, Lu
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Lipid nanoparticles

2021
The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid.
Bevers, Sanne, De Koker, Stefaan, Schiffelers, Michel Raymond, KOOIJMANS, SANDER ALEXANDER ANTONIUS   +3 more
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Lipid nanoparticles

2023
The present invention relates to the field of lipid nanoparticles (LPN); more specifically comprising an ionisable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in having a minimal average diameter of about 140 nm, thereby inducing a more potent immune response.
De Koker, Stefaan, Bevers, Sanne, Tomme, Peter   +2 more
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Analysis of Lipid Nanoparticles

LCGC North America, 2023
Over the last several years, our definition of biotherapeutics has evolved from solely protein-based therapeutics, such as monoclonal antibodies (mAbs), to include such product classes as cell and gene therapies. Cell and gene therapies are unique products that require innovative and new approaches to formulation, specifically related to drug delivery.
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